ID   C0RGQ4_BRUMB            Unreviewed;       505 AA.
AC   C0RGQ4;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=EPTC-inducible aldehyde dehydrogenase {ECO:0000313|EMBL:ACO00012.1};
GN   OrderedLocusNames=BMEA_A0211 {ECO:0000313|EMBL:ACO00012.1};
OS   Brucella melitensis biotype 2 (strain ATCC 23457).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=546272 {ECO:0000313|EMBL:ACO00012.1, ECO:0000313|Proteomes:UP000001748};
RN   [1] {ECO:0000313|Proteomes:UP000001748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23457 {ECO:0000313|Proteomes:UP000001748};
RA   Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J.,
RA   Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E.,
RA   Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C., Tapia R.,
RA   Han C., Detter J.C., Bruce D., Brettin T.S.;
RT   "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP001488; ACO00012.1; -; Genomic_DNA.
DR   RefSeq; WP_004686637.1; NC_012441.1.
DR   AlphaFoldDB; C0RGQ4; -.
DR   KEGG; bmi:BMEA_A0211; -.
DR   HOGENOM; CLU_005391_0_0_5; -.
DR   Proteomes; UP000001748; Chromosome I.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07116; ALDH_ACDHII-AcoD; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          26..492
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   505 AA;  55281 MW;  8A2B9CFF5CDE88B6 CRC64;
     MNKVEFSRTV KPAFAKRYGN FIGGKWVEPR SGRYFENTSP VNGQVLCEVA RSDAADVEAA
     LDAAHAAREL WGRTSVAERA LILNRIADRI EENLPALAAA ETWDNGKPIR ETTNADLPLA
     VDHFRYFAGV IRAQEGGISE IDHDTVAYHF HEPLGVVGQI IPWNFPLLMA TWKLAPALAA
     GNCVVLKPAE QTPASILVLM ELIADILPPG VVNIVNGFGL EAGKPLASSP RIAKIAFTGE
     TTTGRLIMQY ASQNLIPVTL ELGGKSPNIF FKDVAAEDDD FLDKAIEGFV MFALNQGEVC
     TCPSRALIQE SIYDRFMEKA LKRVEAFVQG DPLDPATMIG AQASSEQLEK ILSYLDIGRQ
     EGAEVLAGGE RNMLPGDLAG GYYVKPTVFK GHNKMRIFQE EIFGPVVSVA TFKDDAEALS
     IANDTLYGLG AGIWTRDGTR AYRFGRAIKA GRVWTNCYHA YPAQAAFGGY KQSGIGRENH
     LKMLDHYQNT KNMLVSYSPK KLGFF
//