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C0QAX9

- FTHS_DESAH

UniProt

C0QAX9 - FTHS_DESAH

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, HRM2_16700
Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 818ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-1670-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:HRM2_16700
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000215434Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_16700.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiACEEETE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0QAX9-1 [UniParc]FASTAAdd to Basket

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MALDPTKHAD WEIAQDAEKD MLTIYEIGEK LGLTKEELLP QGHYIAKIDF    50
RAVLARLKDK PDGKYIDVTA ITPTPLGEGK STSSMGLVQG LGKLGKSVCA 100
AIRQPSGGPT MNIKGSAAGG GLAQCIPLTP FSLGFTGDIN AIMNAHNLAM 150
VALTSRMQHE RNYTDEQLER LSGMKRIDID PTRVEMGWIM DFCCQSLRNI 200
IIGIDGVNGK SDGYMMKSKF GIAVSSEVMA ILAVAKDLKD MRERMGKIVV 250
AYTKKGKPVT TEDLQVAGAM TAWMVDALNP SLIQTLEGQP VLVHAGPFAN 300
IAIGQSSIIA DRVGLKLADY HVTESGFGAD IGFEKFWNLK CRFSGLKPDC 350
AVIVATIRAL KCHGGAPVPV PGKPMPEEYN TESVEWVEKG CANLLHHIRN 400
VRKAGISPVV CINAFYSDTD AEIAKVRELS EAEGARVALS RHWEKGGDGA 450
IEFAETVIEA CEEETEFKFL YELDMPLKER IELIAKEVYG ADGVDYSNEA 500
NASLARIQAD PELAKLGMCM VKTHLSLSDN PSLKGVPTGW RLMIREVLTY 550
GGAGFIVPVA GTISLMPGTG SNPAFKRVDV DCETGKVEGV F 591
Length:591
Mass (Da):63,927
Last modified:May 5, 2009 - v1
Checksum:i136606B37A755835
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN14778.1.
RefSeqiYP_002602940.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN14778; ACN14778; HRM2_16700.
GeneIDi7499119.
KEGGidat:HRM2_16700.
PATRICi21683007. VBIDesAut25181_1780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001087 Genomic DNA. Translation: ACN14778.1 .
RefSeqi YP_002602940.1. NC_012108.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177437.HRM2_16700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN14778 ; ACN14778 ; HRM2_16700 .
GeneIDi 7499119.
KEGGi dat:HRM2_16700.
PATRICi 21683007. VBIDesAut25181_1780.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi ACEEETE.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DAUT177437:GHLR-1670-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2.

Entry informationi

Entry nameiFTHS_DESAH
AccessioniPrimary (citable) accession number: C0QAX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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