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C0RHQ3 (BETB_BRUMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:BMEA_A0589
OrganismBrucella melitensis biotype 2 (strain ATCC 23457) [Complete proteome] [HAMAP]
Taxonomic identifier546272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_1000148554

Regions

Nucleotide binding227 – 2326NAD By similarity

Sites

Active site2491 By similarity
Active site2831 By similarity

Sequences

Sequence LengthMass (Da)Tools
C0RHQ3 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: E4B8F12C06BCA654

FASTA48752,025
        10         20         30         40         50         60 
MKAQPKASHF IGGAFVEDKA GKPLPVIYPA TGEEIASLYS ATPGIIEAAY AAALKAQGEW 

        70         80         90        100        110        120 
AALKPVERGR ILRRTAEILR EKNRKLSKLE TLDTGKALQE TLVADAASAA DALEFFGGII 

       130        140        150        160        170        180 
SGFNGEFVEL GGSFAYTRRE ALGICVGIGA WNYPIQIAAW KSAPALAMGN AFIFKPSENT 

       190        200        210        220        230        240 
PLSALALAEA YKEAGLPDGL FNVVQGYGDV GAALVNHRLT AKVSLTGSVP TGRRIMAQAG 

       250        260        270        280        290        300 
EQLKHVTMEL GGKSPLIVFD DADLESAIGG AMLGNFYSTG QVCSNGTRVF VHKNIRERFI 

       310        320        330        340        350        360 
ERLVERTRKI RIGDPFDEAT QMGPLISAAQ RDKVLSYIKK GKAEGATLAC GGGVPKLQGF 

       370        380        390        400        410        420 
DKGFFIEPTV FADVTDTMTI AREEIFGPVM SVLEFSDEDE VIARANDSEF GLAAGVFTAD 

       430        440        450        460        470        480 
LSRGHHVIGQ IKAGTCWINA YNLTSVEVPF GGYKQSGIGR ENGIAALAHY SQIKTVYVEM 


GKVDSPY

« Hide

References

[1]"Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C. expand/collapse author list , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23457.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001488 Genomic DNA. Translation: ACO00361.1.
RefSeqYP_002732315.1. NC_012441.1.

3D structure databases

ProteinModelPortalC0RHQ3.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0RHQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7678346.
GenomeReviewsGene locus BMEA_A0589 in contig CP001488_GR.
KEGGbmi:BMEA_A0589.
PATRIC17836894. VBIBruMel14466_0604.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIMRERNR.
ProtClustDBPRK13252.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_BRUMB
AccessionPrimary (citable) accession number: C0RHQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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