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C0QWR3

- SYL_BRAHW

UniProt

C0QWR3 - SYL_BRAHW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei612 – 6121ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBHYO565034:GJI7-2246-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BHWA1_02260
    OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
    Taxonomic identifieri565034 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
    ProteomesiUP000001803: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 853853Leucine--tRNA ligasePRO_1000199183Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi565034.BHWA1_02260.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QWR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi609 – 6135"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QWR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFTTIEK KWQKFWKDNQ SFKTVSKPTD KKYYVLEMFP YPSGKMHMGH    50
    VSNYTIADSI ARYYKLLGYD ILHPMGWDAF GMPAENAAIE HKTHPAEWTL 100
    KNIANMKDQL NLLGYSYDWD REVTTCLPDY YKWGQWFILK MYEKGLLYRK 150
    GGDVNWCDHC NTVLANEQVT PEGTCWRCDG EVTKKKLEQW YIKVTDYAEQ 200
    LDADLKLLEG YWPDNVIAMQ KNWIGRSVGA YINFNLDDGK AFPIFTTRPD 250
    TIYGVTYMAI AWNYDGLLDM CTTEQKSAVE EFIKKSAKID QKTDYEKEGV 300
    FTGRYVVNPF NGEKAPLYAA NFVLAEYGSG AVMAVPAHDQ RDFEFAKKYN 350
    IPVKVVIQNA DNSLKAENMT EAYTEDGTVV NSDILNGLSS RDAIKRAIEY 400
    ATEKGFGKEK VQYKLRDWLI SRQRYWGNPL PFVHCEKCGV VPVPESELPI 450
    TLPMDIEFTV GDNPLKKSES FVNTTCPKCG GKARRETDTM DTFTCSSWYY 500
    ARYTDAHNNQ MPFDPSAANA WLGVDQYIGG IEHACMHLLY SRFWYKFMRD 550
    IGLVKGDEPF NRLLTQGMVL ANSYESRELK KFYTQEQMNN KEYEKDGIKK 600
    EDIIVKMEKM SKSKANGIDP AEIIELFGAD AVRIFVMFVA PPEKDKEWSD 650
    EGVKGSSRFL NRIWNLFLKY KDEEAFKNGK SFDYNNLSKE GQKLFRKYNK 700
    TIKKVTIDIK DRFHFNTAIA ALMELLNDMS VIKLANNDDY AMFKEVIRGY 750
    LILLNPIAPH MTEELYQILN FGKMILEERW VEHDEQYCKD DTFELVFQVN 800
    GKIRDRVEAD VNISEDDAKA QALASEKVKA FTDGKNIVKV VYVKGKLVNI 850
    VVK 853
    Length:853
    Mass (Da):98,617
    Last modified:May 5, 2009 - v1
    Checksum:iDB3FF4804951FD5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN84716.1.
    RefSeqiWP_012671748.1. NC_012225.1.
    YP_002722420.1. NC_012225.1.

    Genome annotation databases

    EnsemblBacteriaiACN84716; ACN84716; BHWA1_02260.
    GeneIDi7667349.
    KEGGibhy:BHWA1_02260.
    PATRICi21182574. VBIBraHyo62857_2205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN84716.1 .
    RefSeqi WP_012671748.1. NC_012225.1.
    YP_002722420.1. NC_012225.1.

    3D structure databases

    ProteinModelPortali C0QWR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 565034.BHWA1_02260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN84716 ; ACN84716 ; BHWA1_02260 .
    GeneIDi 7667349.
    KEGGi bhy:BHWA1_02260.
    PATRICi 21182574. VBIBraHyo62857_2205.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BHYO565034:GJI7-2246-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
      Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
      PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49526 / WA1.

    Entry informationi

    Entry nameiSYL_BRAHW
    AccessioniPrimary (citable) accession number: C0QWR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3