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C0PZ54

- IF2_SALPC

UniProt

C0PZ54 - IF2_SALPC

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Protein
Translation initiation factor IF-2
Gene
infB, SPC_3357
Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi400 – 4078GTP By similarity
Nucleotide bindingi446 – 4505GTP By similarity
Nucleotide bindingi500 – 5034GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT476213:GH8J-3410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:SPC_3357
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001599: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Translation initiation factor IF-2UniRule annotation
PRO_1000118772Add
BLAST

Proteomic databases

PRIDEiC0PZ54.

Interactioni

Protein-protein interaction databases

STRINGi476213.SPC_3357.

Structurei

3D structure databases

ProteinModelPortaliC0PZ54.
SMRiC0PZ54. Positions 2-50.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini391 – 560170tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni400 – 4078G1 By similarity
Regioni425 – 4295G2 By similarity
Regioni446 – 4494G3 By similarity
Regioni500 – 5034G4 By similarity
Regioni536 – 5383G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0PZ54-1 [UniParc]FASTAAdd to Basket

« Hide

MTDVTLKALA AERQVSVDRL VQQFADAGIR KSADDSVSAQ EKQTLLAHLN    50
REAVSGPDKL TLQRKTRSTL NIPGTGGKSK SVQIEVRKKR TFVKRDPQEA 100
ERLAAEEQAQ REAEEQARRE AEEQAKREAQ QKAEREAAEQ AKREAAEKAK 150
REAAEKDKVS NQQTDDMTKT AQAEKARREN EAAELKRKAE EEARRKLEEE 200
ARRVAEEARR MAEENKWTAT PEPVEDTSDY HVTTSQHARQ AEDENDREVE 250
GGRGRGRNAK AARPAKKGKH AESKADREEA RAAVRGGKGG KRKGSSLQQG 300
FQKPAQAVNR DVVIGETITV GELANKMAVK GSQVIKAMMK LGAMATINQV 350
IDQETAQLVA EEMGHKVILR RENELEEAVM SDRDTGAAAE PRAPVVTIMG 400
HVDHGKTSLL DYIRSTKVAS GEAGGITQHI GAYHVETDNG MITFLDTPGH 450
AAFTSMRARG AQATDIVVLV VAADDGVMPQ TIEAIQHAKA AGVPVVVAVN 500
KIDKPEADPD RVKNELSQYG ILPEEWGGES QFVHVSAKAG TGIDELLDAI 550
LLQAEVLELK AVRKGMASGA VIESFLDKGR GPVATVLVRE GTLHKGDIVL 600
CGFEYGRVRA MRNELGQEVL EAGPSIPVEI LGLSGVPAAG DEVTVVRDEK 650
KAREVALYRQ GKFREVKLAR QQKSKLENMF ANMTEGEVHE VNIVLKADVQ 700
GSVEAISDSL LKLSTDEVKV KIIGSGVGGI TETDATLAAA SNAILVGFNV 750
RADASARKVI ESESLDLRYY SVIYNLIDEV KAAMSGMLSP ELKQQIIGLA 800
EVRDVFKSPK FGAIAGCMVT EGTIKRHNPI RVLRDNVVIY EGELESLRRF 850
KDDVNEVRNG MECGIGVKNY NDVRVGDMIE VFEIIEIQRT IA 892
Length:892
Mass (Da):97,402
Last modified:May 5, 2009 - v1
Checksum:i0D690F8E64505885
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN47442.1.
RefSeqiYP_002638883.1. NC_012125.1.

Genome annotation databases

EnsemblBacteriaiACN47442; ACN47442; SPC_3357.
PATRICi32365648. VBISalEnt12305_3417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN47442.1 .
RefSeqi YP_002638883.1. NC_012125.1.

3D structure databases

ProteinModelPortali C0PZ54.
SMRi C0PZ54. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 476213.SPC_3357.

Proteomic databases

PRIDEi C0PZ54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN47442 ; ACN47442 ; SPC_3357 .
PATRICi 32365648. VBISalEnt12305_3417.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
OMAi DNRTGGY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci SENT476213:GH8J-3410-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
    Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
    PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS4594.

Entry informationi

Entry nameiIF2_SALPC
AccessioniPrimary (citable) accession number: C0PZ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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