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C0RW22

- CDK14_DASNO

UniProt

C0RW22 - CDK14_DASNO

Protein

Cyclin-dependent kinase 14

Gene

CDK14

Organism
Dasypus novemcinctus (Nine-banded armadillo)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei163 – 1631ATPPROSITE-ProRule annotation
    Active sitei255 – 2551Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi140 – 1489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G2/M transition of mitotic cell cycle Source: UniProtKB
    3. regulation of canonical Wnt signaling pathway Source: UniProtKB
    4. regulation of cell cycle Source: GOC
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 14 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 14
    Gene namesi
    Name:CDK14
    Synonyms:PFTK1
    OrganismiDasypus novemcinctus (Nine-banded armadillo)
    Taxonomic identifieri9361 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaXenarthraCingulataDasypodidaeDasypus

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity
    Note: Recruited to the cell membrane by CCNY.By similarity

    GO - Cellular componenti

    1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
    2. cytosol Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Cyclin-dependent kinase 14PRO_0000391900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiC0RW22.

    Interactioni

    Subunit structurei

    Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9361.ENSDNOP00000004393.

    Structurei

    3D structure databases

    ProteinModelPortaliC0RW22.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 418285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0RW22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKEDTTFD EICVTKMSTR    50
    NCQGMDSVIK PLDTIPEDKV RVQRTQSTFD PFEKPTNQVK RVHSENNACI 100
    NFKTSSAGKE SPKVRRHSSP SSPTSPKFGK ADSYEKLEKL GEGSYATVYK 150
    GKSKVNGKLV ALKVIRLQEE EGTPFTAIRE ASLLKGLKHA NIVLLHDIIH 200
    TKETLTLVFE YVHTDLCQYM DKHPGGLHPE NVKLFLFQLL RGLSYIHQRY 250
    ILHRDLKPQN LLISDTGELK LADFGLARAK SVPSHTYSNE VVTLWYRPPD 300
    VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ LERIFLVLGT 350
    PNEDTWPGVH SLPHFKPERF TLYSSKNLRQ AWNKLSYVNH AEDLASKLLQ 400
    CSPKNRLSAQ AALSHEYFSD LPPRLWELTD MSSIFTVPNV RLQPEAGESM 450
    RAFGKNNSYG KSLSNSKH 468
    Length:468
    Mass (Da):52,957
    Last modified:May 5, 2009 - v1
    Checksum:iE318D639D3E9F80C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP001073 Genomic DNA. Translation: ACN22218.1.

    Genome annotation databases

    EnsembliENSDNOT00000049657; ENSDNOP00000028603; ENSDNOG00000036809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP001073 Genomic DNA. Translation: ACN22218.1 .

    3D structure databases

    ProteinModelPortali C0RW22.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9361.ENSDNOP00000004393.

    Proteomic databases

    PRIDEi C0RW22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDNOT00000049657 ; ENSDNOP00000028603 ; ENSDNOG00000036809 .

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCDK14_DASNO
    AccessioniPrimary (citable) accession number: C0RW22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3