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C0Q772

- NAGK_SALPC

UniProt

C0Q772 - NAGK_SALPC

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Protein

N-acetyl-D-glucosamine kinase

Gene
nagK, SPC_2525
Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Zinc By similarity
Metal bindingi177 – 1771Zinc By similarity
Metal bindingi179 – 1791Zinc By similarity
Metal bindingi184 – 1841Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATP Reviewed prediction
Nucleotide bindingi133 – 1408ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSENT476213:GH8J-2565-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:SPC_2525
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001599: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinaseUniRule annotationPRO_1000165175Add
BLAST

Proteomic databases

PRIDEiC0Q772.

Interactioni

Protein-protein interaction databases

STRINGi476213.SPC_2525.

Structurei

3D structure databases

ProteinModelPortaliC0Q772.
SMRiC0Q772. Positions 1-303.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
OMAiMESINES.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0Q772-1 [UniParc]FASTAAdd to Basket

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MYYGFDIGGT KIALGAFDST RRLQWEKRVP TPHTSYSAFL DAVCELVAEA    50
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY 150
ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH 200
YYDQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV 250
IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH 300
LTD 303
Length:303
Mass (Da):32,974
Last modified:May 5, 2009 - v1
Checksum:i8B686506EBBE8F6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN46630.1.
RefSeqiYP_002638071.1. NC_012125.1.

Genome annotation databases

EnsemblBacteriaiACN46630; ACN46630; SPC_2525.
PATRICi32363973. VBISalEnt12305_2598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN46630.1 .
RefSeqi YP_002638071.1. NC_012125.1.

3D structure databases

ProteinModelPortali C0Q772.
SMRi C0Q772. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 476213.SPC_2525.

Proteomic databases

PRIDEi C0Q772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN46630 ; ACN46630 ; SPC_2525 .
PATRICi 32363973. VBISalEnt12305_2598.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
OMAi MESINES.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci SENT476213:GH8J-2565-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
    Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
    PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS4594.

Entry informationi

Entry nameiNAGK_SALPC
AccessioniPrimary (citable) accession number: C0Q772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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