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Protein

Crotonobetaine/carnitine--CoA ligase

Gene

caiC

Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.UniRule annotation

Catalytic activityi

ATP + 4-(trimethylamino)butanoate + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA.UniRule annotation
ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA.UniRule annotation
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase

Enzyme and pathway databases

UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:SPC_0076
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001599 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001851301 – 517Crotonobetaine/carnitine--CoA ligaseAdd BLAST517

Structurei

3D structure databases

ProteinModelPortaliC0Q4L3
SMRiC0Q4L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230001
KOiK02182
OMAiWLMQRAF

Family and domain databases

HAMAPiMF_01524 CaiC, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023456 CaiC
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

C0Q4L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIVGGQNLR QMWDDLAGVY GDKTALIFES CEGIVRQFSY ASLNEEINRT
60 70 80 90 100
ANLFYSLGIR KGDRVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLGEE
110 120 130 140 150
SAWILQNSQV SLLVTSVQFY PMYREIHQDN STPLNHICLI GEQLPADDGV
160 170 180 190 200
SHFSQLQARQ SATLCYTPAL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQIA LRDDDVYMTV MPAFHIDCQC TAAMPAFSAG STFVLLEKYS
260 270 280 290 300
ARAFWDQVRR YQATVTECIP MMIRTLMVQP AAPTDRQHHL REVMFYLNLS
310 320 330 340 350
AQEKDAFTER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRVGFSYE
360 370 380 390 400
AEIRDDQNRP LPAGEIGEIC IKGIPGKTIF KEYYMQPEAT AGALEPEGWL
410 420 430 440 450
HTGDSGYQDE DGYFYFVDRR CNMIKRGGEN VSCVELENII SAHPKIQDIV
460 470 480 490 500
VVGIKDAIRD EAIKAFIVLN EGETLSEAEF FSFCENNMAK FKVPSFMEIR
510
TDLPRNCSGK IIKKNLK
Length:517
Mass (Da):58,310
Last modified:May 5, 2009 - v1
Checksum:iC9B1D675F56F3A91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000857 Genomic DNA Translation: ACN44268.1
RefSeqiWP_000355814.1, NC_012125.1

Genome annotation databases

EnsemblBacteriaiACN44268; ACN44268; SPC_0076
KEGGisei:SPC_0076

Similar proteinsi

Entry informationi

Entry nameiCAIC_SALPC
AccessioniPrimary (citable) accession number: C0Q4L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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