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C0QGU2 (C0QGU2_DESAH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. SAAS SAAS020581

Catalytic activity

Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. SAAS SAAS020581

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020581

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. SAAS SAAS020581

Sequences

Sequence LengthMass (Da)Tools
C0QGU2 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 2AC6877BD58A4388

FASTA49553,447
        10         20         30         40         50         60 
METPNKTGLE PETGNGTQGL IFKEPLLWEK SKPGRCGISI PLADVEVSPL DPDLVGEAPE 

        70         80         90        100        110        120 
LPELYELDVV RHYTRLSQWN IGIDSAMYPL GSCTMKYNPK TNDVQAARIG FAAAHPLADP 

       130        140        150        160        170        180 
DLSQGALELM HTLEGFLAEI AGMAATTLQP AAGAHGELTG MMIIHAYHAK NGRQRTKILI 

       190        200        210        220        230        240 
PDTAHGTNPA SAALCGYSPV NITSSELGML TPKAVADAMD EDTAGIMITN PNTLGLFEED 

       250        260        270        280        290        300 
LKEICDIVHQ KGGLVYGDGA NMNAVLGIVR PGDLGMDVVH YNLHKTFSTP HGGGGPGSGP 

       310        320        330        340        350        360 
ISVVEKLVPF LPGPRIVKDD KGFSFKEKGP DSIGRMLTFY GHFGILVRAY AYIRSLGPDG 

       370        380        390        400        410        420 
LKRVSQLAVL NANYIKESLK DTLDLAYDRP CMHECVFSDK GQAPHKVTTL DMAKRLMDYG 

       430        440        450        460        470        480 
FHPPTIYFPL VVHGALMIEP TETESKETID GLIHALKAIA EEARTNPDLV RSAPHLPKMQ 

       490 
RLDEVTAARK PCLCG

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References

[1]"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide."
Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R.
Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001087 Genomic DNA. Translation: ACN15591.1.
RefSeqYP_002603755.1. NC_012108.1.

3D structure databases

ProteinModelPortalC0QGU2.
ModBaseSearch...

Protein-protein interaction databases

STRING177437.HRM2_24970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN15591; ACN15591; HRM2_24970.
GeneID7502287.
KEGGdat:HRM2_24970.
PATRIC21684697. VBIDesAut25181_2612.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMARHYTRLS.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycDAUT177437:GHLR-2572-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0QGU2_DESAH
AccessionPrimary (citable) accession number: C0QGU2
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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