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C0R3T4

- PNP_WOLWR

UniProt

C0R3T4 - PNP_WOLWR

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, WRi_008390
Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821Magnesium By similarity
Metal bindingi488 – 4881Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciWSP66084:GHAN-791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:WRi_008390
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000001293: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000185763Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66084.WRi_008390.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 60860KH
Add
BLAST
Domaini618 – 68669S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0R3T4-1 [UniParc]FASTAAdd to Basket

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MFKIIKKSIE WGGRTLSLET GKIARQAHGS VVVNYGDTSV LVTVVSKKKE    50
ENVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP 100
LFPEGFHDEI SVVCNLLTYD TVNPPEVPAL IGAVAALAIS GVPFHFTIAG 150
VMVGCDENNN YILNPSVQEM KASSLDLFLS GDENSILMVE SEVKELSEEN 200
VFNAIKFGHE HLKPVIKLIK EFADTIGNKP ESFAPIDASD ITQELEKYGK 250
DFEKAYSQTV KQERVQALEA IRENILNTLK ETGKDEKLIT YAVKNFERSL 300
VREIIRKKSV RIDGRKHDEI RQIEVEVDIL SKTHGSALFT RGNTQALVVT 350
ALGTTQDEQI VDDIEGDRRE HFMLHYNFPS FAVGETSAAR APGRREIGHG 400
KLAWKAIHPV LPDKSEFPYT IRVVSEILES DGSSSMATVC GTSLALMDTG 450
VPIKAPVAGI AMGLIKDKDE YVILSDILGD EDYLGDMDFK VAGTSEGVTA 500
LQMDMKISGI SFEIVEKSLE QAKAGRLHIL EKMNAVISEH SDDVKDHAPR 550
MLSFYIDKDK ISAAIGSKGK NIRSVCERSN AKIEIGDDGK VSVFATSGTE 600
AEIAKSMMID SITELEQGSI VDVKVVRIEK SIVELEFLNG RKGKMHISEV 650
ANEHIDSIES VLKQDDTFKA LVIDFEKGGC PKLSRRRVDQ ETGEFFEGEL 700
YNEERKDGPN DRDNYYNNSF SRKPGGSHHK RPPRPRSGFS NRNRPKFGNN 750
DSSSGFY 757
Length:757
Mass (Da):84,022
Last modified:May 5, 2009 - v1
Checksum:iBACE99C259FE9279
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN95576.1.
RefSeqiWP_012673288.1. NC_012416.1.
YP_002727367.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN95576; ACN95576; WRi_008390.
GeneIDi7669566.
KEGGiwri:WRi_008390.
PATRICi24035907. VBIWolSp98304_0954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001391 Genomic DNA. Translation: ACN95576.1 .
RefSeqi WP_012673288.1. NC_012416.1.
YP_002727367.1. NC_012416.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66084.WRi_008390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN95576 ; ACN95576 ; WRi_008390 .
GeneIDi 7669566.
KEGGi wri:WRi_008390.
PATRICi 24035907. VBIWolSp98304_0954.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci WSP66084:GHAN-791-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: wRi.

Entry informationi

Entry nameiPNP_WOLWR
AccessioniPrimary (citable) accession number: C0R3T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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