C0RGH3 (PNCB_BRUMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	BMEA_A0119

Organism

Brucella melitensis biotype 2 (strain ATCC 23457) [Complete proteome] [HAMAP]

Taxonomic identifier

546272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000146835

Sequences

	Sequence		Length	Mass (Da)
	C0RGH3 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: A11BE6474B58F0C4	FASTA	434	49,909
	10 20 30 40 50 60 MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS LINRTSSVRL 70 80 90 100 110 120 ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI FQPEFLAWLH DFQLPEYELR 130 140 150 160 170 180 RKDGQYELHF HGPWTHTTMW EIPALAIINE LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV 190 200 210 220 230 240 ERLRQLPDLK ISDFGTRRRH SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN 250 260 270 280 290 300 AHELPMVLAA LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 310 320 330 340 350 360 WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR HFEGRVRMGF 370 380 390 400 410 420 GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK LSDNPQKATG DPKEVARYLR 430 FFGNEERVEQ LVRV

References

[1]

"Brucella melitensis ATCC 23457 whole genome shotgun sequencing project." Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C. , Tapia R., Han C., Detter J.C., Bruce D., Brettin T.S. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23457.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001488 Genomic DNA. Translation: ACN99930.1.
RefSeq	YP_002731885.1. NC_012441.1.
3D structure databases
ProteinModelPortal	C0RGH3.
SMR	C0RGH3. Positions 1-426.
ModBase	Search...
Protein-protein interaction databases
STRING	C0RGH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7676544.
GenomeReviews	Gene locus BMEA_A0119 in contig CP001488_GR.
KEGG	bmi:BMEA_A0119.
PATRIC	17835913. VBIBruMel14466_0121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
KO	K00763.
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BRUMB

Accession

Primary (citable) accession number: C0RGH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program