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C0NX46 (CBPYA_AJECG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 124107 By similarity
PRO_0000407416
Chain125 – 544420Carboxypeptidase Y homolog A
PRO_0000407417

Sites

Active site2651 By similarity
Active site4561 By similarity
Active site5171 By similarity

Amino acid modifications

Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential
Disulfide bond178 ↔ 417 By similarity
Disulfide bond312 ↔ 326 By similarity
Disulfide bond336 ↔ 359 By similarity
Disulfide bond343 ↔ 352 By similarity
Disulfide bond381 ↔ 387 By similarity

Sequences

Sequence LengthMass (Da)Tools
C0NX46 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: B885B537E0B9C911

FASTA54460,584
        10         20         30         40         50         60 
MKSLALALLV GGAIASGPQQ QVLREPVDDP QAAETPLQKI SDIFGHLSEQ AGNVWEDVMD 

        70         80         90        100        110        120 
KFPDTLMDAI TQTPPPKKHN RRPDSQWDHI VRGSDVQAVW VEGDAGEKHR KVGGRLDTYD 

       130        140        150        160        170        180 
LRVKAVDPSN LGIDTVKQYS GYLDDNENDK HLFYWFFESR NDPKNDPVVL WLNGGPGCSS 

       190        200        210        220        230        240 
LTGLFLELGP SSITKQLKVK YNEFSWNSNA SVIFLDQPVN VGYSYSSSSV SNTQAAGKDV 

       250        260        270        280        290        300 
YALLTLFFEQ FPEYSQQDFH IAGESYAGHY IPVFASEIMS HSHRNINLKS ILVGNGLTDP 

       310        320        330        340        350        360 
LSQYPHYRPM ACGEGGYPAV LSSSSCQAMD NALPRCLAMI QACYNTESRW SCVPASIYCN 

       370        380        390        400        410        420 
NALIGPYQRS GMNPYDVRSK CEGGNLCYTQ LDDISKYLNQ DAVMESLGAE VSSYESCNMD 

       430        440        450        460        470        480 
INRNFLFQGD WMQPYMRVVP TLLTQMPVLI YAGDADFICN WLGNKAWTEA LEYPGHDEFA 

       490        500        510        520        530        540 
AAEMKNLTSL NHEDMKVIGQ VKSAGNFTFM RLFGGGHMVP MDQPEASLEF FNRWLGGEWS 


AKSP 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG663375 Genomic DNA. Translation: EEH03912.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_AJECG
AccessionPrimary (citable) accession number: C0NX46
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries