C0QV47 (GPMA_BRAHW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	BHWA1_01885

Organism

Brachyspira hyodysenteriae (strain ATCC 49526 / WA1) [Complete proteome] [HAMAP]

Taxonomic identifier

565034 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Brachyspiraceae › Brachyspira › Treponema hyodysenteriae

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_1000149505
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0QV47 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 40DA5C6D2DF17791	FASTA	248	27,945
	10 20 30 40 50 60 MTKVVLIRHG ESVWNKENLF TGWADVTLSE KGIEEAKAGG AELKKAGFTF DKAYTSTLTR 70 80 90 100 110 120 AIKTLNLVLE EMGLLWIPVD KCWQLNERHY GALQGLNKSQ TAEKYGEDQV KIWRRSYDTP 130 140 150 160 170 180 PPALEKSDER YPGHDPRYKN LSEKELPLTE CLKDTVARVV PFWENVILPD IKAGKKIIIA 190 200 210 220 230 240 AHGNSLRALV KYLDNISDAD ITELNIPTGM PLVYELDDNF KAVNKQYLGD PEAVKKAMEA VANQGKKK

References

[1]

"Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine." Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J. PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49526 / WA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001357 Genomic DNA. Translation: ACN84348.1.
RefSeq	YP_002722052.1. NC_012225.1.
3D structure databases
ProteinModelPortal	C0QV47.
ModBase	Search...
Protein-protein interaction databases
STRING	565034.BHWA1_01885.
Proteomic databases
PRIDE	C0QV47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN84348; ACN84348; BHWA1_01885.
GeneID	7666977.
KEGG	bhy:BHWA1_01885.
PATRIC	21181827. VBIBraHyo62857_1837.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	GQSDWNL.
ProtClustDB	CLSK2810344.
Enzyme and pathway databases
BioCyc	BHYO565034:GJI7-1873-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_BRAHW

Accession

Primary (citable) accession number: C0QV47

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program