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C0QSL7

- DNLI_PERMH

UniProt

C0QSL7 - DNLI_PERMH

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Protein
Probable DNA ligase
Gene
lig, PERMA_1901
Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarity
Active sitei250 – 2501N6-AMP-lysine intermediate By similarity
Binding sitei255 – 2551ATP By similarity
Binding sitei270 – 2701ATP By similarity
Binding sitei299 – 2991ATP By similarity
Binding sitei339 – 3391ATP By similarity
Binding sitei416 – 4161ATP By similarity
Binding sitei422 – 4221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR123214:GIZP-1899-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:PERMA_1901
OrganismiPersephonella marina (strain DSM 14350 / EX-H1)
Taxonomic identifieri123214 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
ProteomesiUP000001366: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Probable DNA ligaseUniRule annotation
PRO_1000134730Add
BLAST

Proteomic databases

PRIDEiC0QSL7.

Interactioni

Protein-protein interaction databases

STRINGi123214.PERMA_1901.

Structurei

3D structure databases

ProteinModelPortaliC0QSL7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiLDPSGYN.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QSL7-1 [UniParc]FASTAAdd to Basket

« Hide

MEYTKLAQLY QILEETTSRI KMTQALVDLF KETPPELIDK VVYLSIGRIA    50
PEYTGLDYNF SEKSAIKALS TVLNISEHDI QHQVLQTGDL GDAGKKLYEE 100
KGVKPEGILT VEEVYRTLRE IAQTTGYGST KKKLQLFTEL LKKASPLEVK 150
YLLRTITERL RLGIGDNTIM DALSIAFTGK KENREIIERA YNISSDLGYV 200
ARILAEKGLD AVKNIKIEIG RPIRPMLAER MAIPSYILKK LGGKAGAEYK 250
YDGERIQVHR KGDTFYLFSR RLENITDQFP DLIEFLKESI PEECIIELEA 300
VVIDPSSGAI RPFQDLMNRR VKYVTRFHIM MYPIAGFIFD IMYLNGEDLT 350
LKPYPERRKI LEENIKITER INLSERKIVD NVEDLESFFH QAIEDGCEGL 400
VCKSLQKDSI YQAGKRGFLW IKYKRDYKSH LADTLDLVVV GAFYGKGART 450
GYFGSLLMAC YDPETDQFKT VCKVGTGFKE DDFKKLDDLL KEHTLDHKHP 500
RVNSILSADI WYEPFLVLEI TGAELTLSPV HTCGWDRIKI NRGLGLRFPR 550
FTGRYRFDKR PEDATTEEEI INMYKNQIQI KS 582
Length:582
Mass (Da):66,893
Last modified:May 5, 2009 - v1
Checksum:i86B7BDB3B593C637
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001230 Genomic DNA. Translation: ACO03229.1.
RefSeqiYP_002731663.1. NC_012440.1.

Genome annotation databases

EnsemblBacteriaiACO03229; ACO03229; PERMA_1901.
GeneIDi7674871.
KEGGipmx:PERMA_1901.
PATRICi22917239. VBIPerMar119911_1903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001230 Genomic DNA. Translation: ACO03229.1 .
RefSeqi YP_002731663.1. NC_012440.1.

3D structure databases

ProteinModelPortali C0QSL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 123214.PERMA_1901.

Proteomic databases

PRIDEi C0QSL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO03229 ; ACO03229 ; PERMA_1901 .
GeneIDi 7674871.
KEGGi pmx:PERMA_1901.
PATRICi 22917239. VBIPerMar119911_1903.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi LDPSGYN.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci PMAR123214:GIZP-1899-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14350 / EX-H1.

Entry informationi

Entry nameiDNLI_PERMH
AccessioniPrimary (citable) accession number: C0QSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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