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C0QS07 (C0QS07_PERMH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172 EMBL ACO04414.1
Ordered Locus Names:PERMA_1689
OrganismPersephonella marina (strain DSM 14350 / EX-H1) [Complete proteome] [HAMAP]
Taxonomic identifier123214 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Hydrogenothermaceae › Persephonella

Protein attributes

Sequence length768 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6491Zinc By similarity HAMAP MF_00172
Metal binding6511Zinc By similarity HAMAP MF_00172
Metal binding7341Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
C0QS07 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 33E7302E5FAFC40F

FASTA76889,377
        10         20         30         40         50         60 
MGIKTTAFGF PKIGKNRELK KYVEGYWKGE INKDEMYRGL EKVNEERFEF LKKGDLDLVP 

        70         80         90        100        110        120 
SNDFSVYDFI LDISTMIDII PDRFRNIQDD TDRYFAMARG SESAIACEMT KWFDTNYHYI 

       130        140        150        160        170        180 
VPELTGNFRL IKNRPLDSYR WAKERGIETK PVIVGPFTYV YLGKVYERQE GSLLMNMIRS 

       190        200        210        220        230        240 
YDSEKFRPMV LSLAKVYNEI LKELQSEGVK AVQLDEPALV LDITDQDVDT LLEAYRILTD 

       250        260        270        280        290        300 
GIDKTEIHLH TYYESLDNFE KIVFSLPVTG IGLDFVVNDE NLENLKRYGF PDDKKLIAGV 

       310        320        330        340        350        360 
ISGRDPWKTD YRKVLDQLET IGRHVSEDRL IISNGSPLFH LPVTIESEKG FLDENLLKML 

       370        380        390        400        410        420 
SFASERIDEL RILKEIINEG KEVPDQNIEE IRSIFINEDV KRSVKEIESI EIRRKDDFRE 

       430        440        450        460        470        480 
RYRSQMELLG LPKFPTTTIG SFPQTKEVRQ VRAKFRRGEI TEAEYESFIK DQIKKAVEIQ 

       490        500        510        520        530        540 
EEIGLDVFVH GEFERTDMVE FFGEKMEGFA FTKNGWVQSY GTRCVRPPII YGDVSRPESM 

       550        560        570        580        590        600 
TVKEIVYAQS LTNKPVKGML TGPVTILNWS FYRKDIPKKE IAFQIALALK EEVLDLEKAG 

       610        620        630        640        650        660 
IKIIQIDEPA FREGLPLKKR KQEDYLRWAV KAFRLTNHTV KKTTQIHTHM CYSEFNEIIE 

       670        680        690        700        710        720 
WIYQMDADVI SIEASRSKGE IIQAFEDFNY DHGIGIGLYD IHSPRIPSVE EMLEIAERTV 

       730        740        750        760 
KVTDKNLIWI NPDCGLKTRD WKETIPALKN MVKVAQILRD KYGKELEL

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References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001230 Genomic DNA. Translation: ACO04414.1.
RefSeqYP_002731453.1. NC_012440.1.

3D structure databases

ProteinModelPortalC0QS07.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0QS07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7674962.
GenomeReviewsGene locus PERMA_1689 in contig CP001230_GR.
KEGGpmx:PERMA_1689.
PATRIC22916827. VBIPerMar119911_1699.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0QS07_PERMH
AccessionPrimary (citable) accession number: C0QS07
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info