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C0NXP6

- LIPA_AJECG

UniProt

C0NXP6 - LIPA_AJECG

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Protein
Lipoyl synthase, mitochondrial
Gene
HCBG_07690
Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi146 – 1461Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi152 – 1521Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi172 – 1721Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi176 – 1761Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi179 – 1791Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:HCBG_07690
OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri447093 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000001631: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion Reviewed prediction
Add
BLAST
Chaini38 – 430393Lipoyl synthase, mitochondrialUniRule annotation
PRO_0000398246Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC0NXP6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0NXP6-1 [UniParc]FASTAAdd to Basket

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MATSAGKLRT LYSAHSSLSS LPPSARPTLQ LATLRSYATT TPHDSPIGNT    50
SNTPPTVKRP ATAFKDKLNA GPAFSDFVSG KKDEPLDPAE AYALKTALVG 100
PPGRKKEITR LPPWLKTAIP DSSNYKRIKN DLRGLNLHTV CEEARCPNIA 150
DCWGGSSKSA ATATIMLMGD TCTRGCRFCS VKTSNKPPPL DPHEPDNTAE 200
ALSRWGLGYV VLTSVDRDDL ADGGARHFAE TVMKIKQKAP NILVECLTGD 250
YAGDLDMVAL VANSGLDVFA HNVETVEALT PFVRDRRASF QQSLRVLKAA 300
KAAKPELITK TSLMLGLGET EAQLWDALRA LRAINVDVVT FGQYMRPTKR 350
HMAVHEYVRP DVFDLWKERA LEMGFLYCAS GPLVRSSYKA GEAFIENVLK 400
KRRGENAGSV NEKVTTSENV KKLVAGEAMM 430
Length:430
Mass (Da):46,821
Last modified:May 5, 2009 - v1
Checksum:iC0C098FB51E28C50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG663376 Genomic DNA. Translation: EEH03564.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG663376 Genomic DNA. Translation: EEH03564.1 .

3D structure databases

ProteinModelPortali C0NXP6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

Entry informationi

Entry nameiLIPA_AJECG
AccessioniPrimary (citable) accession number: C0NXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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