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C0RJG6

- C0RJG6_BRUMB

UniProt

C0RJG6 - C0RJG6_BRUMB

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Protein

Isocitrate dehydrogenase [NADP]

Gene

BMEA_A1243

Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBMEL546272:GJOX-1207-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:BMEA_A1243Imported
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)Imported
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001748: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi546272.BMEA_A1243.

Structurei

3D structure databases

ProteinModelPortaliC0RJG6.
SMRiC0RJG6. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0RJG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD
60 70 80 90 100
ATNDQVTIDA ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICKNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG
160 170 180 190 200
TLTIKFVGED GQTIEHEVYQ APSAGVAMAM YNLDESIREF ARASFNYGLQ
210 220 230 240 250
RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK KIWYEHRLID
260 270 280 290 300
DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL
360 370 380 390 400
KKFAETLEKV CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK

AMAA
Length:404
Mass (Da):45,455
Last modified:May 5, 2009 - v1
Checksum:i453241CC1A59DC48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001488 Genomic DNA. Translation: ACO00974.1.
RefSeqiYP_002732928.1. NC_012441.1.

Genome annotation databases

EnsemblBacteriaiACO00974; ACO00974; BMEA_A1243.
GeneIDi7677124.
KEGGibmi:BMEA_A1243.
PATRICi17838235. VBIBruMel14466_1261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001488 Genomic DNA. Translation: ACO00974.1 .
RefSeqi YP_002732928.1. NC_012441.1.

3D structure databases

ProteinModelPortali C0RJG6.
SMRi C0RJG6. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546272.BMEA_A1243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO00974 ; ACO00974 ; BMEA_A1243 .
GeneIDi 7677124.
KEGGi bmi:BMEA_A1243.
PATRICi 17838235. VBIBruMel14466_1261.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci BMEL546272:GJOX-1207-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
    Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
    , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23457Imported.

Entry informationi

Entry nameiC0RJG6_BRUMB
AccessioniPrimary (citable) accession number: C0RJG6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3