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C0QZQ2

- DEF_BRAHW

UniProt

C0QZQ2 - DEF_BRAHW

Protein

Peptide deformylase

Gene

def

Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi96 – 961IronUniRule annotation
    Metal bindingi138 – 1381IronUniRule annotation
    Active sitei139 – 1391UniRule annotation
    Metal bindingi142 – 1421IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBHYO565034:GJI7-845-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:BHWA1_00847
    OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
    Taxonomic identifieri565034 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
    ProteomesiUP000001803: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Peptide deformylasePRO_1000200716Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi565034.BHWA1_00847.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiMEMVFYP.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0QZQ2-1 [UniParc]FASTAAdd to Basket

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    MLRELVIYGD ERLQKVSEKI EKIDDEILTL IDDMFETMYK ERGVGLAAVQ    50
    IGVLKRLVVI SVPDFDDEEK PDFKLALINP EIIWHNDETE SLEEGCLSFP 100
    EIRDDVARYT QIKVKYLDRE GNEQILDAEN YIAKVLQHEI DHTNGISFID 150
    RLESYQKRRL KRELKELRNN TVRGIKKVNN REMLKNS 187
    Length:187
    Mass (Da):21,993
    Last modified:May 5, 2009 - v1
    Checksum:i23B3C836944D16D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN83340.1.
    RefSeqiWP_012670389.1. NC_012225.1.
    YP_002721044.1. NC_012225.1.

    Genome annotation databases

    EnsemblBacteriaiACN83340; ACN83340; BHWA1_00847.
    GeneIDi7665951.
    KEGGibhy:BHWA1_00847.
    PATRICi21179785. VBIBraHyo62857_0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN83340.1 .
    RefSeqi WP_012670389.1. NC_012225.1.
    YP_002721044.1. NC_012225.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 565034.BHWA1_00847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN83340 ; ACN83340 ; BHWA1_00847 .
    GeneIDi 7665951.
    KEGGi bhy:BHWA1_00847.
    PATRICi 21179785. VBIBraHyo62857_0837.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi MEMVFYP.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci BHYO565034:GJI7-845-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
      Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
      PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49526 / WA1.

    Entry informationi

    Entry nameiDEF_BRAHW
    AccessioniPrimary (citable) accession number: C0QZQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3