Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C0QX38

- FTHS_BRAHW

UniProt

C0QX38 - FTHS_BRAHW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHYO565034:GJI7-2373-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BHWA1_02387
OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Taxonomic identifieri565034 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
ProteomesiUP000001803: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_1000185248Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565034.BHWA1_02387.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QX38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE CKLERIEKIA EKLNLTDDDY EVYGKYKAKI ELSLLNKLKD
60 70 80 90 100
KKDGKLVLVT AITPTPAGEG KSTVTIGLTQ GLNKIGKNAV AALREPSLGP
110 120 130 140 150
VFGIKGGACG GGYSQIVPME DINLHFNGDF HAISSAHNLI SACIDNHIKQ
160 170 180 190 200
GNELKIDINK IVFKRVLDMN DRALRDIVIG LGGSENGVVR QSSFQITVSS
210 220 230 240 250
EIMAILCLSN SLMDLKEKIG NVIFAYDIND NPLRVKDLKI EGAACTLLKD
260 270 280 290 300
AIKPNLVQTL ENTPVIVHGG PFANIAHGCN SILATKMALK LSDYTITEAG
310 320 330 340 350
FAADLGAEKF LDIKCRLAGL KPNCIVLVAT IRALKHHGGA SDINKEDIEA
360 370 380 390 400
LTKGFENLDK HIENMQKYNV PVVVAINKFV SDTDKEIECI TKHCESKGID
410 420 430 440 450
ISLCEVWAKG GEGAIELSHK VLKAASEESN YKPLYELEKS IKEKIETICK
460 470 480 490 500
EIYSAGEVKF SNKALKMMKK IENMGFGNLP ICISKTQKSI SDNPALLNAP
510 520 530 540 550
KGYTLNIDEI KLASGAGFII AMAGGIIDMP GLPKIPVACN IDIDENGKIK

GLF
Length:553
Mass (Da):59,991
Last modified:May 5, 2009 - v1
Checksum:iE38F6A1EDC7E5F0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84841.1.
RefSeqiYP_002722545.1. NC_012225.1.

Genome annotation databases

EnsemblBacteriaiACN84841; ACN84841; BHWA1_02387.
GeneIDi7667476.
KEGGibhy:BHWA1_02387.
PATRICi21182816. VBIBraHyo62857_2325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84841.1 .
RefSeqi YP_002722545.1. NC_012225.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 565034.BHWA1_02387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN84841 ; ACN84841 ; BHWA1_02387 .
GeneIDi 7667476.
KEGGi bhy:BHWA1_02387.
PATRICi 21182816. VBIBraHyo62857_2325.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BHYO565034:GJI7-2373-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
    Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
    PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49526 / WA1.

Entry informationi

Entry nameiFTHS_BRAHW
AccessioniPrimary (citable) accession number: C0QX38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 1, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3