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C0R407 (C0R407_WOLWR) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ACN95649.1
Ordered Locus Names:WRi_009330
OrganismWolbachia sp. subsp. Drosophila simulans (strain wRi) [Complete proteome] [HAMAP]
Taxonomic identifier66084 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region230 – 2345ACP-binding By similarity HAMAP MF_01815

Sites

Active site971 By similarity HAMAP MF_01815
Active site2291 By similarity HAMAP MF_01815
Active site2591 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
C0R407 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 20C96323DFFA7613

FASTA30232,577
        10         20         30         40         50         60 
MLSNNEIASI VETSDEWIRQ RTGIVQRHIA DEGELTSDLA VNAAKSAIEK AKISVDEIDL 

        70         80         90        100        110        120 
IIVATTTPDK TFPSCATIVQ SKLKCKNAFA FDVQAACSGF IYAVTVADSL IKSNNRIKYA 

       130        140        150        160        170        180 
LVIGAEIMSR IVDWEDRSTC VLFGDGAGAV VMKSEMGRSG IISTNLYSDG NVDILCTNGG 

       190        200        210        220        230        240 
ISSTGDSGKI CMNGREVFKH AVDKLTASVE ETLKCNNLKI TDIDWLIPHQ ANIRIIEAVV 

       250        260        270        280        290        300 
KKLDFPIEKV INTVDKHANT SAASIPLALD YAIQESKIKS GNLVLLISIG AGLTWGSVLL 


HY

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References

[1]"The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans."
Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y., Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K., Andersson S.G.
Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009) [PubMed: 19307581] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001391 Genomic DNA. Translation: ACN95649.1.
RefSeqYP_002727440.1. NC_012416.1.

3D structure databases

ProteinModelPortalC0R407.
SMRC0R407. Positions 2-302.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0R407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBWOLT00000002365; EBWOLP00000002215; EBWOLG00000002365.
GeneID7669654.
GenomeReviewsGene locus WRi_009330 in contig CP001391_GR.
KEGGwri:WRi_009330.
PATRIC24036149. VBIWolSp98304_1070.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000031462.
OMADAYIRGG.
ProtClustDBCLSK739999.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0R407_WOLWR
AccessionPrimary (citable) accession number: C0R407
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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