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Protein

Malate dehydrogenase

Gene

mdh

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei98NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:WRi_012940
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000001293 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916601 – 316Malate dehydrogenaseAdd BLAST316

Structurei

3D structure databases

ProteinModelPortaliC0R4Y0.
SMRiC0R4Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

C0R4Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVQRKKISL IGAGNIGGTL THMIALRELG DVVLLDISDG IPQGKALDIA
60 70 80 90 100
ESSPIDGFNV NITGTNRYED IKNSDAIIIT AGIARKPGMS RDDLLQTNAK
110 120 130 140 150
VMKEVGENIK KYSPNAFVIV VTNPLDAMVS VVHKFSNLPT NMIVGMAGVL
160 170 180 190 200
DSSRFRYFLA SELNISVEDI SAFVLGGHGD TMVPLINCAS VAGVPLTQII
210 220 230 240 250
DMGLITQKKV DEIVERTRNG GKEIVDLLKS GSAYYAPASS AICMLESYLK
260 270 280 290 300
DKRRILPCAA YLNGEYGVEE LFIGVPVIIG KNGIEKILEV KMNDSEQEMF
310
NKSVNSVREL VKSLGS
Length:316
Mass (Da):34,138
Last modified:May 5, 2009 - v1
Checksum:iB3C9BE5C90967049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA. Translation: ACN95972.1.
RefSeqiWP_007548577.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN95972; ACN95972; WRi_012940.
GeneIDi29555756.
KEGGiwri:WRi_012940.

Similar proteinsi

Entry informationi

Entry nameiMDH_WOLWR
AccessioniPrimary (citable) accession number: C0R4Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: August 30, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families