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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciBMEL546272:G1GV6-3240-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:BMEA_B1056
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000001748 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001845591 – 218Peptide methionine sulfoxide reductase MsrAAdd BLAST218

Proteomic databases

PRIDEiC0RMK6

Structurei

3D structure databases

SMRiC0RMK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263862
KOiK07304
OMAiMRQGGDI

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

C0RMK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ
60 70 80 90 100
VLFGMGCFWG AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE
110 120 130 140 150
VVLVVYDPKV VTLNELLALF WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV
160 170 180 190 200
DRAVAEKSRD AYSQALASRG LGPVTTQITE APDFYYAEDY HQQYLAKNPD
210
GYCGLRGTGV SCPIPLAH
Length:218
Mass (Da):24,061
Last modified:May 5, 2009 - v1
Checksum:i81A1201066741606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001489 Genomic DNA Translation: ACO02839.1
RefSeqiWP_004685934.1, NC_012442.1

Genome annotation databases

EnsemblBacteriaiACO02839; ACO02839; BMEA_B1056
KEGGibmi:BMEA_B1056

Similar proteinsi

Entry informationi

Entry nameiMSRA_BRUMB
AccessioniPrimary (citable) accession number: C0RMK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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