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C0RMG8

- DAPD_BRUMB

UniProt

C0RMG8 - DAPD_BRUMB

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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111SubstrateUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation

GO - Molecular functioni

  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciBMEL546272:GJOX-3172-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BMEA_B1014
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001748: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_1000148582Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi546272.BMEA_B1014.

Structurei

3D structure databases

ProteinModelPortaliC0RMG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2171.
HOGENOMiHOG000003295.
KOiK00674.
OMAiYIARNTV.
OrthoDBiEOG68H8BV.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD.
InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamiPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0RMG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA
60 70 80 90 100
EKQADGNWHV NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW
110 120 130 140 150
TANEFEKAGF RAVPSCIVRH SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW
160 170 180 190 200
ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA GPTIIEDNCF IGARSEVVEG
210 220 230 240 250
CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV VAGTMPGKNV
260 270 280
PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD
Length:284
Mass (Da):30,726
Last modified:May 5, 2009 - v1
Checksum:i48231A894992DA4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1.
RefSeqiYP_002734755.1. NC_012442.1.

Genome annotation databases

EnsemblBacteriaiACO02801; ACO02801; BMEA_B1014.
GeneIDi7671510.
KEGGibmi:BMEA_B1014.
PATRICi17842414. VBIBruMel14466_3301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1 .
RefSeqi YP_002734755.1. NC_012442.1.

3D structure databases

ProteinModelPortali C0RMG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546272.BMEA_B1014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO02801 ; ACO02801 ; BMEA_B1014 .
GeneIDi 7671510.
KEGGi bmi:BMEA_B1014.
PATRICi 17842414. VBIBruMel14466_3301.

Phylogenomic databases

eggNOGi COG2171.
HOGENOMi HOG000003295.
KOi K00674.
OMAi YIARNTV.
OrthoDBi EOG68H8BV.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00019 .
BioCyci BMEL546272:GJOX-3172-MONOMER.

Family and domain databases

Gene3Di 1.10.166.10. 1 hit.
HAMAPi MF_00811. DapD.
InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
Pfami PF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR00965. dapD. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
    Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
    , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23457.

Entry informationi

Entry nameiDAPD_BRUMB
AccessioniPrimary (citable) accession number: C0RMG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3