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C0QSL7 (DNLI_PERMH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:PERMA_1901
OrganismPersephonella marina (strain DSM 14350 / EX-H1) [Complete proteome] [HAMAP]
Taxonomic identifier123214 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Probable DNA ligase HAMAP-Rule MF_00407
PRO_1000134730

Sites

Active site2501N6-AMP-lysine intermediate By similarity
Binding site2481ATP By similarity
Binding site2551ATP By similarity
Binding site2701ATP By similarity
Binding site2991ATP By similarity
Binding site3391ATP By similarity
Binding site4161ATP By similarity
Binding site4221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C0QSL7 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 86B7BDB3B593C637

FASTA58266,893
        10         20         30         40         50         60 
MEYTKLAQLY QILEETTSRI KMTQALVDLF KETPPELIDK VVYLSIGRIA PEYTGLDYNF 

        70         80         90        100        110        120 
SEKSAIKALS TVLNISEHDI QHQVLQTGDL GDAGKKLYEE KGVKPEGILT VEEVYRTLRE 

       130        140        150        160        170        180 
IAQTTGYGST KKKLQLFTEL LKKASPLEVK YLLRTITERL RLGIGDNTIM DALSIAFTGK 

       190        200        210        220        230        240 
KENREIIERA YNISSDLGYV ARILAEKGLD AVKNIKIEIG RPIRPMLAER MAIPSYILKK 

       250        260        270        280        290        300 
LGGKAGAEYK YDGERIQVHR KGDTFYLFSR RLENITDQFP DLIEFLKESI PEECIIELEA 

       310        320        330        340        350        360 
VVIDPSSGAI RPFQDLMNRR VKYVTRFHIM MYPIAGFIFD IMYLNGEDLT LKPYPERRKI 

       370        380        390        400        410        420 
LEENIKITER INLSERKIVD NVEDLESFFH QAIEDGCEGL VCKSLQKDSI YQAGKRGFLW 

       430        440        450        460        470        480 
IKYKRDYKSH LADTLDLVVV GAFYGKGART GYFGSLLMAC YDPETDQFKT VCKVGTGFKE 

       490        500        510        520        530        540 
DDFKKLDDLL KEHTLDHKHP RVNSILSADI WYEPFLVLEI TGAELTLSPV HTCGWDRIKI 

       550        560        570        580 
NRGLGLRFPR FTGRYRFDKR PEDATTEEEI INMYKNQIQI KS 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14350 / EX-H1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001230 Genomic DNA. Translation: ACO03229.1.
RefSeqYP_002731663.1. NC_012440.1.

3D structure databases

ProteinModelPortalC0QSL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING123214.PERMA_1901.

Proteomic databases

PRIDEC0QSL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO03229; ACO03229; PERMA_1901.
GeneID7674871.
KEGGpmx:PERMA_1901.
PATRIC22917239. VBIPerMar119911_1903.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
OrthoDBEOG6Q8HXT.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycPMAR123214:GIZP-1899-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_PERMH
AccessionPrimary (citable) accession number: C0QSL7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families