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C0QU93

- C0QU93_PERMH

UniProt

C0QU93 - C0QU93_PERMH

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Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

PERMA_0469

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
  3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR123214:GIZP-467-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Gene namesi
Ordered Locus Names:PERMA_0469Imported
OrganismiPersephonella marina (strain DSM 14350 / EX-H1)Imported
Taxonomic identifieri123214 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
ProteomesiUP000001366: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi123214.PERMA_0469.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0770.
HOGENOMiHOG000268119.
KOiK01929.
OMAiDDTYNAA.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

C0QU93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKEILEIV KGRPLKLRDA DKEIKRFIID SRKAQKDSFF VPLKGSKADG
60 70 80 90 100
HDFIDDALKK GSSGYLTSIE TDYKNGILVD DTLKALTEIG IFKRKKLKKA
110 120 130 140 150
VGITGTSGKT TTKEILRFLL SDIFRVYATE GNYNNEIGLP LTLSNIPENT
160 170 180 190 200
EVGVFELGAS KRGDISKLVS ISKPEVRVLT SVGHGHIEGF GSFEGVVQGK
210 220 230 240 250
GEIFDGGEIS VLPEDLKIYY MDRLKKYVTF GISDYADIKI SEINITPEGT
260 270 280 290 300
AGTVSYKNDK IRITVPVYSR ALFNNIAAAL SVLYALDINP VRSAEKLRDF
310 320 330 340 350
SLPEGRGKVL RKGSLTVIDD SYNANPLSVK NAIETLSGIP SFRVLILGDM
360 370 380 390 400
LELGDLSEQM HIKVGKEILS SDIDLILLYG RETYHTYTVI KDKKNSYHFD
410 420 430 440
DKEKLYRKLM DSIKDKECVL LVKGSRGMRM EDIIEKVLQS
Length:440
Mass (Da):49,066
Last modified:May 5, 2009 - v1
Checksum:i88074B3811C419FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001230 Genomic DNA. Translation: ACO04716.1.
RefSeqiYP_002730258.1. NC_012440.1.

Genome annotation databases

EnsemblBacteriaiACO04716; ACO04716; PERMA_0469.
GeneIDi7675234.
KEGGipmx:PERMA_0469.
PATRICi22914409. VBIPerMar119911_0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001230 Genomic DNA. Translation: ACO04716.1 .
RefSeqi YP_002730258.1. NC_012440.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 123214.PERMA_0469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO04716 ; ACO04716 ; PERMA_0469 .
GeneIDi 7675234.
KEGGi pmx:PERMA_0469.
PATRICi 22914409. VBIPerMar119911_0515.

Phylogenomic databases

eggNOGi COG0770.
HOGENOMi HOG000268119.
KOi K01929.
OMAi DDTYNAA.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci PMAR123214:GIZP-467-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view ]
PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01143. murF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14350 / EX-H1Imported.

Entry informationi

Entry nameiC0QU93_PERMH
AccessioniPrimary (citable) accession number: C0QU93
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3