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C0QR27

- LPXB_PERMH

UniProt

C0QR27 - LPXB_PERMH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Persephonella marina (strain DSM 14350 / EX-H1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPMAR123214:GIZP-1353-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PERMA_1354
    OrganismiPersephonella marina (strain DSM 14350 / EX-H1)
    Taxonomic identifieri123214 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
    ProteomesiUP000001366: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Lipid-A-disaccharide synthasePRO_1000191488Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi123214.PERMA_1354.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QR27.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0QR27-1 [UniParc]FASTAAdd to Basket

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    MKKAFISVGE ISGDNYASQL VKALPDFMWV GITGPKMREA GVETVEKLEN    50
    ISVVGLMEAL PKYFKIKETF KRSVEILDKG IDLLVVVDFP GFNLKLLKEA 100
    KKRGIKTVYF IAPQVWAWGK GRIPKIAQYT DLLIAIWPFE KEIYTDYISD 150
    SFRVEYVGHP ILDIIKTEET EESFKEKIGI EKDKKIFGLL PGSRESEVKT 200
    LLPILLSSAE IIYRKREDLH FVIPSTPNME ENVKQIAGSK KVPLSVITVK 250
    DFRHPSYEVM KHSVFLNVAS GTATLETAIF GNPFLLVYKV SPVTFFIGKM 300
    LVSIDYLGLP NIIAGREIIK ELLQKECNPE SIARWSLRYL EDPEVYERTK 350
    NDLEKVKKAL GEKGAIKRSA DLIKELSLS 379
    Length:379
    Mass (Da):42,965
    Last modified:May 5, 2009 - v1
    Checksum:i185E5B6D6CE3335D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO03161.1.
    RefSeqiYP_002731123.1. NC_012440.1.

    Genome annotation databases

    EnsemblBacteriaiACO03161; ACO03161; PERMA_1354.
    GeneIDi7675239.
    KEGGipmx:PERMA_1354.
    PATRICi22916165. VBIPerMar119911_1372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001230 Genomic DNA. Translation: ACO03161.1 .
    RefSeqi YP_002731123.1. NC_012440.1.

    3D structure databases

    ProteinModelPortali C0QR27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 123214.PERMA_1354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO03161 ; ACO03161 ; PERMA_1354 .
    GeneIDi 7675239.
    KEGGi pmx:PERMA_1354.
    PATRICi 22916165. VBIPerMar119911_1372.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PMAR123214:GIZP-1353-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14350 / EX-H1.

    Entry informationi

    Entry nameiLPXB_PERMH
    AccessioniPrimary (citable) accession number: C0QR27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3