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C0QHM6

- PNP_DESAH

UniProt

C0QHM6 - PNP_DESAH

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, HRM2_04700
Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841Magnesium By similarity
Metal bindingi490 – 4901Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-470-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:HRM2_04700
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000381883Add
BLAST

Proteomic databases

PRIDEiC0QHM6.

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_04700.

Structurei

3D structure databases

ProteinModelPortaliC0QHM6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KHAdd
BLAST
Domaini620 – 68869S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiINTENDG.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QHM6-1 [UniParc]FASTAAdd to Basket

« Hide

MEQVFKTELN GKEFSLRAGK IAKQASGSVI VQYGETIVLV TAVAAKEARD    50
SVSFLPLTVE YQEKIYAAGR IPGNYFRREI GRPSEKETLT ARLIDRPIRP 100
LFEKGWASEI QVIATVISTD KENDPDVLAL VGASAALQMS DIPFAGPIAG 150
LRVGRIDGKF IANPTVQEME NSDIELVVAG SKTGVVMVEG GADVVSEADM 200
LEAIFFGHQA MQPLIQLQED LKKALGKEKR AYTPPLVDEE LMAKVVELAQ 250
DKIHTAVQTQ GKFERVKALD DVRTEVIETL GEAFADRINE IKSMFGDLVK 300
KVSRKIVLTE NQRIDGRAFD EVREITCEVG VLPRPHGSAL FTRGETQVLG 350
VLTLGSGPDE QRIETLNGNE TRNFMLHYNF PPFSVGECRR AGGPSRRDVG 400
HGNLAHRALA RVLPDQADFE YTIRLVGEVM ESNGSSSMGT VCAGTLALMD 450
GGVPIAAPVS GIAMGLVSDA DNTVVLTDIL GDEDHFGDMD FKVAGTEQGI 500
TALQMDIKIR ELPKAVLVKA LDQARIGRLH ILKRMLATLE IHRDKMSPYA 550
PKIITVKINP DKIREIIGPG GKMIRSIQAD TNTNIEVDDS GLIKIAAENQ 600
EDGEAAAKIV SDIGMDPEIG GIYEGEVVKT TDFGAFVRIK TGTDGLVHIS 650
ELANHRVKKV TDVVKEGEVI RVKVLEITRD GKIRLSCKAL EEEEK 695
Length:695
Mass (Da):75,737
Last modified:May 5, 2009 - v1
Checksum:i492B170347DA21A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN13584.1.
RefSeqiWP_012662833.1. NC_012108.1.
YP_002601748.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN13584; ACN13584; HRM2_04700.
GeneIDi7503273.
KEGGidat:HRM2_04700.
PATRICi21680421. VBIDesAut25181_0493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN13584.1 .
RefSeqi WP_012662833.1. NC_012108.1.
YP_002601748.1. NC_012108.1.

3D structure databases

ProteinModelPortali C0QHM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177437.HRM2_04700.

Proteomic databases

PRIDEi C0QHM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN13584 ; ACN13584 ; HRM2_04700 .
GeneIDi 7503273.
KEGGi dat:HRM2_04700.
PATRICi 21680421. VBIDesAut25181_0493.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi INTENDG.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DAUT177437:GHLR-470-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2.

Entry informationi

Entry nameiPNP_DESAH
AccessioniPrimary (citable) accession number: C0QHM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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