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C0QFM5 (PNCB_DESAH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:HRM2_02990
OrganismDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) [Complete proteome] [HAMAP]
Taxonomic identifier177437 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000212082

Sequences

Sequence LengthMass (Da)Tools
C0QFM5 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 636081A7C7F61EC1

FASTA38944,546
        10         20         30         40         50         60 
MIQSILDNDL YKFTMQQAVH MLYPRVDVEY EFINRSNTPF PKDFAQRLQV EVQGMKNFRL 

        70         80         90        100        110        120 
TPEEKEYLDK TCYFMTPVYL DFLEHYTFDP DEVTVSQTNS ELSVTIKGPW YRTILWEVPL 

       130        140        150        160        170        180 
MAIISELYFV MTNARPLPDE QIRVINLNKA KILSCNNIRY ADFGTRRRFS SSGHEALIRD 

       190        200        210        220        230        240 
ILALEHNTLI GTSNVNLARL FNIKPIGTMA HEWIMFHGVL NGYRMANPTA VAAWATAFHG 

       250        260        270        280        290        300 
HLGIALTDTF TTDIFLSTFD TLHAKLFDGV RHDSGDPIAF IDRIVDHYKK LHIDPITKTI 

       310        320        330        340        350        360 
VFSDGLDIDK AVHIHNHCIN RIRDSYGIGT NLTNDVGVTP LNMVIKLAKC RTAPEKDWHN 

       370        380 
AIKLSDDKGK HTGDSEELAH CIKVLERGM 

« Hide

References

[1]"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide."
Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R.
Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001087 Genomic DNA. Translation: ACN13421.1.
RefSeqYP_002601585.1. NC_012108.1.

3D structure databases

ProteinModelPortalC0QFM5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177437.HRM2_02990.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN13421; ACN13421; HRM2_02990.
GeneID7499302.
KEGGdat:HRM2_02990.
PATRIC21680055. VBIDesAut25181_0315.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG6X10XB.
ProtClustDBPRK05321.

Enzyme and pathway databases

BioCycDAUT177437:GHLR-299-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_DESAH
AccessionPrimary (citable) accession number: C0QFM5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: March 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways