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C0QI75

- SYL_DESAH

UniProt

C0QI75 - SYL_DESAH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDAUT177437:GHLR-2718-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HRM2_27190
    OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
    Taxonomic identifieri177437 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
    ProteomesiUP000000442: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000202217Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177437.HRM2_27190.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QI75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QI75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERYNPEKV EPLWQAYWNQ HQTFKATEDG SKPKYYLLEM FPYPSGKIHM    50
    GHVRNYTIGD VVVRYKRMKG FNVLHPMGWD AFGMPAENAA IDNNTHPAAW 100
    TYENIRTMRR QLKRMGFSYD WDREIATCRP EYYRWEQWLF LKMLDKDMVY 150
    RKESYVNWCD HCQTVLANEQ VEQDMCWRCG KPVQQKKLWQ WFFRITDFAE 200
    DLLVHCDKLP GWPDNVTLMQ KNWIGKSQGS EIRFPIQGID ENIPVFTTRP 250
    DTLFGSTFMC LAPEHPLVET LSRGTDQAAA VTEFTTRVLN QERSSIALEK 300
    YEKEGVFTGA WCINPVTREK MPIYTANFAL MEYGTGAVMS VPAHDQRDFD 350
    FARKYGLPIK VVIQPPGEPL DPATMIEAYT GQGTLADSGE FSGLGNLEAM 400
    GAITRWLENK GLGKTTVSFR LRDWGISRQR YWGTPIPVIH CPDCGIVPVK 450
    EETLPVVLPE DAALLDNGGS PLATLDGFAR VNCPVCNRAD ARRETDTMDT 500
    FVESSWYFAR YCSPRYDKGM FDPAAVAYWM PVDQYIGGVE HAILHLLYSR 550
    YFMRVLNTLG LIDFKEPFER LLTQGMVCKE TLTCPEHGFI YPDDAETVND 600
    KVICKRCNSD VEVGRVIKMS KSKKNVIDPN ALLDQYGADI TRLFCLFAAP 650
    PEKDLEWNDD GVEGCNRFIN RVWRLADRCK STYIDLLPYS GVVADLKGEP 700
    KKLFIKANQT IKKVTDDIEE SFHFNTAISA VMELVNAMYS ADLDPDQTDM 750
    GEVALFCIEN IVLLLSPIVP HFCEELWSIL GHGPSIVDQP WPDYQKDALL 800
    TDEILIVVQV NGKLRSKFSV DAAVSDDFIR KAALADEQVE KYIKGKTIKK 850
    VIVVKKKLVN IVV 863
    Length:863
    Mass (Da):98,680
    Last modified:May 5, 2009 - v1
    Checksum:i1908E67EA74F6894
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN15811.1.
    RefSeqiWP_015904574.1. NC_012108.1.
    YP_002603975.1. NC_012108.1.

    Genome annotation databases

    EnsemblBacteriaiACN15811; ACN15811; HRM2_27190.
    GeneIDi7501492.
    KEGGidat:HRM2_27190.
    PATRICi21685143. VBIDesAut25181_2833.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN15811.1 .
    RefSeqi WP_015904574.1. NC_012108.1.
    YP_002603975.1. NC_012108.1.

    3D structure databases

    ProteinModelPortali C0QI75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177437.HRM2_27190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN15811 ; ACN15811 ; HRM2_27190 .
    GeneIDi 7501492.
    KEGGi dat:HRM2_27190.
    PATRICi 21685143. VBIDesAut25181_2833.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DAUT177437:GHLR-2718-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43914 / DSM 3382 / HRM2.

    Entry informationi

    Entry nameiSYL_DESAH
    AccessioniPrimary (citable) accession number: C0QI75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3