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C0QSL7

- DNLI_PERMH

UniProt

C0QSL7 - DNLI_PERMH

Protein

Probable DNA ligase

Gene

lig

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPUniRule annotation
    Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
    Binding sitei255 – 2551ATPUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei339 – 3391ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation
    Binding sitei422 – 4221ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR123214:GIZP-1899-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:PERMA_1901
    OrganismiPersephonella marina (strain DSM 14350 / EX-H1)
    Taxonomic identifieri123214 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
    ProteomesiUP000001366: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Probable DNA ligasePRO_1000134730Add
    BLAST

    Proteomic databases

    PRIDEiC0QSL7.

    Interactioni

    Protein-protein interaction databases

    STRINGi123214.PERMA_1901.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QSL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiLDPSGYN.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QSL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYTKLAQLY QILEETTSRI KMTQALVDLF KETPPELIDK VVYLSIGRIA    50
    PEYTGLDYNF SEKSAIKALS TVLNISEHDI QHQVLQTGDL GDAGKKLYEE 100
    KGVKPEGILT VEEVYRTLRE IAQTTGYGST KKKLQLFTEL LKKASPLEVK 150
    YLLRTITERL RLGIGDNTIM DALSIAFTGK KENREIIERA YNISSDLGYV 200
    ARILAEKGLD AVKNIKIEIG RPIRPMLAER MAIPSYILKK LGGKAGAEYK 250
    YDGERIQVHR KGDTFYLFSR RLENITDQFP DLIEFLKESI PEECIIELEA 300
    VVIDPSSGAI RPFQDLMNRR VKYVTRFHIM MYPIAGFIFD IMYLNGEDLT 350
    LKPYPERRKI LEENIKITER INLSERKIVD NVEDLESFFH QAIEDGCEGL 400
    VCKSLQKDSI YQAGKRGFLW IKYKRDYKSH LADTLDLVVV GAFYGKGART 450
    GYFGSLLMAC YDPETDQFKT VCKVGTGFKE DDFKKLDDLL KEHTLDHKHP 500
    RVNSILSADI WYEPFLVLEI TGAELTLSPV HTCGWDRIKI NRGLGLRFPR 550
    FTGRYRFDKR PEDATTEEEI INMYKNQIQI KS 582
    Length:582
    Mass (Da):66,893
    Last modified:May 5, 2009 - v1
    Checksum:i86B7BDB3B593C637
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO03229.1.
    RefSeqiYP_002731663.1. NC_012440.1.

    Genome annotation databases

    EnsemblBacteriaiACO03229; ACO03229; PERMA_1901.
    GeneIDi7674871.
    KEGGipmx:PERMA_1901.
    PATRICi22917239. VBIPerMar119911_1903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO03229.1 .
    RefSeqi YP_002731663.1. NC_012440.1.

    3D structure databases

    ProteinModelPortali C0QSL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 123214.PERMA_1901.

    Proteomic databases

    PRIDEi C0QSL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO03229 ; ACO03229 ; PERMA_1901 .
    GeneIDi 7674871.
    KEGGi pmx:PERMA_1901.
    PATRICi 22917239. VBIPerMar119911_1903.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi LDPSGYN.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci PMAR123214:GIZP-1899-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14350 / EX-H1.

    Entry informationi

    Entry nameiDNLI_PERMH
    AccessioniPrimary (citable) accession number: C0QSL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3