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C0QV47

- GPMA_BRAHW

UniProt

C0QV47 - GPMA_BRAHW

Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
    Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
    Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
    Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
    Active sitei182 – 1821UniRule annotation
    Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Enzyme and pathway databases

    BioCyciBHYO565034:GJI7-1873-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
    Short name:
    BPG-dependent PGAMUniRule annotation
    Short name:
    PGAMUniRule annotation
    Short name:
    PhosphoglyceromutaseUniRule annotation
    Short name:
    dPGMUniRule annotation
    Gene namesi
    Name:gpmAUniRule annotation
    Ordered Locus Names:BHWA1_01885
    OrganismiBrachyspira hyodysenteriae (strain ATCC 49526 / WA1)
    Taxonomic identifieri565034 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
    ProteomesiUP000001803: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2482482,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_1000149505Add
    BLAST

    Proteomic databases

    PRIDEiC0QV47.

    Interactioni

    Protein-protein interaction databases

    STRINGi565034.BHWA1_01885.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QV47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
    Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
    Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0588.
    HOGENOMiHOG000221682.
    KOiK01834.
    OMAiIKEWRRS.
    OrthoDBiEOG6C8N1H.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    HAMAPiMF_01039. PGAM_GpmA.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view]
    PANTHERiPTHR11931. PTHR11931. 1 hit.
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    TIGRFAMsiTIGR01258. pgm_1. 1 hit.
    PROSITEiPS00175. PG_MUTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QV47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVVLIRHG ESVWNKENLF TGWADVTLSE KGIEEAKAGG AELKKAGFTF    50
    DKAYTSTLTR AIKTLNLVLE EMGLLWIPVD KCWQLNERHY GALQGLNKSQ 100
    TAEKYGEDQV KIWRRSYDTP PPALEKSDER YPGHDPRYKN LSEKELPLTE 150
    CLKDTVARVV PFWENVILPD IKAGKKIIIA AHGNSLRALV KYLDNISDAD 200
    ITELNIPTGM PLVYELDDNF KAVNKQYLGD PEAVKKAMEA VANQGKKK 248
    Length:248
    Mass (Da):27,945
    Last modified:May 5, 2009 - v1
    Checksum:i40DA5C6D2DF17791
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN84348.1.
    RefSeqiWP_012671388.1. NC_012225.1.
    YP_002722052.1. NC_012225.1.

    Genome annotation databases

    EnsemblBacteriaiACN84348; ACN84348; BHWA1_01885.
    GeneIDi7666977.
    KEGGibhy:BHWA1_01885.
    PATRICi21181827. VBIBraHyo62857_1837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001357 Genomic DNA. Translation: ACN84348.1 .
    RefSeqi WP_012671388.1. NC_012225.1.
    YP_002722052.1. NC_012225.1.

    3D structure databases

    ProteinModelPortali C0QV47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 565034.BHWA1_01885.

    Proteomic databases

    PRIDEi C0QV47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN84348 ; ACN84348 ; BHWA1_01885 .
    GeneIDi 7666977.
    KEGGi bhy:BHWA1_01885.
    PATRICi 21181827. VBIBraHyo62857_1837.

    Phylogenomic databases

    eggNOGi COG0588.
    HOGENOMi HOG000221682.
    KOi K01834.
    OMAi IKEWRRS.
    OrthoDBi EOG6C8N1H.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci BHYO565034:GJI7-1873-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    HAMAPi MF_01039. PGAM_GpmA.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view ]
    PANTHERi PTHR11931. PTHR11931. 1 hit.
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    TIGRFAMsi TIGR01258. pgm_1. 1 hit.
    PROSITEi PS00175. PG_MUTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine."
      Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P., Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
      PLoS ONE 4:E4641-E4641(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49526 / WA1.

    Entry informationi

    Entry nameiGPMA_BRAHW
    AccessioniPrimary (citable) accession number: C0QV47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3