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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation

GO - Molecular functioni

  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciBMEL546272:GJOX-3172-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BMEA_B1014
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001748: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_1000148582Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi546272.BMEA_B1014.

Structurei

3D structure databases

ProteinModelPortaliC0RMG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2171.
HOGENOMiHOG000003295.
KOiK00674.
OMAiQVPCALI.
OrthoDBiEOG68H8BV.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD.
InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamiPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0RMG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA
60 70 80 90 100
EKQADGNWHV NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW
110 120 130 140 150
TANEFEKAGF RAVPSCIVRH SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW
160 170 180 190 200
ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA GPTIIEDNCF IGARSEVVEG
210 220 230 240 250
CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV VAGTMPGKNV
260 270 280
PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD
Length:284
Mass (Da):30,726
Last modified:May 5, 2009 - v1
Checksum:i48231A894992DA4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1.
RefSeqiYP_002734755.1. NC_012442.1.

Genome annotation databases

EnsemblBacteriaiACO02801; ACO02801; BMEA_B1014.
GeneIDi7671510.
KEGGibmi:BMEA_B1014.
PATRICi17842414. VBIBruMel14466_3301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1.
RefSeqiYP_002734755.1. NC_012442.1.

3D structure databases

ProteinModelPortaliC0RMG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi546272.BMEA_B1014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO02801; ACO02801; BMEA_B1014.
GeneIDi7671510.
KEGGibmi:BMEA_B1014.
PATRICi17842414. VBIBruMel14466_3301.

Phylogenomic databases

eggNOGiCOG2171.
HOGENOMiHOG000003295.
KOiK00674.
OMAiQVPCALI.
OrthoDBiEOG68H8BV.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00019.
BioCyciBMEL546272:GJOX-3172-MONOMER.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD.
InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamiPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
    Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
    , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23457.

Entry informationi

Entry nameiDAPD_BRUMB
AccessioniPrimary (citable) accession number: C0RMG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.