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C0PZ54

- IF2_SALPC

UniProt

C0PZ54 - IF2_SALPC

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi400 – 4078GTPUniRule annotation
    Nucleotide bindingi446 – 4505GTPUniRule annotation
    Nucleotide bindingi500 – 5034GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT476213:GH8J-3410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:SPC_3357
    OrganismiSalmonella paratyphi C (strain RKS4594)
    Taxonomic identifieri476213 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001599: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Translation initiation factor IF-2PRO_1000118772Add
    BLAST

    Proteomic databases

    PRIDEiC0PZ54.

    Interactioni

    Protein-protein interaction databases

    STRINGi476213.SPC_3357.

    Structurei

    3D structure databases

    ProteinModelPortaliC0PZ54.
    SMRiC0PZ54. Positions 2-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini391 – 560170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni400 – 4078G1By similarity
    Regioni425 – 4295G2By similarity
    Regioni446 – 4494G3By similarity
    Regioni500 – 5034G4By similarity
    Regioni536 – 5383G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    OMAiDNRTGGY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0PZ54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVTLKALA AERQVSVDRL VQQFADAGIR KSADDSVSAQ EKQTLLAHLN    50
    REAVSGPDKL TLQRKTRSTL NIPGTGGKSK SVQIEVRKKR TFVKRDPQEA 100
    ERLAAEEQAQ REAEEQARRE AEEQAKREAQ QKAEREAAEQ AKREAAEKAK 150
    REAAEKDKVS NQQTDDMTKT AQAEKARREN EAAELKRKAE EEARRKLEEE 200
    ARRVAEEARR MAEENKWTAT PEPVEDTSDY HVTTSQHARQ AEDENDREVE 250
    GGRGRGRNAK AARPAKKGKH AESKADREEA RAAVRGGKGG KRKGSSLQQG 300
    FQKPAQAVNR DVVIGETITV GELANKMAVK GSQVIKAMMK LGAMATINQV 350
    IDQETAQLVA EEMGHKVILR RENELEEAVM SDRDTGAAAE PRAPVVTIMG 400
    HVDHGKTSLL DYIRSTKVAS GEAGGITQHI GAYHVETDNG MITFLDTPGH 450
    AAFTSMRARG AQATDIVVLV VAADDGVMPQ TIEAIQHAKA AGVPVVVAVN 500
    KIDKPEADPD RVKNELSQYG ILPEEWGGES QFVHVSAKAG TGIDELLDAI 550
    LLQAEVLELK AVRKGMASGA VIESFLDKGR GPVATVLVRE GTLHKGDIVL 600
    CGFEYGRVRA MRNELGQEVL EAGPSIPVEI LGLSGVPAAG DEVTVVRDEK 650
    KAREVALYRQ GKFREVKLAR QQKSKLENMF ANMTEGEVHE VNIVLKADVQ 700
    GSVEAISDSL LKLSTDEVKV KIIGSGVGGI TETDATLAAA SNAILVGFNV 750
    RADASARKVI ESESLDLRYY SVIYNLIDEV KAAMSGMLSP ELKQQIIGLA 800
    EVRDVFKSPK FGAIAGCMVT EGTIKRHNPI RVLRDNVVIY EGELESLRRF 850
    KDDVNEVRNG MECGIGVKNY NDVRVGDMIE VFEIIEIQRT IA 892
    Length:892
    Mass (Da):97,402
    Last modified:May 5, 2009 - v1
    Checksum:i0D690F8E64505885
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000857 Genomic DNA. Translation: ACN47442.1.
    RefSeqiYP_002638883.1. NC_012125.1.

    Genome annotation databases

    EnsemblBacteriaiACN47442; ACN47442; SPC_3357.
    PATRICi32365648. VBISalEnt12305_3417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000857 Genomic DNA. Translation: ACN47442.1 .
    RefSeqi YP_002638883.1. NC_012125.1.

    3D structure databases

    ProteinModelPortali C0PZ54.
    SMRi C0PZ54. Positions 2-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 476213.SPC_3357.

    Proteomic databases

    PRIDEi C0PZ54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACN47442 ; ACN47442 ; SPC_3357 .
    PATRICi 32365648. VBISalEnt12305_3417.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    OMAi DNRTGGY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci SENT476213:GH8J-3410-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
      Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
      PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RKS4594.

    Entry informationi

    Entry nameiIF2_SALPC
    AccessioniPrimary (citable) accession number: C0PZ54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3