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C0PYP2 (EX7L_SALPC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exodeoxyribonuclease 7 large subunit

EC=3.1.11.6
Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit
Gene names
Name:xseA
Ordered Locus Names:SPC_1143
OrganismSalmonella paratyphi C (strain RKS4594) [Complete proteome] [HAMAP]
Taxonomic identifier476213 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378

Catalytic activity

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378

Subunit structure

Heterooligomer composed of large and small subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00378.

Sequence similarities

Belongs to the XseA family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionExonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

exodeoxyribonuclease VII complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionexodeoxyribonuclease VII activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378
PRO_1000200678

Sequences

Sequence LengthMass (Da)Tools
C0PYP2 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: F3EE08B9074B024F

FASTA44950,667
        10         20         30         40         50         60 
MLSSQTSSIF TVSRLNQTVR LLLEQEMGQV WISGEISNFT QPASGHWYFT LKDDTAQVRC 

        70         80         90        100        110        120 
AMFRNSNRRV TFRPQHGQQV LVRANITLYE PRGDYQIIAE SMQPAGEGLL QQKYEQLKAK 

       130        140        150        160        170        180 
LQAEGLFDQQ HKQPLPSPAH CVGVITSKTG AALHDILHVL KRRDPSLPVI IYPTAVQGDD 

       190        200        210        220        230        240 
APGQIVRAIE LANARGECDV LIVGRGGGSL EDLWSFNDER VARAIFASRI PVVSAVGHET 

       250        260        270        280        290        300 
DVTIADFVAD LRAPTPSAAA EIVSRNQQEL LRQIQSAQQR LGMAMDYYLA NRSRRFTQIF 

       310        320        330        340        350        360 
HRLQQQHPQL RLARQQTALE RLRQRMGFAL EARIKQANQR QQRVSQRLSQ QNPQPRIHRA 

       370        380        390        400        410        420 
QSRIQQLEYR LTENIRSRLS EQRERFGNAV THLEAVSPLA TLARGYTVST TTDGKVLKKI 

       430        440 
KQVKAGDIMT TRLEDGWLES EVKSVTPGT 

« Hide

References

[1]"Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RKS4594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000857 Genomic DNA. Translation: ACN45309.1.
RefSeqYP_002636750.1. NC_012125.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING476213.SPC_1143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACN45309; ACN45309; SPC_1143.
PATRIC32361106. VBISalEnt12305_1193.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1570.
HOGENOMHOG000229265.
OMARLECVIF.
OrthoDBEOG64R65J.

Enzyme and pathway databases

BioCycSENT476213:GH8J-1161-MONOMER.

Family and domain databases

HAMAPMF_00378. Exonuc_7_L.
InterProIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00237. xseA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEX7L_SALPC
AccessionPrimary (citable) accession number: C0PYP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families