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C0QX38 (FTHS_BRAHW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:BHWA1_02387
OrganismBrachyspira hyodysenteriae (strain ATCC 49526 / WA1) [Complete proteome] [HAMAP]
Taxonomic identifier565034 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185248

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C0QX38 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: E38F6A1EDC7E5F0D

FASTA55359,991
        10         20         30         40         50         60 
MKTDIEIAQE CKLERIEKIA EKLNLTDDDY EVYGKYKAKI ELSLLNKLKD KKDGKLVLVT 

        70         80         90        100        110        120 
AITPTPAGEG KSTVTIGLTQ GLNKIGKNAV AALREPSLGP VFGIKGGACG GGYSQIVPME 

       130        140        150        160        170        180 
DINLHFNGDF HAISSAHNLI SACIDNHIKQ GNELKIDINK IVFKRVLDMN DRALRDIVIG 

       190        200        210        220        230        240 
LGGSENGVVR QSSFQITVSS EIMAILCLSN SLMDLKEKIG NVIFAYDIND NPLRVKDLKI 

       250        260        270        280        290        300 
EGAACTLLKD AIKPNLVQTL ENTPVIVHGG PFANIAHGCN SILATKMALK LSDYTITEAG 

       310        320        330        340        350        360 
FAADLGAEKF LDIKCRLAGL KPNCIVLVAT IRALKHHGGA SDINKEDIEA LTKGFENLDK 

       370        380        390        400        410        420 
HIENMQKYNV PVVVAINKFV SDTDKEIECI TKHCESKGID ISLCEVWAKG GEGAIELSHK 

       430        440        450        460        470        480 
VLKAASEESN YKPLYELEKS IKEKIETICK EIYSAGEVKF SNKALKMMKK IENMGFGNLP 

       490        500        510        520        530        540 
ICISKTQKSI SDNPALLNAP KGYTLNIDEI KLASGAGFII AMAGGIIDMP GLPKIPVACN 

       550 
IDIDENGKIK GLF 

« Hide

References

[1]"Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49526 / WA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001357 Genomic DNA. Translation: ACN84841.1.
RefSeqYP_002722545.1. NC_012225.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING565034.BHWA1_02387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN84841; ACN84841; BHWA1_02387.
GeneID7667476.
KEGGbhy:BHWA1_02387.
PATRIC21182816. VBIBraHyo62857_2325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycBHYO565034:GJI7-2373-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BRAHW
AccessionPrimary (citable) accession number: C0QX38
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways