Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C0R573

- SYL_WOLWR

UniProt

C0R573 - SYL_WOLWR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSP66084:GHAN-48-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WRi_000480
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000001293: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Leucine--tRNA ligasePRO_1000199234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66084.WRi_000480.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi611 – 6155"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0R573-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDFKNVER FCQDKWDFSV SKSSKQEKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
AIGDVIARYK RARGFEVLHP IGWDAFGLPA ENAARDNNIS PEIWTKENID
110 120 130 140 150
NMRAQLKSIG LSYNWNRELS TCEPNYYTHE QKFFLDFLKH GLAYRKESWV
160 170 180 190 200
NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLSQWFLKIT DFAEDLLKCL
210 220 230 240 250
QSLKNWPEKV KTMQERWIGK SEGATIEFEV VGLNKKLKVF TTYPHTLFGA
260 270 280 290 300
SFCAVAAEHP IVQDLKNGSS VVIPVLDTGI QEIKSKREND EKIGVYTGLN
310 320 330 340 350
VKHPFLDKEL PLYIANFVLM EYGEGAIFGC PAHDQRDFEF AQKYNLPIIP
360 370 380 390 400
VISSAHLGVI PARDQNSYNG SQCQATQMTK EAYTGDGVMF NSEFLNGLMV
410 420 430 440 450
SEAKEVIIKK LKEKGIGKKT TNYRLHDWGV SRQRYWGCPI PIIYCKDCGT
460 470 480 490 500
VPVPEKDLPV ILPADVEFTS GGNPLDKHPT WKFVDCPKCG KQAERETDTF
510 520 530 540 550
DTFFESSWYF AAFCSEDKSI DKDACNRFMP VDYYIGGIEH AILHLLYSRF
560 570 580 590 600
FCRALTKCGY FDIKEPFSTL ITQGMVCHAT YKDENGKWLF LAEAKELIAR
610 620 630 640 650
GTKVQVGKVE KMSKSKKNTV DPNFIIEKYG ADTARLFVLS DTPPEKDMEW
660 670 680 690 700
SDDGVEGCSR YVNKLWRMVM QLKPVNMHYD NKSVTGGLLE YRKKIHKLLH
710 720 730 740 750
GLTDDLENCR LNCVVAKFRE MTNLIAEIDV AAGKSLIDEG ICILIRVIEP
760 770 780 790 800
FMPHLAESLW QEIGGQPWPK ADESLLVDDT VTIAVQINGK LRATIEVAIN
810 820 830
LPQEELKKIA IDSVSSKIDQ NKVRTVYAVP NKIVNIVI
Length:838
Mass (Da):95,498
Last modified:May 5, 2009 - v1
Checksum:i59AC758234BF408D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN94915.1.
RefSeqiWP_012673049.1. NC_012416.1.
YP_002726706.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN94915; ACN94915; WRi_000480.
GeneIDi7668806.
KEGGiwri:WRi_000480.
PATRICi24034060. VBIWolSp98304_0049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN94915.1 .
RefSeqi WP_012673049.1. NC_012416.1.
YP_002726706.1. NC_012416.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66084.WRi_000480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN94915 ; ACN94915 ; WRi_000480 .
GeneIDi 7668806.
KEGGi wri:WRi_000480.
PATRICi 24034060. VBIWolSp98304_0049.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci WSP66084:GHAN-48-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wRi.

Entry informationi

Entry nameiSYL_WOLWR
AccessioniPrimary (citable) accession number: C0R573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3