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C0QAX9

- FTHS_DESAH

UniProt

C0QAX9 - FTHS_DESAH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDAUT177437:GHLR-1670-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:HRM2_16700
    OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
    Taxonomic identifieri177437 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
    ProteomesiUP000000442: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Formate--tetrahydrofolate ligasePRO_1000215434Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177437.HRM2_16700.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiACEEETE.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0QAX9-1 [UniParc]FASTAAdd to Basket

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    MALDPTKHAD WEIAQDAEKD MLTIYEIGEK LGLTKEELLP QGHYIAKIDF    50
    RAVLARLKDK PDGKYIDVTA ITPTPLGEGK STSSMGLVQG LGKLGKSVCA 100
    AIRQPSGGPT MNIKGSAAGG GLAQCIPLTP FSLGFTGDIN AIMNAHNLAM 150
    VALTSRMQHE RNYTDEQLER LSGMKRIDID PTRVEMGWIM DFCCQSLRNI 200
    IIGIDGVNGK SDGYMMKSKF GIAVSSEVMA ILAVAKDLKD MRERMGKIVV 250
    AYTKKGKPVT TEDLQVAGAM TAWMVDALNP SLIQTLEGQP VLVHAGPFAN 300
    IAIGQSSIIA DRVGLKLADY HVTESGFGAD IGFEKFWNLK CRFSGLKPDC 350
    AVIVATIRAL KCHGGAPVPV PGKPMPEEYN TESVEWVEKG CANLLHHIRN 400
    VRKAGISPVV CINAFYSDTD AEIAKVRELS EAEGARVALS RHWEKGGDGA 450
    IEFAETVIEA CEEETEFKFL YELDMPLKER IELIAKEVYG ADGVDYSNEA 500
    NASLARIQAD PELAKLGMCM VKTHLSLSDN PSLKGVPTGW RLMIREVLTY 550
    GGAGFIVPVA GTISLMPGTG SNPAFKRVDV DCETGKVEGV F 591
    Length:591
    Mass (Da):63,927
    Last modified:May 5, 2009 - v1
    Checksum:i136606B37A755835
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN14778.1.
    RefSeqiYP_002602940.1. NC_012108.1.

    Genome annotation databases

    EnsemblBacteriaiACN14778; ACN14778; HRM2_16700.
    GeneIDi7499119.
    KEGGidat:HRM2_16700.
    PATRICi21683007. VBIDesAut25181_1780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001087 Genomic DNA. Translation: ACN14778.1 .
    RefSeqi YP_002602940.1. NC_012108.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177437.HRM2_16700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN14778 ; ACN14778 ; HRM2_16700 .
    GeneIDi 7499119.
    KEGGi dat:HRM2_16700.
    PATRICi 21683007. VBIDesAut25181_1780.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi ACEEETE.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DAUT177437:GHLR-1670-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43914 / DSM 3382 / HRM2.

    Entry informationi

    Entry nameiFTHS_DESAH
    AccessioniPrimary (citable) accession number: C0QAX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3