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C0R5A2

- DEF_WOLWR

UniProt

C0R5A2 - DEF_WOLWR

Protein

Peptide deformylase

Gene

def

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021IronUniRule annotation
    Metal bindingi144 – 1441IronUniRule annotation
    Active sitei145 – 1451UniRule annotation
    Metal bindingi148 – 1481IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciWSP66084:GHAN-79-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:WRi_000890
    OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
    Taxonomic identifieri66084 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000001293: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Peptide deformylasePRO_1000123549Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66084.WRi_000890.

    Structurei

    3D structure databases

    ProteinModelPortaliC0R5A2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiELLAICI.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0R5A2-1 [UniParc]FASTAAdd to Basket

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    MSILPIVIAP DERLITRASE VTDINDKIKE LVNDMFETMY DAEGLGLAAV    50
    QVGVLKRIFV VDVQLETIEN EPAGYGSTGK FYMINPEITE LSDEQVILKE 100
    GCLSIPEQSH EIKRPKYLTV KYKDLDNEEQ TLKASGWLAR CIQHELDHLN 150
    GILYIRHLSK LKYDMAITKA QKIKKQHEQ 179
    Length:179
    Mass (Da):20,443
    Last modified:May 5, 2009 - v1
    Checksum:i434DD250BBE63B3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001391 Genomic DNA. Translation: ACN94944.1.
    RefSeqiYP_002726735.1. NC_012416.1.

    Genome annotation databases

    EnsemblBacteriaiACN94944; ACN94944; WRi_000890.
    GeneIDi7668840.
    KEGGiwri:WRi_000890.
    PATRICi24034152. VBIWolSp98304_0095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001391 Genomic DNA. Translation: ACN94944.1 .
    RefSeqi YP_002726735.1. NC_012416.1.

    3D structure databases

    ProteinModelPortali C0R5A2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66084.WRi_000890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN94944 ; ACN94944 ; WRi_000890 .
    GeneIDi 7668840.
    KEGGi wri:WRi_000890.
    PATRICi 24034152. VBIWolSp98304_0095.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi ELLAICI.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci WSP66084:GHAN-79-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: wRi.

    Entry informationi

    Entry nameiDEF_WOLWR
    AccessioniPrimary (citable) accession number: C0R5A2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3