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C0Q2A0

- DCYD_SALPC

UniProt

C0Q2A0 - DCYD_SALPC

Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

    Catalytic activityi

    D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-amino acid metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSENT476213:GH8J-1793-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
    Gene namesi
    Name:dcyDUniRule annotation
    Ordered Locus Names:SPC_1761
    OrganismiSalmonella paratyphi C (strain RKS4594)
    Taxonomic identifieri476213 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001599: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328D-cysteine desulfhydrasePRO_1000149602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi476213.SPC_1761.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2515.
    HOGENOMiHOG000022459.
    OMAiPYLVPIG.
    OrthoDBiEOG6FBX0P.

    Family and domain databases

    HAMAPiMF_01045. D_Cys_desulfhydr.
    InterProiIPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0Q2A0-1 [UniParc]FASTAAdd to Basket

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    MPLHHLTRFP RLELIGAPTP LEYLPRLSDY LGREIYIKRD DVTPIAMGGN    50
    KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTVAVAAK LGLHCVALLE 100
    NPIGTTAENY LTNGNRLLLD LFNTQIEMCD ALTDPDAQLQ TLATRIEAQG 150
    FRPYVIPVGG SSALGAMGYV ESALEIAQQC AEVVGLSSVV VASGSAGTHA 200
    GLAVGLEHLM PDVELIGVTV SRSVAEQKPR VISLQQAIAG QLALTATADI 250
    HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS 300
    QKRFNDDGPI LFIHTGGAPA LFAYHPHV 328
    Length:328
    Mass (Da):34,891
    Last modified:May 5, 2009 - v1
    Checksum:i6CEB4AF1A28DCDF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000857 Genomic DNA. Translation: ACN45903.1.
    RefSeqiWP_001128193.1. NC_012125.1.
    YP_002637344.1. NC_012125.1.

    Genome annotation databases

    EnsemblBacteriaiACN45903; ACN45903; SPC_1761.
    PATRICi32362377. VBISalEnt12305_1809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000857 Genomic DNA. Translation: ACN45903.1 .
    RefSeqi WP_001128193.1. NC_012125.1.
    YP_002637344.1. NC_012125.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 476213.SPC_1761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN45903 ; ACN45903 ; SPC_1761 .
    PATRICi 32362377. VBISalEnt12305_1809.

    Phylogenomic databases

    eggNOGi COG2515.
    HOGENOMi HOG000022459.
    OMAi PYLVPIG.
    OrthoDBi EOG6FBX0P.

    Enzyme and pathway databases

    BioCyci SENT476213:GH8J-1793-MONOMER.

    Family and domain databases

    HAMAPi MF_01045. D_Cys_desulfhydr.
    InterProi IPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
      Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
      PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RKS4594.

    Entry informationi

    Entry nameiDCYD_SALPC
    AccessioniPrimary (citable) accession number: C0Q2A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3