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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHYO565034:G1GUM-2334-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BHWA1_02387
OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Taxonomic identifieri565034 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesBrachyspiralesBrachyspiraceaeBrachyspira
Proteomesi
  • UP000001803 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001852481 – 553Formate--tetrahydrofolate ligaseAdd BLAST553

Proteomic databases

PRIDEiC0QX38

Interactioni

Protein-protein interaction databases

STRINGi565034.BHWA1_02387

Structurei

3D structure databases

SMRiC0QX38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

C0QX38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQE CKLERIEKIA EKLNLTDDDY EVYGKYKAKI ELSLLNKLKD
60 70 80 90 100
KKDGKLVLVT AITPTPAGEG KSTVTIGLTQ GLNKIGKNAV AALREPSLGP
110 120 130 140 150
VFGIKGGACG GGYSQIVPME DINLHFNGDF HAISSAHNLI SACIDNHIKQ
160 170 180 190 200
GNELKIDINK IVFKRVLDMN DRALRDIVIG LGGSENGVVR QSSFQITVSS
210 220 230 240 250
EIMAILCLSN SLMDLKEKIG NVIFAYDIND NPLRVKDLKI EGAACTLLKD
260 270 280 290 300
AIKPNLVQTL ENTPVIVHGG PFANIAHGCN SILATKMALK LSDYTITEAG
310 320 330 340 350
FAADLGAEKF LDIKCRLAGL KPNCIVLVAT IRALKHHGGA SDINKEDIEA
360 370 380 390 400
LTKGFENLDK HIENMQKYNV PVVVAINKFV SDTDKEIECI TKHCESKGID
410 420 430 440 450
ISLCEVWAKG GEGAIELSHK VLKAASEESN YKPLYELEKS IKEKIETICK
460 470 480 490 500
EIYSAGEVKF SNKALKMMKK IENMGFGNLP ICISKTQKSI SDNPALLNAP
510 520 530 540 550
KGYTLNIDEI KLASGAGFII AMAGGIIDMP GLPKIPVACN IDIDENGKIK

GLF
Length:553
Mass (Da):59,991
Last modified:May 5, 2009 - v1
Checksum:iE38F6A1EDC7E5F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001357 Genomic DNA Translation: ACN84841.1
RefSeqiWP_012671871.1, NC_012225.1

Genome annotation databases

EnsemblBacteriaiACN84841; ACN84841; BHWA1_02387
KEGGibhy:BHWA1_02387

Similar proteinsi

Entry informationi

Entry nameiFTHS_BRAHW
AccessioniPrimary (citable) accession number: C0QX38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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