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C0QFM5

- PNCB_DESAH

UniProt

C0QFM5 - PNCB_DESAH

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciDAUT177437:GHLR-299-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:HRM2_02990
    OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
    Taxonomic identifieri177437 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
    ProteomesiUP000000442: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Nicotinate phosphoribosyltransferasePRO_1000212082Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177437.HRM2_02990.

    Structurei

    3D structure databases

    ProteinModelPortaliC0QFM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiSIVCKVI.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0QFM5-1 [UniParc]FASTAAdd to Basket

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    MIQSILDNDL YKFTMQQAVH MLYPRVDVEY EFINRSNTPF PKDFAQRLQV    50
    EVQGMKNFRL TPEEKEYLDK TCYFMTPVYL DFLEHYTFDP DEVTVSQTNS 100
    ELSVTIKGPW YRTILWEVPL MAIISELYFV MTNARPLPDE QIRVINLNKA 150
    KILSCNNIRY ADFGTRRRFS SSGHEALIRD ILALEHNTLI GTSNVNLARL 200
    FNIKPIGTMA HEWIMFHGVL NGYRMANPTA VAAWATAFHG HLGIALTDTF 250
    TTDIFLSTFD TLHAKLFDGV RHDSGDPIAF IDRIVDHYKK LHIDPITKTI 300
    VFSDGLDIDK AVHIHNHCIN RIRDSYGIGT NLTNDVGVTP LNMVIKLAKC 350
    RTAPEKDWHN AIKLSDDKGK HTGDSEELAH CIKVLERGM 389
    Length:389
    Mass (Da):44,546
    Last modified:May 5, 2009 - v1
    Checksum:i636081A7C7F61EC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN13421.1.
    RefSeqiYP_002601585.1. NC_012108.1.

    Genome annotation databases

    EnsemblBacteriaiACN13421; ACN13421; HRM2_02990.
    GeneIDi7499302.
    KEGGidat:HRM2_02990.
    PATRICi21680055. VBIDesAut25181_0315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN13421.1 .
    RefSeqi YP_002601585.1. NC_012108.1.

    3D structure databases

    ProteinModelPortali C0QFM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177437.HRM2_02990.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN13421 ; ACN13421 ; HRM2_02990 .
    GeneIDi 7499302.
    KEGGi dat:HRM2_02990.
    PATRICi 21680055. VBIDesAut25181_0315.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi SIVCKVI.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci DAUT177437:GHLR-299-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43914 / DSM 3382 / HRM2.

    Entry informationi

    Entry nameiPNCB_DESAH
    AccessioniPrimary (citable) accession number: C0QFM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3