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C0RGH3

- PNCB_BRUMB

UniProt

C0RGH3 - PNCB_BRUMB

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, BMEA_A0119
Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBMEL546272:GJOX-112-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:BMEA_A0119
OrganismiBrucella melitensis biotype 2 (strain ATCC 23457)
Taxonomic identifieri546272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000001748: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_1000146835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi546272.BMEA_A0119.

Structurei

3D structure databases

ProteinModelPortaliC0RGH3.
SMRiC0RGH3. Positions 1-426.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

C0RGH3-1 [UniParc]FASTAAdd to Basket

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MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS    50
LINRTSSVRL ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI 100
FQPEFLAWLH DFQLPEYELR RKDGQYELHF HGPWTHTTMW EIPALAIINE 150
LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV ERLRQLPDLK ISDFGTRRRH 200
SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN AHELPMVLAA 250
LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 300
WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR 350
HFEGRVRMGF GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK 400
LSDNPQKATG DPKEVARYLR FFGNEERVEQ LVRV 434
Length:434
Mass (Da):49,909
Last modified:May 5, 2009 - v1
Checksum:iA11BE6474B58F0C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001488 Genomic DNA. Translation: ACN99930.1.
RefSeqiYP_002731885.1. NC_012441.1.

Genome annotation databases

EnsemblBacteriaiACN99930; ACN99930; BMEA_A0119.
GeneIDi7676544.
KEGGibmi:BMEA_A0119.
PATRICi17835913. VBIBruMel14466_0121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001488 Genomic DNA. Translation: ACN99930.1 .
RefSeqi YP_002731885.1. NC_012441.1.

3D structure databases

ProteinModelPortali C0RGH3.
SMRi C0RGH3. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546272.BMEA_A0119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN99930 ; ACN99930 ; BMEA_A0119 .
GeneIDi 7676544.
KEGGi bmi:BMEA_A0119.
PATRICi 17835913. VBIBruMel14466_0121.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BMEL546272:GJOX-112-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project."
    Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C.
    , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23457.

Entry informationi

Entry nameiPNCB_BRUMB
AccessioniPrimary (citable) accession number: C0RGH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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