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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi251Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 2UniRule annotation1
Metal bindingi267Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 183ATPUniRule annotationAdd BLAST54

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSP66084:G1GUS-184-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:WRi_001550
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000001293 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002022081 – 317D-alanine--D-alanine ligaseAdd BLAST317

Structurei

3D structure databases

ProteinModelPortaliC0R5F9
SMRiC0R5F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 299ATP-graspUniRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000011592
KOiK01921
OMAiYETKYTE

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

C0R5F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMIPTIAIL SGGFSCEREI SLMSGKAVKK ALDSLSYNAI EIDVDSNIAE
60 70 80 90 100
KLKKINPGLA FIALHGPYGE DGCIQGLLEI LGIKYTHSGV MASAVAINKV
110 120 130 140 150
MSKHIFRSLN IDTPKGYVIS REDVLKNNIK IDYPYVLKPI NEGSSIGVYI
160 170 180 190 200
IFSHEDYLEL KDNSSTIMEK MIVEEYIPGI ELHTAVLLDE AIGTIEVRPK
210 220 230 240 250
NKFYDYEAKY TDGFAEHIFP AKIPDNIYKM TLEHALKIHQ FLGCKTISRS
260 270 280 290 300
DFRYNPKNNT LKMLEINTHP GFTELSLVPE IAKLAKGINF NELVKIIIED
310
SLQHKNIRDL SHVEQYY
Length:317
Mass (Da):35,727
Last modified:May 5, 2009 - v1
Checksum:i987545685EEFAAE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA Translation: ACN95001.1
RefSeqiWP_012673074.1, NZ_MKIF01000123.1

Genome annotation databases

EnsemblBacteriaiACN95001; ACN95001; WRi_001550
KEGGiwri:WRi_001550

Similar proteinsi

Entry informationi

Entry nameiDDL_WOLWR
AccessioniPrimary (citable) accession number: C0R5F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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