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C0QI75

- SYL_DESAH

UniProt

C0QI75 - SYL_DESAH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-2718-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HRM2_27190
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000202217Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_27190.

Structurei

3D structure databases

ProteinModelPortaliC0QI75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QI75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEERYNPEKV EPLWQAYWNQ HQTFKATEDG SKPKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYTIGD VVVRYKRMKG FNVLHPMGWD AFGMPAENAA IDNNTHPAAW
110 120 130 140 150
TYENIRTMRR QLKRMGFSYD WDREIATCRP EYYRWEQWLF LKMLDKDMVY
160 170 180 190 200
RKESYVNWCD HCQTVLANEQ VEQDMCWRCG KPVQQKKLWQ WFFRITDFAE
210 220 230 240 250
DLLVHCDKLP GWPDNVTLMQ KNWIGKSQGS EIRFPIQGID ENIPVFTTRP
260 270 280 290 300
DTLFGSTFMC LAPEHPLVET LSRGTDQAAA VTEFTTRVLN QERSSIALEK
310 320 330 340 350
YEKEGVFTGA WCINPVTREK MPIYTANFAL MEYGTGAVMS VPAHDQRDFD
360 370 380 390 400
FARKYGLPIK VVIQPPGEPL DPATMIEAYT GQGTLADSGE FSGLGNLEAM
410 420 430 440 450
GAITRWLENK GLGKTTVSFR LRDWGISRQR YWGTPIPVIH CPDCGIVPVK
460 470 480 490 500
EETLPVVLPE DAALLDNGGS PLATLDGFAR VNCPVCNRAD ARRETDTMDT
510 520 530 540 550
FVESSWYFAR YCSPRYDKGM FDPAAVAYWM PVDQYIGGVE HAILHLLYSR
560 570 580 590 600
YFMRVLNTLG LIDFKEPFER LLTQGMVCKE TLTCPEHGFI YPDDAETVND
610 620 630 640 650
KVICKRCNSD VEVGRVIKMS KSKKNVIDPN ALLDQYGADI TRLFCLFAAP
660 670 680 690 700
PEKDLEWNDD GVEGCNRFIN RVWRLADRCK STYIDLLPYS GVVADLKGEP
710 720 730 740 750
KKLFIKANQT IKKVTDDIEE SFHFNTAISA VMELVNAMYS ADLDPDQTDM
760 770 780 790 800
GEVALFCIEN IVLLLSPIVP HFCEELWSIL GHGPSIVDQP WPDYQKDALL
810 820 830 840 850
TDEILIVVQV NGKLRSKFSV DAAVSDDFIR KAALADEQVE KYIKGKTIKK
860
VIVVKKKLVN IVV
Length:863
Mass (Da):98,680
Last modified:May 5, 2009 - v1
Checksum:i1908E67EA74F6894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA. Translation: ACN15811.1.
RefSeqiWP_015904574.1. NC_012108.1.
YP_002603975.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN15811; ACN15811; HRM2_27190.
GeneIDi7501492.
KEGGidat:HRM2_27190.
PATRICi21685143. VBIDesAut25181_2833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA. Translation: ACN15811.1 .
RefSeqi WP_015904574.1. NC_012108.1.
YP_002603975.1. NC_012108.1.

3D structure databases

ProteinModelPortali C0QI75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177437.HRM2_27190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN15811 ; ACN15811 ; HRM2_27190 .
GeneIDi 7501492.
KEGGi dat:HRM2_27190.
PATRICi 21685143. VBIDesAut25181_2833.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DAUT177437:GHLR-2718-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2.

Entry informationi

Entry nameiSYL_DESAH
AccessioniPrimary (citable) accession number: C0QI75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3