C0QU93 (C0QU93_PERMH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136

Gene names

Ordered Locus Names:

PERMA_0469 EMBL ACO04716.1

Organism

Persephonella marina (strain DSM 14350 / EX-H1) [Complete proteome] [HAMAP] EMBL ACO04716.1

Taxonomic identifier

123214 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Hydrogenothermaceae › Persephonella › Persephonella marina

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MurCDEF family. RuleBase RU003630

Ontologies

Keywords
Biological process	Cell cycle Cell division RuleBase RU004136 Cell shape Cell wall biogenesis/degradation RuleBase RU004136 Peptidoglycan synthesis RuleBase RU004136
Ligand	ATP-binding RuleBase RU003630 Nucleotide-binding
Molecular function	Ligase RuleBase RU003630
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: EC UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C0QU93 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 88074B3811C419FB	FASTA	440	49,066
	10 20 30 40 50 60 MKIKEILEIV KGRPLKLRDA DKEIKRFIID SRKAQKDSFF VPLKGSKADG HDFIDDALKK 70 80 90 100 110 120 GSSGYLTSIE TDYKNGILVD DTLKALTEIG IFKRKKLKKA VGITGTSGKT TTKEILRFLL 130 140 150 160 170 180 SDIFRVYATE GNYNNEIGLP LTLSNIPENT EVGVFELGAS KRGDISKLVS ISKPEVRVLT 190 200 210 220 230 240 SVGHGHIEGF GSFEGVVQGK GEIFDGGEIS VLPEDLKIYY MDRLKKYVTF GISDYADIKI 250 260 270 280 290 300 SEINITPEGT AGTVSYKNDK IRITVPVYSR ALFNNIAAAL SVLYALDINP VRSAEKLRDF 310 320 330 340 350 360 SLPEGRGKVL RKGSLTVIDD SYNANPLSVK NAIETLSGIP SFRVLILGDM LELGDLSEQM 370 380 390 400 410 420 HIKVGKEILS SDIDLILLYG RETYHTYTVI KDKKNSYHFD DKEKLYRKLM DSIKDKECVL 430 440 LVKGSRGMRM EDIIEKVLQS

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14350 / EX-H1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001230 Genomic DNA. Translation: ACO04716.1.
RefSeq	YP_002730258.1. NC_012440.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	123214.PERMA_0469.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO04716; ACO04716; PERMA_0469.
GeneID	7675234.
KEGG	pmx:PERMA_0469.
PATRIC	22914409. VBIPerMar119911_0515.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0770.
HOGENOM	HOG000268119.
KO	K01929.
OMA	GNRNNEI.
ProtClustDB	CLSK2479343.
Enzyme and pathway databases
BioCyc	PMAR123214:GIZP-467-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.1190.10. 1 hit. 3.90.190.20. 1 hit.
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-pentapeptide_synth. [Graphical view]
PANTHER	PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01143. murF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C0QU93_PERMH

Accession

Primary (citable) accession number: C0QU93

Entry history

Integrated into UniProtKB/TrEMBL:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)