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Protein

Probable DNA ligase

Gene

lig

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei339ATPUniRule annotation1
Binding sitei416ATPUniRule annotation1
Binding sitei422ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PERMA_1901
OrganismiPersephonella marina (strain DSM 14350 / EX-H1)
Taxonomic identifieri123214 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
Proteomesi
  • UP000001366 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001347301 – 582Probable DNA ligaseAdd BLAST582

Proteomic databases

PRIDEiC0QSL7

Interactioni

Protein-protein interaction databases

STRINGi123214.PERMA_1901

Structurei

3D structure databases

ProteinModelPortaliC0QSL7
SMRiC0QSL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TRG Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG091H09SJ

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C0QSL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYTKLAQLY QILEETTSRI KMTQALVDLF KETPPELIDK VVYLSIGRIA
60 70 80 90 100
PEYTGLDYNF SEKSAIKALS TVLNISEHDI QHQVLQTGDL GDAGKKLYEE
110 120 130 140 150
KGVKPEGILT VEEVYRTLRE IAQTTGYGST KKKLQLFTEL LKKASPLEVK
160 170 180 190 200
YLLRTITERL RLGIGDNTIM DALSIAFTGK KENREIIERA YNISSDLGYV
210 220 230 240 250
ARILAEKGLD AVKNIKIEIG RPIRPMLAER MAIPSYILKK LGGKAGAEYK
260 270 280 290 300
YDGERIQVHR KGDTFYLFSR RLENITDQFP DLIEFLKESI PEECIIELEA
310 320 330 340 350
VVIDPSSGAI RPFQDLMNRR VKYVTRFHIM MYPIAGFIFD IMYLNGEDLT
360 370 380 390 400
LKPYPERRKI LEENIKITER INLSERKIVD NVEDLESFFH QAIEDGCEGL
410 420 430 440 450
VCKSLQKDSI YQAGKRGFLW IKYKRDYKSH LADTLDLVVV GAFYGKGART
460 470 480 490 500
GYFGSLLMAC YDPETDQFKT VCKVGTGFKE DDFKKLDDLL KEHTLDHKHP
510 520 530 540 550
RVNSILSADI WYEPFLVLEI TGAELTLSPV HTCGWDRIKI NRGLGLRFPR
560 570 580
FTGRYRFDKR PEDATTEEEI INMYKNQIQI KS
Length:582
Mass (Da):66,893
Last modified:May 5, 2009 - v1
Checksum:i86B7BDB3B593C637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001230 Genomic DNA Translation: ACO03229.1
RefSeqiWP_012675468.1, NC_012440.1

Genome annotation databases

EnsemblBacteriaiACO03229; ACO03229; PERMA_1901
KEGGipmx:PERMA_1901

Similar proteinsi

Entry informationi

Entry nameiDNLI_PERMH
AccessioniPrimary (citable) accession number: C0QSL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health