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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSENT476213:GH8J-4103-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:SPC_4027
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001599 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000185315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi476213.SPC_4027.

Structurei

3D structure databases

ProteinModelPortaliC0Q2V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
OMAiQKKLLAC.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.

Sequencei

Sequence statusi: Complete.

C0Q2V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSLYAAI DLGSNSFHML VVREAAESIQ TLTRIKRKVR LAAGLNNDNH
60 70 80 90 100
LSAEAMERGW QCLRLFAERL QDIPQPQIRV VATATLRLAV NAGEFIAKAQ
110 120 130 140 150
TILGCPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG
160 170 180 190 200
AQTTSLFSLS MGCVTWLERY FSDRNLAQEN FDDAEKAARD VLRPVADELR
210 220 230 240 250
FHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE
260 270 280 290 300
LEIEGLTLER ALVFPSGLAI LIAIFTELNI QSMTLAGGAL REGLVYGMLH
310 320 330 340 350
LAVDQDIRSR TLRNIQRRFI VDTDQANRVA KLADNFLKQV ENAWHIEPIS
360 370 380 390 400
RELLLSACQL HEIGLSVDFK QAPYHAAYLV RHLDLPGYTP AQKKLLATLL
410 420 430 440 450
LNQTNPVDLS SLHQQNAVPP RVAEQLCRLL RLAILFAGRR RDDLVPEITL
460 470 480 490
RALNENLTLT LPGDWLAHHP LGKELIDQES QWQSYVHWPL DVR
Length:493
Mass (Da):54,916
Last modified:May 5, 2009 - v1
Checksum:i5C42E0C9F3A6B786
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000857 Genomic DNA. Translation: ACN48094.1.
RefSeqiWP_001089444.1. NC_012125.1.
YP_002639535.1. NC_012125.1.

Genome annotation databases

EnsemblBacteriaiACN48094; ACN48094; SPC_4027.
PATRICi32367046. VBISalEnt12305_4089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000857 Genomic DNA. Translation: ACN48094.1.
RefSeqiWP_001089444.1. NC_012125.1.
YP_002639535.1. NC_012125.1.

3D structure databases

ProteinModelPortaliC0Q2V8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi476213.SPC_4027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACN48094; ACN48094; SPC_4027.
PATRICi32367046. VBISalEnt12305_4089.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
OMAiQKKLLAC.
OrthoDBiEOG6M6JN6.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciSENT476213:GH8J-4103-MONOMER.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
    Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
    PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS4594.

Entry informationi

Entry nameiGPPA_SALPC
AccessioniPrimary (citable) accession number: C0Q2V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: April 1, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.