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C0QLF1

- PROA_DESAH

UniProt

C0QLF1 - PROA_DESAH

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Protein
Gamma-glutamyl phosphate reductase
Gene
proA, HRM2_31740
Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-3172-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductase (EC:1.2.1.41)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name:
GSA dehydrogenase
Gene namesi
Name:proA
Ordered Locus Names:HRM2_31740
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Gamma-glutamyl phosphate reductaseUniRule annotation
PRO_1000205992Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_31740.

Structurei

3D structure databases

ProteinModelPortaliC0QLF1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiRATEDIF.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QLF1-1 [UniParc]FASTAAdd to Basket

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MTLASMIEDI ARRARTAARP LATASADTKN TVLAEIARGL AHGKREIEAE    50
NQKDLKAARD SGMSAAMIDR LTISDQTLES MIKGLNQVIA LPDPVGRITG 100
AWTRPNGLEI SKRRIPLGVI AMIYESRPNV TVDAAALCLK AGNAAILRGG 150
SEAFFSNTIL ARIIGNALET VGISRDSVQV LPVKDRQAIT ELLQQEAYID 200
LVIPRGGESL IRFVVKHSTI PVLKHYKGVC HVYVDETCNM DEAVDICINA 250
KTQRPGVCNA METLLVHERI APLFLPRMAQ AFSAAKVEMR GCPATLAMVP 300
QALPADETDW STEYLDLIVS VKIVKDLAQA MAHIAVFGSD HTDVIVTDIP 350
ENAETFINTV SSSMVGVNVS TRFNDGGELG LGAEIGISTS RLHAFGPMGL 400
EELTSTKFVV VGKGQTRQ 418
Length:418
Mass (Da):45,025
Last modified:May 5, 2009 - v1
Checksum:i51CDA5FDD7AC0651
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN16255.1.
RefSeqiYP_002604419.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN16255; ACN16255; HRM2_31740.
GeneIDi7502638.
KEGGidat:HRM2_31740.
PATRICi21686057. VBIDesAut25181_3280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN16255.1 .
RefSeqi YP_002604419.1. NC_012108.1.

3D structure databases

ProteinModelPortali C0QLF1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 177437.HRM2_31740.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN16255 ; ACN16255 ; HRM2_31740 .
GeneIDi 7502638.
KEGGi dat:HRM2_31740.
PATRICi 21686057. VBIDesAut25181_3280.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi RATEDIF.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci DAUT177437:GHLR-3172-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2.

Entry informationi

Entry nameiPROA_DESAH
AccessioniPrimary (citable) accession number: C0QLF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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