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Protein

Thymidylate kinase

Gene

tmk

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:HRM2_26750
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
Proteomesi
  • UP000000442 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002036121 – 227Thymidylate kinaseAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_26750.

Structurei

3D structure databases

SMRiC0QI33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiFLYTADH.
OrthoDBiPOG091H02B9.

Family and domain databases

HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
PANTHERiPTHR10344:SF4. PTHR10344:SF4. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

C0QI33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFITLEGIEG SGKTTQIKPL VDCLGQNGYE AVVTREPGAT VIGKKIRAIL
60 70 80 90 100
LDPGNSGMSD LCELFLYGAD RAQHLSEVII PALGAGKTVV CDRFTDATTV
110 120 130 140 150
YQGAARGISK ELIDIIHSVV VKDLCPDLTI LFDLDPETGL ARTVKALTDG
160 170 180 190 200
ERTLDESRFE RETLEFHERV RQGYLALAAA EQDRFLVVDA RGTQEQVFTE
210 220
IVSGINRRLG IDLVGIDSAM IDPRVKG
Length:227
Mass (Da):24,705
Last modified:May 5, 2009 - v1
Checksum:iEB1A3D08FA15A174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA. Translation: ACN15769.1.
RefSeqiWP_015904532.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN15769; ACN15769; HRM2_26750.
KEGGidat:HRM2_26750.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKTHY_DESAH
AccessioniPrimary (citable) accession number: C0QI33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families