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C0RMG8

- DAPD_BRUMB

UniProt

C0RMG8 - DAPD_BRUMB

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Protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Gene
dapD, BMEA_B1014
Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111Substrate By similarity
Binding sitei148 – 1481Substrate By similarity

GO - Molecular functioni

  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciBMEL546272:GJOX-3172-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC:2.3.1.117)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name:
THDP succinyltransferase
Short name:
THP succinyltransferase
Short name:
Tetrahydropicolinate succinylase
Gene namesi
Name:dapD
Ordered Locus Names:BMEA_B1014
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001748: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation
PRO_1000148582Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi546272.BMEA_B1014.

Structurei

3D structure databases

ProteinModelPortaliC0RMG8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2171.
HOGENOMiHOG000003295.
KOiK00674.
OMAiYIARNTV.
OrthoDBiEOG68H8BV.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD.
InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamiPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0RMG8-1 [UniParc]FASTAAdd to Basket

« Hide

MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA    50
EKQADGNWHV NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW 100
TANEFEKAGF RAVPSCIVRH SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW 150
ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA GPTIIEDNCF IGARSEVVEG 200
CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV VAGTMPGKNV 250
PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD 284
Length:284
Mass (Da):30,726
Last modified:May 5, 2009 - v1
Checksum:i48231A894992DA4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1.
RefSeqiYP_002734755.1. NC_012442.1.

Genome annotation databases

EnsemblBacteriaiACO02801; ACO02801; BMEA_B1014.
GeneIDi7671510.
KEGGibmi:BMEA_B1014.
PATRICi17842414. VBIBruMel14466_3301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001489 Genomic DNA. Translation: ACO02801.1 .
RefSeqi YP_002734755.1. NC_012442.1.

3D structure databases

ProteinModelPortali C0RMG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546272.BMEA_B1014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO02801 ; ACO02801 ; BMEA_B1014 .
GeneIDi 7671510.
KEGGi bmi:BMEA_B1014.
PATRICi 17842414. VBIBruMel14466_3301.

Phylogenomic databases

eggNOGi COG2171.
HOGENOMi HOG000003295.
KOi K00674.
OMAi YIARNTV.
OrthoDBi EOG68H8BV.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00019 .
BioCyci BMEL546272:GJOX-3172-MONOMER.

Family and domain databases

Gene3Di 1.10.166.10. 1 hit.
HAMAPi MF_00811. DapD.
InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
Pfami PF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR00965. dapD. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
    Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
    , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23457.

Entry informationi

Entry nameiDAPD_BRUMB
AccessioniPrimary (citable) accession number: C0RMG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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