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C0RMG8 (DAPD_BRUMB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:BMEA_B1014
OrganismBrucella melitensis biotype 2 (strain ATCC 23457) [Complete proteome] [HAMAP]
Taxonomic identifier546272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_1000148582

Sites

Binding site1111Substrate By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
C0RMG8 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 48231A894992DA4B

FASTA28430,726
        10         20         30         40         50         60 
MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA EKQADGNWHV 

        70         80         90        100        110        120 
NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW TANEFEKAGF RAVPSCIVRH 

       130        140        150        160        170        180 
SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA 

       190        200        210        220        230        240 
GPTIIEDNCF IGARSEVVEG CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV 

       250        260        270        280 
VAGTMPGKNV PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD 

« Hide

References

[1]"Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C. expand/collapse author list , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23457.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001489 Genomic DNA. Translation: ACO02801.1.
RefSeqYP_002734755.1. NC_012442.1.

3D structure databases

ProteinModelPortalC0RMG8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING546272.BMEA_B1014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO02801; ACO02801; BMEA_B1014.
GeneID7671510.
KEGGbmi:BMEA_B1014.
PATRIC17842414. VBIBruMel14466_3301.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMAWVTVGSC.
OrthoDBEOG68H8BV.
ProtClustDBPRK11830.

Enzyme and pathway databases

BioCycBMEL546272:GJOX-3172-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPD_BRUMB
AccessionPrimary (citable) accession number: C0RMG8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways