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C0R4N2

- DAPF_WOLWR

UniProt

C0R4N2 - DAPF_WOLWR

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171SubstrateUniRule annotation
Binding sitei45 – 451SubstrateUniRule annotation
Binding sitei63 – 631SubstrateUniRule annotation
Active sitei72 – 721Proton donor/acceptorUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Sitei156 – 1561Important for catalytic activityUniRule annotation
Binding sitei187 – 1871SubstrateUniRule annotation
Sitei205 – 2051Important for catalytic activityUniRule annotation
Active sitei214 – 2141Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciWSP66084:GHAN-1118-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:WRi_011860
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000001293: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Diaminopimelate epimerasePRO_1000124434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 214

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi66084.WRi_011860.

Structurei

3D structure databases

ProteinModelPortaliC0R4N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 743Substrate bindingUniRule annotation
Regioni205 – 2062Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKMRIFNN.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0R4N2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGQNSENFI KMHGTGNNFV IIDSCSANDL NWNYKKIANQ NGCDQVIVIT
60 70 80 90 100
NSSLADCFMH IYNADGSKAE MCGNAARCVG YLLMSEKGTE YITIELVNKR
110 120 130 140 150
ILECFKVGDK SIKVNMGKPL LKWHKIPLST ECDTLHLPIE LEMLKDPVAV
160 170 180 190 200
NIGNPHIVFF VDSVNEIPLQ SLGPKLENHA LFPQKINISI AQVEKSGEIA
210 220 230 240 250
LRVWERGTGI TASCGSAACA ALVTSTLRGY LTVQQTSVNL PGGKLLIEWA
260
NNVFMTGDIG FL
Length:262
Mass (Da):28,665
Last modified:May 5, 2009 - v1
Checksum:iAAF95D34BE4AAEDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA. Translation: ACN95874.1.
RefSeqiWP_012673383.1. NC_012416.1.
YP_002727665.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN95874; ACN95874; WRi_011860.
GeneIDi7669898.
KEGGiwri:WRi_011860.
PATRICi24036716. VBIWolSp98304_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA. Translation: ACN95874.1 .
RefSeqi WP_012673383.1. NC_012416.1.
YP_002727665.1. NC_012416.1.

3D structure databases

ProteinModelPortali C0R4N2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66084.WRi_011860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN95874 ; ACN95874 ; WRi_011860 .
GeneIDi 7669898.
KEGGi wri:WRi_011860.
PATRICi 24036716. VBIWolSp98304_1349.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KMRIFNN.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci WSP66084:GHAN-1118-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wRi.

Entry informationi

Entry nameiDAPF_WOLWR
AccessioniPrimary (citable) accession number: C0R4N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3