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C0QAX9 (FTHS_DESAH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:HRM2_16700
OrganismDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2) [Complete proteome] [HAMAP]
Taxonomic identifier177437 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000215434

Regions

Nucleotide binding74 – 818ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C0QAX9 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 136606B37A755835

FASTA59163,927
        10         20         30         40         50         60 
MALDPTKHAD WEIAQDAEKD MLTIYEIGEK LGLTKEELLP QGHYIAKIDF RAVLARLKDK 

        70         80         90        100        110        120 
PDGKYIDVTA ITPTPLGEGK STSSMGLVQG LGKLGKSVCA AIRQPSGGPT MNIKGSAAGG 

       130        140        150        160        170        180 
GLAQCIPLTP FSLGFTGDIN AIMNAHNLAM VALTSRMQHE RNYTDEQLER LSGMKRIDID 

       190        200        210        220        230        240 
PTRVEMGWIM DFCCQSLRNI IIGIDGVNGK SDGYMMKSKF GIAVSSEVMA ILAVAKDLKD 

       250        260        270        280        290        300 
MRERMGKIVV AYTKKGKPVT TEDLQVAGAM TAWMVDALNP SLIQTLEGQP VLVHAGPFAN 

       310        320        330        340        350        360 
IAIGQSSIIA DRVGLKLADY HVTESGFGAD IGFEKFWNLK CRFSGLKPDC AVIVATIRAL 

       370        380        390        400        410        420 
KCHGGAPVPV PGKPMPEEYN TESVEWVEKG CANLLHHIRN VRKAGISPVV CINAFYSDTD 

       430        440        450        460        470        480 
AEIAKVRELS EAEGARVALS RHWEKGGDGA IEFAETVIEA CEEETEFKFL YELDMPLKER 

       490        500        510        520        530        540 
IELIAKEVYG ADGVDYSNEA NASLARIQAD PELAKLGMCM VKTHLSLSDN PSLKGVPTGW 

       550        560        570        580        590 
RLMIREVLTY GGAGFIVPVA GTISLMPGTG SNPAFKRVDV DCETGKVEGV F 

« Hide

References

[1]"Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide."
Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S., Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A., Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O., Meyerdierks A., Gottschalk G., Amann R.
Environ. Microbiol. 11:1038-1055(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43914 / DSM 3382 / HRM2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001087 Genomic DNA. Translation: ACN14778.1.
RefSeqYP_002602940.1. NC_012108.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177437.HRM2_16700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN14778; ACN14778; HRM2_16700.
GeneID7499119.
KEGGdat:HRM2_16700.
PATRIC21683007. VBIDesAut25181_1780.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13507.

Enzyme and pathway databases

BioCycDAUT177437:GHLR-1670-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DESAH
AccessionPrimary (citable) accession number: C0QAX9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways