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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei621ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDAUT177437:G1GC3-2703-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HRM2_27190
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
Proteomesi
  • UP000000442 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002022171 – 863Leucine--tRNA ligaseAdd BLAST863

Proteomic databases

PRIDEiC0QI75

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_27190

Structurei

3D structure databases

ProteinModelPortaliC0QI75
SMRiC0QI75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi618 – 622"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C0QI75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERYNPEKV EPLWQAYWNQ HQTFKATEDG SKPKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYTIGD VVVRYKRMKG FNVLHPMGWD AFGMPAENAA IDNNTHPAAW
110 120 130 140 150
TYENIRTMRR QLKRMGFSYD WDREIATCRP EYYRWEQWLF LKMLDKDMVY
160 170 180 190 200
RKESYVNWCD HCQTVLANEQ VEQDMCWRCG KPVQQKKLWQ WFFRITDFAE
210 220 230 240 250
DLLVHCDKLP GWPDNVTLMQ KNWIGKSQGS EIRFPIQGID ENIPVFTTRP
260 270 280 290 300
DTLFGSTFMC LAPEHPLVET LSRGTDQAAA VTEFTTRVLN QERSSIALEK
310 320 330 340 350
YEKEGVFTGA WCINPVTREK MPIYTANFAL MEYGTGAVMS VPAHDQRDFD
360 370 380 390 400
FARKYGLPIK VVIQPPGEPL DPATMIEAYT GQGTLADSGE FSGLGNLEAM
410 420 430 440 450
GAITRWLENK GLGKTTVSFR LRDWGISRQR YWGTPIPVIH CPDCGIVPVK
460 470 480 490 500
EETLPVVLPE DAALLDNGGS PLATLDGFAR VNCPVCNRAD ARRETDTMDT
510 520 530 540 550
FVESSWYFAR YCSPRYDKGM FDPAAVAYWM PVDQYIGGVE HAILHLLYSR
560 570 580 590 600
YFMRVLNTLG LIDFKEPFER LLTQGMVCKE TLTCPEHGFI YPDDAETVND
610 620 630 640 650
KVICKRCNSD VEVGRVIKMS KSKKNVIDPN ALLDQYGADI TRLFCLFAAP
660 670 680 690 700
PEKDLEWNDD GVEGCNRFIN RVWRLADRCK STYIDLLPYS GVVADLKGEP
710 720 730 740 750
KKLFIKANQT IKKVTDDIEE SFHFNTAISA VMELVNAMYS ADLDPDQTDM
760 770 780 790 800
GEVALFCIEN IVLLLSPIVP HFCEELWSIL GHGPSIVDQP WPDYQKDALL
810 820 830 840 850
TDEILIVVQV NGKLRSKFSV DAAVSDDFIR KAALADEQVE KYIKGKTIKK
860
VIVVKKKLVN IVV
Length:863
Mass (Da):98,680
Last modified:May 5, 2009 - v1
Checksum:i1908E67EA74F6894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA Translation: ACN15811.1
RefSeqiWP_015904574.1, NC_012108.1

Genome annotation databases

EnsemblBacteriaiACN15811; ACN15811; HRM2_27190
KEGGidat:HRM2_27190

Similar proteinsi

Entry informationi

Entry nameiSYL_DESAH
AccessioniPrimary (citable) accession number: C0QI75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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