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C0QU93 (C0QU93_PERMH) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136

EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:PERMA_0469 EMBL ACO04716.1
OrganismPersephonella marina (strain DSM 14350 / EX-H1) [Complete proteome] [HAMAP] EMBL ACO04716.1
Taxonomic identifier123214 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136

Subcellular location

Cytoplasm By similarity RuleBase RU004136.

Sequence similarities

Belongs to the MurCDEF family.

Sequences

Sequence LengthMass (Da)Tools
C0QU93 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 88074B3811C419FB

FASTA44049,066
        10         20         30         40         50         60 
MKIKEILEIV KGRPLKLRDA DKEIKRFIID SRKAQKDSFF VPLKGSKADG HDFIDDALKK 

        70         80         90        100        110        120 
GSSGYLTSIE TDYKNGILVD DTLKALTEIG IFKRKKLKKA VGITGTSGKT TTKEILRFLL 

       130        140        150        160        170        180 
SDIFRVYATE GNYNNEIGLP LTLSNIPENT EVGVFELGAS KRGDISKLVS ISKPEVRVLT 

       190        200        210        220        230        240 
SVGHGHIEGF GSFEGVVQGK GEIFDGGEIS VLPEDLKIYY MDRLKKYVTF GISDYADIKI 

       250        260        270        280        290        300 
SEINITPEGT AGTVSYKNDK IRITVPVYSR ALFNNIAAAL SVLYALDINP VRSAEKLRDF 

       310        320        330        340        350        360 
SLPEGRGKVL RKGSLTVIDD SYNANPLSVK NAIETLSGIP SFRVLILGDM LELGDLSEQM 

       370        380        390        400        410        420 
HIKVGKEILS SDIDLILLYG RETYHTYTVI KDKKNSYHFD DKEKLYRKLM DSIKDKECVL 

       430        440 
LVKGSRGMRM EDIIEKVLQS 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14350 / EX-H1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001230 Genomic DNA. Translation: ACO04716.1.
RefSeqYP_002730258.1. NC_012440.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING123214.PERMA_0469.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO04716; ACO04716; PERMA_0469.
GeneID7675234.
KEGGpmx:PERMA_0469.
PATRIC22914409. VBIPerMar119911_0515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268119.
KOK01929.
OMARTWEVAD.
OrthoDBEOG6PKFCR.
ProtClustDBCLSK2479343.

Enzyme and pathway databases

BioCycPMAR123214:GIZP-467-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0QU93_PERMH
AccessionPrimary (citable) accession number: C0QU93
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)