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C0PYP2

- EX7L_SALPC

UniProt

C0PYP2 - EX7L_SALPC

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Protein

Exodeoxyribonuclease 7 large subunit

Gene
xseA, SPC_1143
Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciSENT476213:GH8J-1161-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunit (EC:3.1.11.6)
Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name:
Exonuclease VII large subunit
Gene namesi
Name:xseA
Ordered Locus Names:SPC_1143
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001599: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. exodeoxyribonuclease VII complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Exodeoxyribonuclease 7 large subunitUniRule annotationPRO_1000200678Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits By similarity.

Protein-protein interaction databases

STRINGi476213.SPC_1143.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.

Phylogenomic databases

eggNOGiCOG1570.
HOGENOMiHOG000229265.
OMAiRLECVIF.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

C0PYP2-1 [UniParc]FASTAAdd to Basket

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MLSSQTSSIF TVSRLNQTVR LLLEQEMGQV WISGEISNFT QPASGHWYFT    50
LKDDTAQVRC AMFRNSNRRV TFRPQHGQQV LVRANITLYE PRGDYQIIAE 100
SMQPAGEGLL QQKYEQLKAK LQAEGLFDQQ HKQPLPSPAH CVGVITSKTG 150
AALHDILHVL KRRDPSLPVI IYPTAVQGDD APGQIVRAIE LANARGECDV 200
LIVGRGGGSL EDLWSFNDER VARAIFASRI PVVSAVGHET DVTIADFVAD 250
LRAPTPSAAA EIVSRNQQEL LRQIQSAQQR LGMAMDYYLA NRSRRFTQIF 300
HRLQQQHPQL RLARQQTALE RLRQRMGFAL EARIKQANQR QQRVSQRLSQ 350
QNPQPRIHRA QSRIQQLEYR LTENIRSRLS EQRERFGNAV THLEAVSPLA 400
TLARGYTVST TTDGKVLKKI KQVKAGDIMT TRLEDGWLES EVKSVTPGT 449
Length:449
Mass (Da):50,667
Last modified:May 5, 2009 - v1
Checksum:iF3EE08B9074B024F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN45309.1.
RefSeqiYP_002636750.1. NC_012125.1.

Genome annotation databases

EnsemblBacteriaiACN45309; ACN45309; SPC_1143.
PATRICi32361106. VBISalEnt12305_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN45309.1 .
RefSeqi YP_002636750.1. NC_012125.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 476213.SPC_1143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN45309 ; ACN45309 ; SPC_1143 .
PATRICi 32361106. VBISalEnt12305_1193.

Phylogenomic databases

eggNOGi COG1570.
HOGENOMi HOG000229265.
OMAi RLECVIF.
OrthoDBi EOG64R65J.

Enzyme and pathway databases

BioCyci SENT476213:GH8J-1161-MONOMER.

Family and domain databases

HAMAPi MF_00378. Exonuc_7_L.
InterProi IPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view ]
Pfami PF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00237. xseA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
    Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
    PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS4594.

Entry informationi

Entry nameiEX7L_SALPC
AccessioniPrimary (citable) accession number: C0PYP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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