C0PWW2 (GAL1_SALPC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactokinase
EC=2.7.1.6

Alternative name(s):
Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	SPC_0770

Organism

Salmonella paratyphi C (strain RKS4594) [Complete proteome] [HAMAP]

Taxonomic identifier

476213 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella enterica subsp. enterica serovar Paratyphi C

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) By similarity. HAMAP-Rule MF_00246
Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP-Rule MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP-Rule MF_00246
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00246.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Galactokinase HAMAP-Rule MF_00246		PRO_1000125382
Regions
	Nucleotide binding	124 – 130	7	ATP By similarity
	Region	34 – 37	4	Substrate binding By similarity
Sites
	Active site	174	1	Proton acceptor By similarity
	Metal binding	130	1	Magnesium By similarity
	Metal binding	162	1	Magnesium By similarity
	Binding site	223	1	Substrate By similarity
	Site	28	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0PWW2 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 1A91E742F26165BD	FASTA	382	41,317
	10 20 30 40 50 60 MNLKEKTRAL FAEIFSYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRN 70 80 90 100 110 120 DRTVRVIAAD YDNQVEEFSL DAPIVTHDSQ QWSNYVRGVV KHLQQRNNAF GGVDMVISGN 130 140 150 160 170 180 VPQGAGLSSS ASLEVAVGTV FQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL 190 200 210 220 230 240 GKKDHALLID CRTLGAKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP 250 260 270 280 290 300 ALRDVSLEAF NAVASELDPV VAKRVRHVLS ENARTVEAAS ALEKGDLQRM GQLMAESHAS 310 320 330 340 350 360 MRDDFEITVP QIDTLVDIVK ATIGDQGGVR MTGGGFGGCV VALIPEDLVP AVRQAVAQQY 370 380 EAKTGIKETF YVCKPSQGAG QC

References

[1]

"Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi." Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H., Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L. PLoS ONE 4:E4510-E4510(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RKS4594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000857 Genomic DNA. Translation: ACN44944.1.
RefSeq	YP_002636385.1. NC_012125.1.
3D structure databases
ProteinModelPortal	C0PWW2.
ModBase	Search...
Protein-protein interaction databases
STRING	476213.SPC_0770.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACN44944; ACN44944; SPC_0770.
GeneID	7553269.
KEGG	sei:SPC_0770.
PATRIC	32360370. VBISalEnt12305_0827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0153.
HOGENOM	HOG000241100.
KO	K00849.
OMA	MPCAINY.
ProtClustDB	PRK05101.
Enzyme and pathway databases
BioCyc	SENT476213:GH8J-787-MONOMER.
UniPathway	UPA00214.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
HAMAP	MF_00246. Galactokinase.
InterPro	IPR000705. Galactokinase. IPR022963. Galactokinase_bac. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal-bd. IPR013750. GHMP_kinase_C_dom. IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR006206. Mevalonate/galactokinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_SALPC

Accession

Primary (citable) accession number: C0PWW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program