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C0QHN9

- C0QHN9_DESAH

UniProt

C0QHN9 - C0QHN9_DESAH

Protein

Alanine racemase

Gene

alr

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei327 – 3271Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDAUT177437:GHLR-483-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:HRM2_04830Imported
    OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)Imported
    Taxonomic identifieri177437 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
    ProteomesiUP000000442: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi177437.HRM2_04830.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QHN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiRITADEM.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QHN9-1 [UniParc]FASTAAdd to Basket

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    MKTENPPASL VWRQIDLDAI AHNLKTLRAL TKAHTAVMAV VKADAYGHGA    50
    VRVAKKALES GVTHLGVARL HEALELRNAG INAPILVFGY IPESDVDTLI 100
    ALEVSPTVFD LETACMLSER AVAKGTHIKI HLKVDTGMGR LGILPDSRRP 150
    SSEKKGALAE VLTISALPGL KIEGIYTHFA AADTLDKGYA EYQHQTFMAF 200
    IEGLKHLGIE IPLVHSANSA ALIDLPEAHF NMVRAGIAMY GLAPSGEVDI 250
    RSLDLRPAME IHSIITSVKK VPKSFKVSYG MTYETEKETV IAAVPIGYAD 300
    GFSRLFSSRG EMIVRGRKAP IAGRVCMDQT LIDVGEIPGV KPGDEVVILG 350
    TQANQRITAD EMAETIGTIN YEVISSLTAR VPKIYSE 387
    Length:387
    Mass (Da):41,769
    Last modified:May 5, 2009 - v1
    Checksum:i22F89F242D073C14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN13597.1.
    RefSeqiYP_002601761.1. NC_012108.1.

    Genome annotation databases

    EnsemblBacteriaiACN13597; ACN13597; HRM2_04830.
    GeneIDi7503286.
    KEGGidat:HRM2_04830.
    PATRICi21680449. VBIDesAut25181_0507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN13597.1 .
    RefSeqi YP_002601761.1. NC_012108.1.

    3D structure databases

    ProteinModelPortali C0QHN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177437.HRM2_04830.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN13597 ; ACN13597 ; HRM2_04830 .
    GeneIDi 7503286.
    KEGGi dat:HRM2_04830.
    PATRICi 21680449. VBIDesAut25181_0507.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi RITADEM.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci DAUT177437:GHLR-483-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43914 / DSM 3382 / HRM2Imported.

    Entry informationi

    Entry nameiC0QHN9_DESAH
    AccessioniPrimary (citable) accession number: C0QHN9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3