Skip Header

Contribute Send feedback
Read comments (?) or add your own

C0RJQ8 (C0RJQ8_BRUMB) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Cobyrinic acid A,C-diamide synthase HAMAP-Rule MF_00027
Gene names
Name:cobB HAMAP-Rule MF_00027 EMBL ACO01066.1
Ordered Locus Names:BMEA_A1343
OrganismBrucella melitensis biotype 2 (strain ATCC 23457) [Complete proteome] [HAMAP] EMBL ACO01066.1
Taxonomic identifier546272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity. HAMAP-Rule MF_00027

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis. HAMAP-Rule MF_00027

Sequence similarities

Belongs to the CobB/CobQ family. CobB subfamily. HAMAP-Rule MF_00027

Contains 1 GATase cobBQ-type domain. HAMAP-Rule MF_00027 SAAS SAAS017929

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain244 – 435192GATase cobBQ-type By similarity HAMAP-Rule MF_00027

Sites

Active site3271Nucleophile By similarity HAMAP-Rule MF_00027
Active site4271 By similarity HAMAP-Rule MF_00027

Sequences

Sequence LengthMass (Da)Tools
C0RJQ8 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: AD6DD0D1736FC449

FASTA43647,068
        10         20         30         40         50         60 
MKGFMIAAPA SGSGKTTVTL GLLRALKRRG EVLAPVKAGP DYIDPAYHRA ASGVDCFNLD 

        70         80         90        100        110        120 
PWAMRPELIS ALSSRMTESG ARVLVAEGMM GLFDGAIDGK GSSADLARLL DLPVVLVVDC 

       130        140        150        160        170        180 
ARQSHSIAAL VWGFSQFRKD VLIEGVIFNR VGSPRHEAML RGALAPLGVP VLGALPRDPA 

       190        200        210        220        230        240 
LSLPERHLGL VQADEHAGLE SFLEQAADVM EAHIDMDALQ TIWLRPKRYD AMANVARLKP 

       250        260        270        280        290        300 
LGNRIAVARD DAFAFAYMHL FEGWRRRGAE ISFFSPLADE APKADADAIY LPGGYPELHA 

       310        320        330        340        350        360 
QRLAGASRFR TAIGDAAARG VTVYGECGGY MVLGKTLEDA AGVHHPMLGL LPLETSFARR 

       370        380        390        400        410        420 
KLHLGYRLLE PLGGLPWDMP LKAHEFHYAS IVREEKADRL FRVRDASGEN LGEAGLRVGS 

       430 
VSGSFMHVID FSGEAA

« Hide

References

[1]"Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C. expand/collapse author list , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23457.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001488 Genomic DNA. Translation: ACO01066.1.
RefSeqYP_002733020.1. NC_012441.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING546272.BMEA_A1343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO01066; ACO01066; BMEA_A1343.
GeneID7677070.
KEGGbmi:BMEA_A1343.
PATRIC17838455. VBIBruMel14466_1366.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1797.
HOGENOMHOG000289959.
KOK02224.
OMACWLPGGY.
ProtClustDBPRK01077.

Enzyme and pathway databases

BioCycBMEL546272:GJOX-1306-MONOMER.
UniPathwayUPA00148.

Family and domain databases

HAMAPMF_00027. CobB.
InterProIPR004484. CbiA_synth.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00379. cobB. 1 hit.
PROSITEPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC0RJQ8_BRUMB
AccessionPrimary (citable) accession number: C0RJQ8
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 29, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info