C0QGV9 (GLMM_DESAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	HRM2_25140

Organism

Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) [Complete proteome] [HAMAP]

Taxonomic identifier

177437 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfobacterium › Desulfobacterium autotrophicum

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP-Rule MF_01554
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP-Rule MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Post-translational modification	Activated by phosphorylation By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Phosphoglucosamine mutase HAMAP-Rule MF_01554		PRO_1000215486
Sites
	Active site	101	1	Phosphoserine intermediate By similarity
	Metal binding	101	1	Magnesium; via phosphate group By similarity
	Metal binding	256	1	Magnesium By similarity
	Metal binding	258	1	Magnesium By similarity
	Metal binding	260	1	Magnesium By similarity
Amino acid modifications
	Modified residue	101	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0QGV9 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: EF96AB514DD2E794	FASTA	463	49,305
	10 20 30 40 50 60 MGKLFGTDGI RGFANIYPMT VEVALKTGRA VARFAKEHGG TVVIIGRDTR RSGDMLEAAL 70 80 90 100 110 120 AAGISSMGIN VLEAGVIPTP GVAFLTATVK GAGAGVVISA SHNPFHDNGI KVFKSGGLKL 130 140 150 160 170 180 TDPEEAKIES YIFDAGPDRA DSSICEPKTS DSAIEPGTIS TISNASAQYA NFLTSCYQRD 190 200 210 220 230 240 LDKNTPDQPL KIVVDCSNGA SFKVAPMVFP TLGFETQFIF DTPDGKNINH NCGSQHTETL 250 260 270 280 290 300 AKRVISTGAD LGLAFDGDAD RLIAIDEQGV KLTGDKILAI CANHAKAQGR LTNNLVITTV 310 320 330 340 350 360 MSNIGLSKAL ERLGIDHIKT GVGDREVLKE MWATGAVMGG EDSGHMIFSE FHSTGDGILS 370 380 390 400 410 420 ALCLIRVMVD TNKSLSDLAT IMTVYPQVLM NVEVDPSRPD FMKIETIARE IKRVEQALNS 430 440 450 460 SGRVLVRYSG TQPLLRVMVE GPDLEATKSH CQSICDAIKQ ASI

References

[1]

"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide." Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R. Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001087 Genomic DNA. Translation: ACN15608.1.
RefSeq	YP_002603772.1. NC_012108.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	177437.HRM2_25140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN15608; ACN15608; HRM2_25140.
GeneID	7502304.
KEGG	dat:HRM2_25140.
PATRIC	21684731. VBIDesAut25181_2629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HOG000268678.
KO	K03431.
OMA	AQYSNIC.
Enzyme and pathway databases
BioCyc	DAUT177437:GHLR-2589-MONOMER.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
HAMAP	MF_01554_B. GlmM_B.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. glmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_DESAH

Accession

Primary (citable) accession number: C0QGV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program