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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei614ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSP66084:G1GUS-59-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WRi_000480
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000001293 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001992341 – 838Leucine--tRNA ligaseAdd BLAST838

Proteomic databases

PRIDEiC0R573

Structurei

3D structure databases

SMRiC0R573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi611 – 615"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C0R573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFKNVER FCQDKWDFSV SKSSKQEKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
AIGDVIARYK RARGFEVLHP IGWDAFGLPA ENAARDNNIS PEIWTKENID
110 120 130 140 150
NMRAQLKSIG LSYNWNRELS TCEPNYYTHE QKFFLDFLKH GLAYRKESWV
160 170 180 190 200
NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLSQWFLKIT DFAEDLLKCL
210 220 230 240 250
QSLKNWPEKV KTMQERWIGK SEGATIEFEV VGLNKKLKVF TTYPHTLFGA
260 270 280 290 300
SFCAVAAEHP IVQDLKNGSS VVIPVLDTGI QEIKSKREND EKIGVYTGLN
310 320 330 340 350
VKHPFLDKEL PLYIANFVLM EYGEGAIFGC PAHDQRDFEF AQKYNLPIIP
360 370 380 390 400
VISSAHLGVI PARDQNSYNG SQCQATQMTK EAYTGDGVMF NSEFLNGLMV
410 420 430 440 450
SEAKEVIIKK LKEKGIGKKT TNYRLHDWGV SRQRYWGCPI PIIYCKDCGT
460 470 480 490 500
VPVPEKDLPV ILPADVEFTS GGNPLDKHPT WKFVDCPKCG KQAERETDTF
510 520 530 540 550
DTFFESSWYF AAFCSEDKSI DKDACNRFMP VDYYIGGIEH AILHLLYSRF
560 570 580 590 600
FCRALTKCGY FDIKEPFSTL ITQGMVCHAT YKDENGKWLF LAEAKELIAR
610 620 630 640 650
GTKVQVGKVE KMSKSKKNTV DPNFIIEKYG ADTARLFVLS DTPPEKDMEW
660 670 680 690 700
SDDGVEGCSR YVNKLWRMVM QLKPVNMHYD NKSVTGGLLE YRKKIHKLLH
710 720 730 740 750
GLTDDLENCR LNCVVAKFRE MTNLIAEIDV AAGKSLIDEG ICILIRVIEP
760 770 780 790 800
FMPHLAESLW QEIGGQPWPK ADESLLVDDT VTIAVQINGK LRATIEVAIN
810 820 830
LPQEELKKIA IDSVSSKIDQ NKVRTVYAVP NKIVNIVI
Length:838
Mass (Da):95,498
Last modified:May 5, 2009 - v1
Checksum:i59AC758234BF408D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA Translation: ACN94915.1
RefSeqiWP_012673049.1, NZ_MKIF01000170.1

Genome annotation databases

EnsemblBacteriaiACN94915; ACN94915; WRi_000480
KEGGiwri:WRi_000480

Similar proteinsi

Entry informationi

Entry nameiSYL_WOLWR
AccessioniPrimary (citable) accession number: C0R573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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