C0QFM5 (PNCB_DESAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	HRM2_02990

Organism

Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) [Complete proteome] [HAMAP]

Taxonomic identifier

177437 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfobacterium › Desulfobacterium autotrophicum

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000212082

Sequences

	Sequence		Length	Mass (Da)
	C0QFM5 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 636081A7C7F61EC1	FASTA	389	44,546
	10 20 30 40 50 60 MIQSILDNDL YKFTMQQAVH MLYPRVDVEY EFINRSNTPF PKDFAQRLQV EVQGMKNFRL 70 80 90 100 110 120 TPEEKEYLDK TCYFMTPVYL DFLEHYTFDP DEVTVSQTNS ELSVTIKGPW YRTILWEVPL 130 140 150 160 170 180 MAIISELYFV MTNARPLPDE QIRVINLNKA KILSCNNIRY ADFGTRRRFS SSGHEALIRD 190 200 210 220 230 240 ILALEHNTLI GTSNVNLARL FNIKPIGTMA HEWIMFHGVL NGYRMANPTA VAAWATAFHG 250 260 270 280 290 300 HLGIALTDTF TTDIFLSTFD TLHAKLFDGV RHDSGDPIAF IDRIVDHYKK LHIDPITKTI 310 320 330 340 350 360 VFSDGLDIDK AVHIHNHCIN RIRDSYGIGT NLTNDVGVTP LNMVIKLAKC RTAPEKDWHN 370 380 AIKLSDDKGK HTGDSEELAH CIKVLERGM

References

[1]

"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide." Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R. Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001087 Genomic DNA. Translation: ACN13421.1.
RefSeq	YP_002601585.1. NC_012108.1.
3D structure databases
ProteinModelPortal	C0QFM5.
ModBase	Search...
Protein-protein interaction databases
STRING	177437.HRM2_02990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN13421; ACN13421; HRM2_02990.
GeneID	7499302.
KEGG	dat:HRM2_02990.
PATRIC	21680055. VBIDesAut25181_0315.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	NEQLDHL.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	DAUT177437:GHLR-375-MONOMER.
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_DESAH

Accession

Primary (citable) accession number: C0QFM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program