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C0RMI1

- UPPP_BRUMB

UniProt

C0RMI1 - UPPP_BRUMB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBMEL546272:GJOX-3185-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:BMEA_B1027
    OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
    Taxonomic identifieri546272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000001748: Chromosome II

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Undecaprenyl-diphosphatasePRO_1000148803Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi546272.BMEA_B1027.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalUniRule annotationAdd
    BLAST
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei84 – 10421HelicalUniRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalUniRule annotationAdd
    BLAST
    Transmembranei144 – 16421HelicalUniRule annotationAdd
    BLAST
    Transmembranei185 – 20521HelicalUniRule annotationAdd
    BLAST
    Transmembranei213 – 23321HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiVIYFRNE.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0RMI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFFNLLEAA FLGLIEGLTE FIPVSSTGHL LLIGHFLGFE STGKTFEVLI    50
    QLGAILAILS VYSAKLARIA TDFPRDARTR RFVLGVLVAF LPAAVIGALA 100
    HGFIKGVLFE TPMLVCIMLI VGGFILLWVD QLNLRPRYHN VMDYPLPICL 150
    AIGFIQCLAM IPGVSRSGST IVGSLLLGAD KRSAAEFSFF LAMPTMAGAF 200
    AYDLFKSRNI LSFNDGALIV VGFIMAFISG VFVVRHLLDY VSRHGFALFG 250
    WWRLIVGSAG MAALIIWG 268
    Length:268
    Mass (Da):29,169
    Last modified:May 5, 2009 - v1
    Checksum:i10A3AFD1330B2CAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001489 Genomic DNA. Translation: ACO02814.1.
    RefSeqiYP_002734768.1. NC_012442.1.

    Genome annotation databases

    EnsemblBacteriaiACO02814; ACO02814; BMEA_B1027.
    GeneIDi7671523.
    KEGGibmi:BMEA_B1027.
    PATRICi17842442. VBIBruMel14466_3315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001489 Genomic DNA. Translation: ACO02814.1 .
    RefSeqi YP_002734768.1. NC_012442.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 546272.BMEA_B1027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO02814 ; ACO02814 ; BMEA_B1027 .
    GeneIDi 7671523.
    KEGGi bmi:BMEA_B1027.
    PATRICi 17842442. VBIBruMel14466_3315.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi VIYFRNE.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BMEL546272:GJOX-3185-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
      Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
      , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23457.

    Entry informationi

    Entry nameiUPPP_BRUMB
    AccessioniPrimary (citable) accession number: C0RMI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3