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C0RMG8

- DAPD_BRUMB

UniProt

C0RMG8 - DAPD_BRUMB

Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation

    GO - Molecular functioni

    1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciBMEL546272:GJOX-3172-MONOMER.
    UniPathwayiUPA00034; UER00019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
    Alternative name(s):
    Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
    Short name:
    THDP succinyltransferaseUniRule annotation
    Short name:
    THP succinyltransferaseUniRule annotation
    Short name:
    Tetrahydropicolinate succinylaseUniRule annotation
    Gene namesi
    Name:dapDUniRule annotation
    Ordered Locus Names:BMEA_B1014
    OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
    Taxonomic identifieri546272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000001748: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_1000148582Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi546272.BMEA_B1014.

    Structurei

    3D structure databases

    ProteinModelPortaliC0RMG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2171.
    HOGENOMiHOG000003295.
    KOiK00674.
    OMAiYIARNTV.
    OrthoDBiEOG68H8BV.

    Family and domain databases

    Gene3Di1.10.166.10. 1 hit.
    HAMAPiMF_00811. DapD.
    InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
    PfamiPF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR00965. dapD. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0RMG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA    50
    EKQADGNWHV NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW 100
    TANEFEKAGF RAVPSCIVRH SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW 150
    ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA GPTIIEDNCF IGARSEVVEG 200
    CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV VAGTMPGKNV 250
    PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD 284
    Length:284
    Mass (Da):30,726
    Last modified:May 5, 2009 - v1
    Checksum:i48231A894992DA4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001489 Genomic DNA. Translation: ACO02801.1.
    RefSeqiYP_002734755.1. NC_012442.1.

    Genome annotation databases

    EnsemblBacteriaiACO02801; ACO02801; BMEA_B1014.
    GeneIDi7671510.
    KEGGibmi:BMEA_B1014.
    PATRICi17842414. VBIBruMel14466_3301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001489 Genomic DNA. Translation: ACO02801.1 .
    RefSeqi YP_002734755.1. NC_012442.1.

    3D structure databases

    ProteinModelPortali C0RMG8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 546272.BMEA_B1014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO02801 ; ACO02801 ; BMEA_B1014 .
    GeneIDi 7671510.
    KEGGi bmi:BMEA_B1014.
    PATRICi 17842414. VBIBruMel14466_3301.

    Phylogenomic databases

    eggNOGi COG2171.
    HOGENOMi HOG000003295.
    KOi K00674.
    OMAi YIARNTV.
    OrthoDBi EOG68H8BV.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00019 .
    BioCyci BMEL546272:GJOX-3172-MONOMER.

    Family and domain databases

    Gene3Di 1.10.166.10. 1 hit.
    HAMAPi MF_00811. DapD.
    InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
    Pfami PF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR00965. dapD. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
      Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
      , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23457.

    Entry informationi

    Entry nameiDAPD_BRUMB
    AccessioniPrimary (citable) accession number: C0RMG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3