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C0R573

- SYL_WOLWR

UniProt

C0R573 - SYL_WOLWR

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Protein
Leucine--tRNA ligase
Gene
leuS, WRi_000480
Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWSP66084:GHAN-48-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:WRi_000480
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000001293: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Leucine--tRNA ligaseUniRule annotation
PRO_1000199234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66084.WRi_000480.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotation
Add
BLAST
Motifi611 – 6155"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0R573-1 [UniParc]FASTAAdd to Basket

« Hide

MKYDFKNVER FCQDKWDFSV SKSSKQEKCY VLEMFPYPSG KIHMGHLRNY    50
AIGDVIARYK RARGFEVLHP IGWDAFGLPA ENAARDNNIS PEIWTKENID 100
NMRAQLKSIG LSYNWNRELS TCEPNYYTHE QKFFLDFLKH GLAYRKESWV 150
NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLSQWFLKIT DFAEDLLKCL 200
QSLKNWPEKV KTMQERWIGK SEGATIEFEV VGLNKKLKVF TTYPHTLFGA 250
SFCAVAAEHP IVQDLKNGSS VVIPVLDTGI QEIKSKREND EKIGVYTGLN 300
VKHPFLDKEL PLYIANFVLM EYGEGAIFGC PAHDQRDFEF AQKYNLPIIP 350
VISSAHLGVI PARDQNSYNG SQCQATQMTK EAYTGDGVMF NSEFLNGLMV 400
SEAKEVIIKK LKEKGIGKKT TNYRLHDWGV SRQRYWGCPI PIIYCKDCGT 450
VPVPEKDLPV ILPADVEFTS GGNPLDKHPT WKFVDCPKCG KQAERETDTF 500
DTFFESSWYF AAFCSEDKSI DKDACNRFMP VDYYIGGIEH AILHLLYSRF 550
FCRALTKCGY FDIKEPFSTL ITQGMVCHAT YKDENGKWLF LAEAKELIAR 600
GTKVQVGKVE KMSKSKKNTV DPNFIIEKYG ADTARLFVLS DTPPEKDMEW 650
SDDGVEGCSR YVNKLWRMVM QLKPVNMHYD NKSVTGGLLE YRKKIHKLLH 700
GLTDDLENCR LNCVVAKFRE MTNLIAEIDV AAGKSLIDEG ICILIRVIEP 750
FMPHLAESLW QEIGGQPWPK ADESLLVDDT VTIAVQINGK LRATIEVAIN 800
LPQEELKKIA IDSVSSKIDQ NKVRTVYAVP NKIVNIVI 838
Length:838
Mass (Da):95,498
Last modified:May 5, 2009 - v1
Checksum:i59AC758234BF408D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN94915.1.
RefSeqiWP_012673049.1. NC_012416.1.
YP_002726706.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN94915; ACN94915; WRi_000480.
GeneIDi7668806.
KEGGiwri:WRi_000480.
PATRICi24034060. VBIWolSp98304_0049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN94915.1 .
RefSeqi WP_012673049.1. NC_012416.1.
YP_002726706.1. NC_012416.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 66084.WRi_000480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN94915 ; ACN94915 ; WRi_000480 .
GeneIDi 7668806.
KEGGi wri:WRi_000480.
PATRICi 24034060. VBIWolSp98304_0049.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci WSP66084:GHAN-48-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wRi.

Entry informationi

Entry nameiSYL_WOLWR
AccessioniPrimary (citable) accession number: C0R573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi