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C0QWR3

- SYL_BRAHW

UniProt

C0QWR3 - SYL_BRAHW

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Protein

Leucine--tRNA ligase

Gene
leuS, BHWA1_02260
Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei612 – 6121ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHYO565034:GJI7-2246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BHWA1_02260
OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Taxonomic identifieri565034 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
ProteomesiUP000001803: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Leucine--tRNA ligaseUniRule annotationPRO_1000199183Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi565034.BHWA1_02260.

Structurei

3D structure databases

ProteinModelPortaliC0QWR3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotationAdd
BLAST
Motifi609 – 6135"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QWR3-1 [UniParc]FASTAAdd to Basket

« Hide

MEYNFTTIEK KWQKFWKDNQ SFKTVSKPTD KKYYVLEMFP YPSGKMHMGH    50
VSNYTIADSI ARYYKLLGYD ILHPMGWDAF GMPAENAAIE HKTHPAEWTL 100
KNIANMKDQL NLLGYSYDWD REVTTCLPDY YKWGQWFILK MYEKGLLYRK 150
GGDVNWCDHC NTVLANEQVT PEGTCWRCDG EVTKKKLEQW YIKVTDYAEQ 200
LDADLKLLEG YWPDNVIAMQ KNWIGRSVGA YINFNLDDGK AFPIFTTRPD 250
TIYGVTYMAI AWNYDGLLDM CTTEQKSAVE EFIKKSAKID QKTDYEKEGV 300
FTGRYVVNPF NGEKAPLYAA NFVLAEYGSG AVMAVPAHDQ RDFEFAKKYN 350
IPVKVVIQNA DNSLKAENMT EAYTEDGTVV NSDILNGLSS RDAIKRAIEY 400
ATEKGFGKEK VQYKLRDWLI SRQRYWGNPL PFVHCEKCGV VPVPESELPI 450
TLPMDIEFTV GDNPLKKSES FVNTTCPKCG GKARRETDTM DTFTCSSWYY 500
ARYTDAHNNQ MPFDPSAANA WLGVDQYIGG IEHACMHLLY SRFWYKFMRD 550
IGLVKGDEPF NRLLTQGMVL ANSYESRELK KFYTQEQMNN KEYEKDGIKK 600
EDIIVKMEKM SKSKANGIDP AEIIELFGAD AVRIFVMFVA PPEKDKEWSD 650
EGVKGSSRFL NRIWNLFLKY KDEEAFKNGK SFDYNNLSKE GQKLFRKYNK 700
TIKKVTIDIK DRFHFNTAIA ALMELLNDMS VIKLANNDDY AMFKEVIRGY 750
LILLNPIAPH MTEELYQILN FGKMILEERW VEHDEQYCKD DTFELVFQVN 800
GKIRDRVEAD VNISEDDAKA QALASEKVKA FTDGKNIVKV VYVKGKLVNI 850
VVK 853
Length:853
Mass (Da):98,617
Last modified:May 5, 2009 - v1
Checksum:iDB3FF4804951FD5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84716.1.
RefSeqiWP_012671748.1. NC_012225.1.
YP_002722420.1. NC_012225.1.

Genome annotation databases

EnsemblBacteriaiACN84716; ACN84716; BHWA1_02260.
GeneIDi7667349.
KEGGibhy:BHWA1_02260.
PATRICi21182574. VBIBraHyo62857_2205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001357 Genomic DNA. Translation: ACN84716.1 .
RefSeqi WP_012671748.1. NC_012225.1.
YP_002722420.1. NC_012225.1.

3D structure databases

ProteinModelPortali C0QWR3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 565034.BHWA1_02260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN84716 ; ACN84716 ; BHWA1_02260 .
GeneIDi 7667349.
KEGGi bhy:BHWA1_02260.
PATRICi 21182574. VBIBraHyo62857_2205.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BHYO565034:GJI7-2246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
    Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
    PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49526 / WA1.

Entry informationi

Entry nameiSYL_BRAHW
AccessioniPrimary (citable) accession number: C0QWR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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