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C0QKZ8 (SYR_DESAH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:HRM2_31550
OrganismDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) [Complete proteome] [HAMAP]
Taxonomic identifier177437 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000203090

Regions

Motif128 – 13811"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
C0QKZ8 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: B951095CC522A032

FASTA55561,868
        10         20         30         40         50         60 
MKESIKQLIL GGARRAFDKG LLKSDEFPGM EIEAPRHEAH GDFSTNFAMV SAATQKMAPR 

        70         80         90        100        110        120 
KIAEAVISCM DSDSVIEKTE IAGPGFINFF LANRAWYPTL DRIVKEDDRF GSSDFGAGKK 

       130        140        150        160        170        180 
VQVEFVSANP TGPLHVGHAR GAAVGDAVAN ILSFAGFDVQ REYYINDSGR QIRTLGLSVW 

       190        200        210        220        230        240 
LRLCQQLGRE VEFPTDCYQG DYIKEIAADL HGKMGRELSE KDEAEAVSIC AKFAAQVILS 

       250        260        270        280        290        300 
GIRADLVAFG VEYDQWFSEE SLYASGRVQK AIEEFKARDV IYEKDGAQWF RTERYGDEKD 

       310        320        330        340        350        360 
RVVVRNNGIT TYFASDIAYH MEKFDRGFDR VIDVWGADHH GYINRINAAI DASGRQSDQF 

       370        380        390        400        410        420 
DVILVQLVNL LRNGQPVAMS SRSGEFVTLK DIVDEVGKDA ARFLFLSRSY DSGLDFDLEV 

       430        440        450        460        470        480 
AKQKTSDNPV YYVQYVHARI AGILMKAVSE KVLNEAEKPG AGNRELLVEP EEINLLKILA 

       490        500        510        520        530        540 
AFPETVEKSA ATLHPHVIFT YLMGLASAFH GYYNRHKVIT PDRELSRGRI SLVFAVKTVI 

       550 
RNGLNLLGVS APERM 

« Hide

References

[1]"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide."
Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R.
Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001087 Genomic DNA. Translation: ACN16238.1.
RefSeqYP_002604402.1. NC_012108.1.

3D structure databases

ProteinModelPortalC0QKZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177437.HRM2_31550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN16238; ACN16238; HRM2_31550.
GeneID7502619.
KEGGdat:HRM2_31550.
PATRIC21686021. VBIDesAut25181_3264.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAPRVKGAI.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycDAUT177437:GHLR-3153-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_DESAH
AccessionPrimary (citable) accession number: C0QKZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries