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C0R4Y0

- MDH_WOLWR

UniProt

C0R4Y0 - MDH_WOLWR

Protein

Malate dehydrogenase

Gene

mdh

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADUniRule annotation
    Binding sitei85 – 851SubstrateUniRule annotation
    Binding sitei91 – 911SubstrateUniRule annotation
    Binding sitei98 – 981NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciWSP66084:GHAN-1224-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:WRi_012940
    OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
    Taxonomic identifieri66084 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000001293: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Malate dehydrogenasePRO_1000191660Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66084.WRi_012940.

    Structurei

    3D structure databases

    ProteinModelPortaliC0R4Y0.
    SMRiC0R4Y0. Positions 3-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0R4Y0-1 [UniParc]FASTAAdd to Basket

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    MTVQRKKISL IGAGNIGGTL THMIALRELG DVVLLDISDG IPQGKALDIA    50
    ESSPIDGFNV NITGTNRYED IKNSDAIIIT AGIARKPGMS RDDLLQTNAK 100
    VMKEVGENIK KYSPNAFVIV VTNPLDAMVS VVHKFSNLPT NMIVGMAGVL 150
    DSSRFRYFLA SELNISVEDI SAFVLGGHGD TMVPLINCAS VAGVPLTQII 200
    DMGLITQKKV DEIVERTRNG GKEIVDLLKS GSAYYAPASS AICMLESYLK 250
    DKRRILPCAA YLNGEYGVEE LFIGVPVIIG KNGIEKILEV KMNDSEQEMF 300
    NKSVNSVREL VKSLGS 316
    Length:316
    Mass (Da):34,138
    Last modified:May 5, 2009 - v1
    Checksum:iB3C9BE5C90967049
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001391 Genomic DNA. Translation: ACN95972.1.
    RefSeqiYP_002727763.1. NC_012416.1.

    Genome annotation databases

    EnsemblBacteriaiACN95972; ACN95972; WRi_012940.
    GeneIDi7670005.
    KEGGiwri:WRi_012940.
    PATRICi24036960. VBIWolSp98304_1466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001391 Genomic DNA. Translation: ACN95972.1 .
    RefSeqi YP_002727763.1. NC_012416.1.

    3D structure databases

    ProteinModelPortali C0R4Y0.
    SMRi C0R4Y0. Positions 3-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66084.WRi_012940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN95972 ; ACN95972 ; WRi_012940 .
    GeneIDi 7670005.
    KEGGi wri:WRi_012940.
    PATRICi 24036960. VBIWolSp98304_1466.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci WSP66084:GHAN-1224-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: wRi.

    Entry informationi

    Entry nameiMDH_WOLWR
    AccessioniPrimary (citable) accession number: C0R4Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3