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C0PXG5

- FUCI_SALPC

UniProt

C0PXG5 - FUCI_SALPC

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Protein

L-fucose isomerase

Gene
fucI, SPC_3035
Organism
Salmonella paratyphi C (strain RKS4594)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei337 – 3371Proton acceptor By similarity
Metal bindingi337 – 3371Manganese By similarity
Active sitei361 – 3611Proton acceptor By similarity
Metal bindingi361 – 3611Manganese By similarity
Metal bindingi528 – 5281Manganese By similarity

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT476213:GH8J-3084-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomerase (EC:5.3.1.25)
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene namesi
Name:fucI
Ordered Locus Names:SPC_3035
OrganismiSalmonella paratyphi C (strain RKS4594)
Taxonomic identifieri476213 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001599: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591L-fucose isomeraseUniRule annotationPRO_1000165096Add
BLAST

Proteomic databases

PRIDEiC0PXG5.

Interactioni

Subunit structurei

Homohexamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi476213.SPC_3035.

Structurei

3D structure databases

ProteinModelPortaliC0PXG5.
SMRiC0PXG5. Positions 1-591.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
OMAiKEGQDYR.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

C0PXG5-1 [UniParc]FASTAAdd to Basket

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MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL ITEKIRHACG    50
AQVECVIADT CIAGMAESAA CEEKFSSQNV GVTITVTPCW CYGSETIDMD 100
PMRPKAIWGF NGTERPGAVY LAAALAAHSQ KGIPAFSIYG HDVQDADDTS 150
IPADVEEKLL RFARAGLAVA SMKGKSYLSV GGVSMGIAGS IVDHNFFESW 200
LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY GEDQNASQYK 250
RNEAQNRAVL KESLLMAMCI RDMMQGNKTL ADKGLVEESL GYNAIAAGFQ 300
GQRHWTDQYP NGDTAEALLN SSFDWNGVRE PFVVATENDS LNGVAMLFGH 350
QLTGTAQIFA DVRTYWSPEA VERVTGQALS GLAEHGIIHL INSGSAALDG 400
ACKQRDSEGK PTMKPHWEIS QQEADACLAA TEWCPAIHEY FRGGGYSSRF 450
LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS VELPKAMHDQ LDARTNSTWP 500
TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF ITLAAMLRIP 550
VCMHNVEEAK IYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R 591
Length:591
Mass (Da):64,771
Last modified:May 5, 2009 - v1
Checksum:i0A1C6439714D46AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN47123.1.
RefSeqiYP_002638564.1. NC_012125.1.

Genome annotation databases

EnsemblBacteriaiACN47123; ACN47123; SPC_3035.
PATRICi32365002. VBISalEnt12305_3100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000857 Genomic DNA. Translation: ACN47123.1 .
RefSeqi YP_002638564.1. NC_012125.1.

3D structure databases

ProteinModelPortali C0PXG5.
SMRi C0PXG5. Positions 1-591.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 476213.SPC_3035.

Proteomic databases

PRIDEi C0PXG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACN47123 ; ACN47123 ; SPC_3035 .
PATRICi 32365002. VBISalEnt12305_3100.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000249674.
OMAi KEGQDYR.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci SENT476213:GH8J-3084-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi."
    Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.
    PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKS4594.

Entry informationi

Entry nameiFUCI_SALPC
AccessioniPrimary (citable) accession number: C0PXG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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