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C0QFM5

- PNCB_DESAH

UniProt

C0QFM5 - PNCB_DESAH

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-299-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:HRM2_02990
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Nicotinate phosphoribosyltransferasePRO_1000212082Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_02990.

Structurei

3D structure databases

ProteinModelPortaliC0QFM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

C0QFM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQSILDNDL YKFTMQQAVH MLYPRVDVEY EFINRSNTPF PKDFAQRLQV
60 70 80 90 100
EVQGMKNFRL TPEEKEYLDK TCYFMTPVYL DFLEHYTFDP DEVTVSQTNS
110 120 130 140 150
ELSVTIKGPW YRTILWEVPL MAIISELYFV MTNARPLPDE QIRVINLNKA
160 170 180 190 200
KILSCNNIRY ADFGTRRRFS SSGHEALIRD ILALEHNTLI GTSNVNLARL
210 220 230 240 250
FNIKPIGTMA HEWIMFHGVL NGYRMANPTA VAAWATAFHG HLGIALTDTF
260 270 280 290 300
TTDIFLSTFD TLHAKLFDGV RHDSGDPIAF IDRIVDHYKK LHIDPITKTI
310 320 330 340 350
VFSDGLDIDK AVHIHNHCIN RIRDSYGIGT NLTNDVGVTP LNMVIKLAKC
360 370 380
RTAPEKDWHN AIKLSDDKGK HTGDSEELAH CIKVLERGM
Length:389
Mass (Da):44,546
Last modified:May 5, 2009 - v1
Checksum:i636081A7C7F61EC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN13421.1.
RefSeqiWP_012662670.1. NC_012108.1.
YP_002601585.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN13421; ACN13421; HRM2_02990.
GeneIDi7499302.
KEGGidat:HRM2_02990.
PATRICi21680055. VBIDesAut25181_0315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN13421.1 .
RefSeqi WP_012662670.1. NC_012108.1.
YP_002601585.1. NC_012108.1.

3D structure databases

ProteinModelPortali C0QFM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177437.HRM2_02990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN13421 ; ACN13421 ; HRM2_02990 .
GeneIDi 7499302.
KEGGi dat:HRM2_02990.
PATRICi 21680055. VBIDesAut25181_0315.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci DAUT177437:GHLR-299-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2.

Entry informationi

Entry nameiPNCB_DESAH
AccessioniPrimary (citable) accession number: C0QFM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3