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C0RW22

- CDK14_DASNO

UniProt

C0RW22 - CDK14_DASNO

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Protein

Cyclin-dependent kinase 14

Gene

CDK14

Organism
Dasypus novemcinctus (Nine-banded armadillo)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei163 – 1631ATPPROSITE-ProRule annotation
Active sitei255 – 2551Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi140 – 1489ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. regulation of canonical Wnt signaling pathway Source: UniProtKB
  4. regulation of cell cycle Source: GOC
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:CDK14
Synonyms:PFTK1
OrganismiDasypus novemcinctus (Nine-banded armadillo)
Taxonomic identifieri9361 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaXenarthraCingulataDasypodidaeDasypus

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity
Note: Recruited to the cell membrane by CCNY.By similarity

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. cytosol Source: Ensembl
  3. nucleus Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Cyclin-dependent kinase 14PRO_0000391900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiC0RW22.

Interactioni

Subunit structurei

Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ (By similarity).By similarity

Protein-protein interaction databases

STRINGi9361.ENSDNOP00000004393.

Structurei

3D structure databases

ProteinModelPortaliC0RW22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 418285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0RW22-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKEDTTFD EICVTKMSTR
60 70 80 90 100
NCQGMDSVIK PLDTIPEDKV RVQRTQSTFD PFEKPTNQVK RVHSENNACI
110 120 130 140 150
NFKTSSAGKE SPKVRRHSSP SSPTSPKFGK ADSYEKLEKL GEGSYATVYK
160 170 180 190 200
GKSKVNGKLV ALKVIRLQEE EGTPFTAIRE ASLLKGLKHA NIVLLHDIIH
210 220 230 240 250
TKETLTLVFE YVHTDLCQYM DKHPGGLHPE NVKLFLFQLL RGLSYIHQRY
260 270 280 290 300
ILHRDLKPQN LLISDTGELK LADFGLARAK SVPSHTYSNE VVTLWYRPPD
310 320 330 340 350
VLLGSTEYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ LERIFLVLGT
360 370 380 390 400
PNEDTWPGVH SLPHFKPERF TLYSSKNLRQ AWNKLSYVNH AEDLASKLLQ
410 420 430 440 450
CSPKNRLSAQ AALSHEYFSD LPPRLWELTD MSSIFTVPNV RLQPEAGESM
460
RAFGKNNSYG KSLSNSKH
Length:468
Mass (Da):52,957
Last modified:May 5, 2009 - v1
Checksum:iE318D639D3E9F80C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP001073 Genomic DNA. Translation: ACN22218.1.

Genome annotation databases

EnsembliENSDNOT00000049657; ENSDNOP00000028603; ENSDNOG00000036809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP001073 Genomic DNA. Translation: ACN22218.1 .

3D structure databases

ProteinModelPortali C0RW22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9361.ENSDNOP00000004393.

Proteomic databases

PRIDEi C0RW22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDNOT00000049657 ; ENSDNOP00000028603 ; ENSDNOG00000036809 .

Phylogenomic databases

eggNOGi COG0515.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCDK14_DASNO
AccessioniPrimary (citable) accession number: C0RW22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3