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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

pgm

Organism
Wolbachia sp. subsp. Drosophila simulans (strain wRi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (pgm)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Manganese 2UniRule annotation1
Active sitei63Phosphoserine intermediateUniRule annotation1
Metal bindingi63Manganese 2UniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei323SubstrateUniRule annotation1
Metal bindingi390Manganese 1UniRule annotation1
Metal bindingi394Manganese 1UniRule annotation1
Metal bindingi432Manganese 2UniRule annotation1
Metal bindingi433Manganese 2UniRule annotation1
Metal bindingi451Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:pgmImported
Synonyms:gpmIUniRule annotation
Ordered Locus Names:WRi_008330Imported
OrganismiWolbachia sp. subsp. Drosophila simulans (strain wRi)Imported
Taxonomic identifieri66084 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000001293 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC0R3S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 487MetalloenzymeInterPro annotationAdd BLAST484
Domaini88 – 287iPGM_NInterPro annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 152Substrate bindingUniRule annotation2
Regioni253 – 256Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

C0R3S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKSVVLCI LDGWGNGVEN SKYNAISNAN PPCWQYISSN YPKCSLSACG
60 70 80 90 100
TDVGLPGGQI GNSEVGHMNI GSGRVVIQSL QRINQEIGTI ENNVNLQSFI
110 120 130 140 150
SNLKSKNGVC HIMGLVSDGG VHSHQKHIST LANKISQHGI KVVIHAFLDG
160 170 180 190 200
RDTLPNSGKK CIQEFIKSIK GNDIRIATVS GRYYAMDRDN RWERTIEAYE
210 220 230 240 250
AIAFAKAPRH DNAVSLIDEN YQNNITDEFI RPAVIGDYQG IKPEDGVLLA
260 270 280 290 300
NFRADRMIQL ASILLGKTDY AKVAKFSSIL SMMKYKKDLQ IPYIFPPTSF
310 320 330 340 350
ADTLGQTIED NKLQQLRIAE TEKYAHVTFF FNCGKEEPFS GEERILIPSP
360 370 380 390 400
KVQTYDLQPE MSAFELTEKL VEKIHSQEFA LIVVNYANPD MVGHTGNIKA
410 420 430 440 450
AEKAVLAVDD CLAKVLSAVK KSSNTALIVT ADHGNVECMF DEENNTPHTA
460 470 480 490 500
HTLNKVPFIV SCDNLKLRDG RLSDIAPTIL QLLGIKKPDE MTGSSLISCI

TLCHSS
Length:506
Mass (Da):55,720
Last modified:May 5, 2009 - v1
Checksum:iF01D4F94B51C3FCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA. Translation: ACN95571.1.
RefSeqiWP_007548604.1. NC_012416.1.

Genome annotation databases

EnsemblBacteriaiACN95571; ACN95571; WRi_008330.
KEGGiwri:WRi_008330.
PATRICi24035891. VBIWolSp98304_0946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001391 Genomic DNA. Translation: ACN95571.1.
RefSeqiWP_007548604.1. NC_012416.1.

3D structure databases

ProteinModelPortaliC0R3S9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACN95571; ACN95571; WRi_008330.
KEGGiwri:WRi_008330.
PATRICi24035891. VBIWolSp98304_0946.

Phylogenomic databases

HOGENOMiHOG000223664.
KOiK15633.
OMAiLHIATMT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC0R3S9_WOLWR
AccessioniPrimary (citable) accession number: C0R3S9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.