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C0QX38

- FTHS_BRAHW

UniProt

C0QX38 - FTHS_BRAHW

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, BHWA1_02387
Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHYO565034:GJI7-2373-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BHWA1_02387
OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Taxonomic identifieri565034 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
ProteomesiUP000001803: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000185248Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565034.BHWA1_02387.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QX38-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQE CKLERIEKIA EKLNLTDDDY EVYGKYKAKI ELSLLNKLKD    50
KKDGKLVLVT AITPTPAGEG KSTVTIGLTQ GLNKIGKNAV AALREPSLGP 100
VFGIKGGACG GGYSQIVPME DINLHFNGDF HAISSAHNLI SACIDNHIKQ 150
GNELKIDINK IVFKRVLDMN DRALRDIVIG LGGSENGVVR QSSFQITVSS 200
EIMAILCLSN SLMDLKEKIG NVIFAYDIND NPLRVKDLKI EGAACTLLKD 250
AIKPNLVQTL ENTPVIVHGG PFANIAHGCN SILATKMALK LSDYTITEAG 300
FAADLGAEKF LDIKCRLAGL KPNCIVLVAT IRALKHHGGA SDINKEDIEA 350
LTKGFENLDK HIENMQKYNV PVVVAINKFV SDTDKEIECI TKHCESKGID 400
ISLCEVWAKG GEGAIELSHK VLKAASEESN YKPLYELEKS IKEKIETICK 450
EIYSAGEVKF SNKALKMMKK IENMGFGNLP ICISKTQKSI SDNPALLNAP 500
KGYTLNIDEI KLASGAGFII AMAGGIIDMP GLPKIPVACN IDIDENGKIK 550
GLF 553
Length:553
Mass (Da):59,991
Last modified:May 5, 2009 - v1
Checksum:iE38F6A1EDC7E5F0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84841.1.
RefSeqiYP_002722545.1. NC_012225.1.

Genome annotation databases

EnsemblBacteriaiACN84841; ACN84841; BHWA1_02387.
GeneIDi7667476.
KEGGibhy:BHWA1_02387.
PATRICi21182816. VBIBraHyo62857_2325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84841.1 .
RefSeqi YP_002722545.1. NC_012225.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 565034.BHWA1_02387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN84841 ; ACN84841 ; BHWA1_02387 .
GeneIDi 7667476.
KEGGi bhy:BHWA1_02387.
PATRICi 21182816. VBIBraHyo62857_2325.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BHYO565034:GJI7-2373-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
    Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
    PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49526 / WA1.

Entry informationi

Entry nameiFTHS_BRAHW
AccessioniPrimary (citable) accession number: C0QX38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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