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C0R4L0 (HEMH_WOLWR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:WRi_011580
OrganismWolbachia sp. subsp. Drosophila simulans (strain wRi) [Complete proteome] [HAMAP]
Taxonomic identifier66084 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Ferrochelatase HAMAP MF_00323
PRO_1000189997

Sites

Metal binding1931Iron By similarity
Metal binding2731Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
C0R4L0 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 2945FEB20EA25966

FASTA31536,350
        10         20         30         40         50         60 
MKKAVILFNL GGPDSLNAVR PFLFNLFYDR RIINLPNPFR FLLAKFISAK RENTARKIYE 

        70         80         90        100        110        120 
EIGGKSPILE NTKMQANALE LKLNENRNHV HKVFICMRYW RPFADEVIES VKQFDPDEVI 

       130        140        150        160        170        180 
LLPLYPQYST TTTLSSIENW QKNAKRYGLK CNTKMIHRYY DNQDFIEAHT NLIAKYYKLA 

       190        200        210        220        230        240 
RKIGKPRVLF SAHSLPLSII KKGDPYASQV ERSVELIVEK LAINNLDWSI CYQSKIGPVK 

       250        260        270        280        290        300 
WLEPSTESEL LRAKADGVPV VLSPISFVSE HSETLVELDI EYKAIIKDGY YFRVPTLSTD 

       310 
PLFIKCLADL CINLP

« Hide

References

[1]"The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans."
Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y., Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K., Andersson S.G.
Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009) [PubMed: 19307581] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: wRi.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001391 Genomic DNA. Translation: ACN95852.1.
RefSeqYP_002727643.1. NC_012416.1.

3D structure databases

ProteinModelPortalC0R4L0.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0R4L0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBWOLT00000001454; EBWOLP00000001304; EBWOLG00000001454.
GeneID7669872.
GenomeReviewsGene locus WRi_011580 in contig CP001391_GR.
KEGGwri:WRi_011580.
PATRIC24036652. VBIWolSp98304_1318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000031382.
OMALLQMGGP.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_WOLWR
AccessionPrimary (citable) accession number: C0R4L0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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