Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C0QU93

- C0QU93_PERMH

UniProt

C0QU93 - C0QU93_PERMH

Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

PERMA_0469

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
    3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR123214:GIZP-467-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
    Gene namesi
    Ordered Locus Names:PERMA_0469Imported
    OrganismiPersephonella marina (strain DSM 14350 / EX-H1)Imported
    Taxonomic identifieri123214 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
    ProteomesiUP000001366: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Interactioni

    Protein-protein interaction databases

    STRINGi123214.PERMA_0469.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0770.
    HOGENOMiHOG000268119.
    KOiK01929.
    OMAiDDTYNAA.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view]
    PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsiTIGR01143. murF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0QU93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKEILEIV KGRPLKLRDA DKEIKRFIID SRKAQKDSFF VPLKGSKADG    50
    HDFIDDALKK GSSGYLTSIE TDYKNGILVD DTLKALTEIG IFKRKKLKKA 100
    VGITGTSGKT TTKEILRFLL SDIFRVYATE GNYNNEIGLP LTLSNIPENT 150
    EVGVFELGAS KRGDISKLVS ISKPEVRVLT SVGHGHIEGF GSFEGVVQGK 200
    GEIFDGGEIS VLPEDLKIYY MDRLKKYVTF GISDYADIKI SEINITPEGT 250
    AGTVSYKNDK IRITVPVYSR ALFNNIAAAL SVLYALDINP VRSAEKLRDF 300
    SLPEGRGKVL RKGSLTVIDD SYNANPLSVK NAIETLSGIP SFRVLILGDM 350
    LELGDLSEQM HIKVGKEILS SDIDLILLYG RETYHTYTVI KDKKNSYHFD 400
    DKEKLYRKLM DSIKDKECVL LVKGSRGMRM EDIIEKVLQS 440
    Length:440
    Mass (Da):49,066
    Last modified:May 5, 2009 - v1
    Checksum:i88074B3811C419FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO04716.1.
    RefSeqiYP_002730258.1. NC_012440.1.

    Genome annotation databases

    EnsemblBacteriaiACO04716; ACO04716; PERMA_0469.
    GeneIDi7675234.
    KEGGipmx:PERMA_0469.
    PATRICi22914409. VBIPerMar119911_0515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO04716.1 .
    RefSeqi YP_002730258.1. NC_012440.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 123214.PERMA_0469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO04716 ; ACO04716 ; PERMA_0469 .
    GeneIDi 7675234.
    KEGGi pmx:PERMA_0469.
    PATRICi 22914409. VBIPerMar119911_0515.

    Phylogenomic databases

    eggNOGi COG0770.
    HOGENOMi HOG000268119.
    KOi K01929.
    OMAi DDTYNAA.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci PMAR123214:GIZP-467-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view ]
    PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsi TIGR01143. murF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14350 / EX-H1Imported.

    Entry informationi

    Entry nameiC0QU93_PERMH
    AccessioniPrimary (citable) accession number: C0QU93
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3