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Protein

D-alanine--D-alanine ligase

Gene

ddlB2

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDAUT177437:GHLR-1324-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Name:ddlB2Imported
Ordered Locus Names:HRM2_13240Imported
OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)Imported
Taxonomic identifieri177437 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
ProteomesiUP000000442 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi177437.HRM2_13240.

Structurei

3D structure databases

ProteinModelPortaliC0Q8U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiSREAQIP.
OrthoDBiEOG66MQKK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0Q8U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIGITYDLR QDYLDMGYTE LETAEFDSVE TIEAIETTLQ GLGHETRRIG
60 70 80 90 100
NAIRLTERLV QGERWDLVFN IAEGLHGIGR EAQIPAILDL YNIPYTFSDP
110 120 130 140 150
MVMAVTLHKG MTKHIIRDAG LATADFKVAN SARDAWNLPF DPPFFVKPVA
160 170 180 190 200
EGTGMGITAK SLVKNALDLP GVCQELVEQF HQPVLIEEFL TGREFTVGIV
210 220 230 240 250
GTGTRAQVMG TMEIIVISSK KDEVYSFENK EGWKSKVQYL PLSPGTDPLI
260 270 280 290 300
QAVEDLALSA WKVLGCRDGG RIDIRCDAAG RPSFIEVNPL AGLRPEYSDL
310 320 330
PIVCQFFGTS YVQLIELILE SAMERVPVLE TA
Length:332
Mass (Da):36,753
Last modified:May 5, 2009 - v1
Checksum:iEDC71F94E221DA6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA. Translation: ACN14435.1.
RefSeqiWP_015903222.1. NC_012108.1.
YP_002602599.1. NC_012108.1.

Genome annotation databases

EnsemblBacteriaiACN14435; ACN14435; HRM2_13240.
KEGGidat:HRM2_13240.
PATRICi21682289. VBIDesAut25181_1424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA. Translation: ACN14435.1.
RefSeqiWP_015903222.1. NC_012108.1.
YP_002602599.1. NC_012108.1.

3D structure databases

ProteinModelPortaliC0Q8U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177437.HRM2_13240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACN14435; ACN14435; HRM2_13240.
KEGGidat:HRM2_13240.
PATRICi21682289. VBIDesAut25181_1424.

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiSREAQIP.
OrthoDBiEOG66MQKK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciDAUT177437:GHLR-1324-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43914 / DSM 3382 / HRM2Imported.

Entry informationi

Entry nameiC0Q8U5_DESAH
AccessioniPrimary (citable) accession number: C0Q8U5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.