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Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

murF

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 111ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Alternative name(s):
D-alanyl-D-alanine-adding enzymeUniRule annotation
Gene namesi
Name:murFUniRule annotation
Ordered Locus Names:PERMA_0469Imported
OrganismiPersephonella marina (strain DSM 14350 / EX-H1)Imported
Taxonomic identifieri123214 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi123214.PERMA_0469

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 68Mur_ligaseInterPro annotationAdd BLAST40
Domaini103 – 282Mur_ligase_MInterPro annotationAdd BLAST180
Domaini305 – 378Mur_ligase_CInterPro annotationAdd BLAST74

Sequence similaritiesi

Belongs to the MurCDEF family. MurF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EES Bacteria
COG0770 LUCA
HOGENOMiHOG000268119
KOiK01929
OMAiSYNNHWG
OrthoDBiPOG091H00FE

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_02019 MurF, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR035911 MurE/MurF_N
IPR005863 UDP-N-AcMur_synth
PfamiView protein in Pfam
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
SSF63418 SSF63418, 1 hit
TIGRFAMsiTIGR01143 murF, 1 hit

Sequencei

Sequence statusi: Complete.

C0QU93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKEILEIV KGRPLKLRDA DKEIKRFIID SRKAQKDSFF VPLKGSKADG
60 70 80 90 100
HDFIDDALKK GSSGYLTSIE TDYKNGILVD DTLKALTEIG IFKRKKLKKA
110 120 130 140 150
VGITGTSGKT TTKEILRFLL SDIFRVYATE GNYNNEIGLP LTLSNIPENT
160 170 180 190 200
EVGVFELGAS KRGDISKLVS ISKPEVRVLT SVGHGHIEGF GSFEGVVQGK
210 220 230 240 250
GEIFDGGEIS VLPEDLKIYY MDRLKKYVTF GISDYADIKI SEINITPEGT
260 270 280 290 300
AGTVSYKNDK IRITVPVYSR ALFNNIAAAL SVLYALDINP VRSAEKLRDF
310 320 330 340 350
SLPEGRGKVL RKGSLTVIDD SYNANPLSVK NAIETLSGIP SFRVLILGDM
360 370 380 390 400
LELGDLSEQM HIKVGKEILS SDIDLILLYG RETYHTYTVI KDKKNSYHFD
410 420 430 440
DKEKLYRKLM DSIKDKECVL LVKGSRGMRM EDIIEKVLQS
Length:440
Mass (Da):49,066
Last modified:May 5, 2009 - v1
Checksum:i88074B3811C419FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001230 Genomic DNA Translation: ACO04716.1
RefSeqiWP_012676952.1, NC_012440.1

Genome annotation databases

EnsemblBacteriaiACO04716; ACO04716; PERMA_0469
KEGGipmx:PERMA_0469

Entry informationi

Entry nameiC0QU93_PERMH
AccessioniPrimary (citable) accession number: C0QU93
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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