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C0QU08 (UPPP_PERMH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:PERMA_0381
OrganismPersephonella marina (strain DSM 14350 / EX-H1) [Complete proteome] [HAMAP]
Taxonomic identifier123214 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148822

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane234 – 25421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C0QU08 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 8426C3D670427E16

FASTA25428,358
        10         20         30         40         50         60 
MGIIESIILG IVEGLTEFLP VSSTGHLILV SKLLGLEQTD AHKAFEVAIQ SGAILAVVFL 

        70         80         90        100        110        120 
YREKLTHSID LWKRLIIAFI PTGILGFLLY KIIKGLFSPY IVSIMLIVGG LVFIAVEFFY 

       130        140        150        160        170        180 
KKSEHQIDDI LKIPYYKAFF IGVFQSIAMI PGTSRSGATI IGGLLLGLDR KTAAEFSFLL 

       190        200        210        220        230        240 
AVPTMFAATS YDIMKNYHHF HIENWIALLT GFVTAFVFAV LAIKLFIGFV SRYNFVPFGI 

       250 
YRIILGFIFL LFVL 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14350 / EX-H1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001230 Genomic DNA. Translation: ACO04552.1.
RefSeqYP_002730173.1. NC_012440.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING123214.PERMA_0381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO04552; ACO04552; PERMA_0381.
GeneID7674625.
KEGGpmx:PERMA_0381.
PATRIC22914237. VBIPerMar119911_0431.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2479738.

Enzyme and pathway databases

BioCycPMAR123214:GIZP-380-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PERMH
AccessionPrimary (citable) accession number: C0QU08
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families