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C0NX46

- CBPYA_AJECG

UniProt

C0NX46 - CBPYA_AJECG

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei265 – 2651PROSITE-ProRule annotation
    Active sitei456 – 4561PROSITE-ProRule annotation
    Active sitei517 – 5171PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:HCBG_08038
    OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri447093 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000001631: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 124107By similarityPRO_0000407416Add
    BLAST
    Chaini125 – 544420Carboxypeptidase Y homolog APRO_0000407417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi178 ↔ 417By similarity
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi312 ↔ 326By similarity
    Disulfide bondi336 ↔ 359By similarity
    Disulfide bondi343 ↔ 352By similarity
    Disulfide bondi381 ↔ 387By similarity
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0NX46-1 [UniParc]FASTAAdd to Basket

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    MKSLALALLV GGAIASGPQQ QVLREPVDDP QAAETPLQKI SDIFGHLSEQ    50
    AGNVWEDVMD KFPDTLMDAI TQTPPPKKHN RRPDSQWDHI VRGSDVQAVW 100
    VEGDAGEKHR KVGGRLDTYD LRVKAVDPSN LGIDTVKQYS GYLDDNENDK 150
    HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFLELGP SSITKQLKVK 200
    YNEFSWNSNA SVIFLDQPVN VGYSYSSSSV SNTQAAGKDV YALLTLFFEQ 250
    FPEYSQQDFH IAGESYAGHY IPVFASEIMS HSHRNINLKS ILVGNGLTDP 300
    LSQYPHYRPM ACGEGGYPAV LSSSSCQAMD NALPRCLAMI QACYNTESRW 350
    SCVPASIYCN NALIGPYQRS GMNPYDVRSK CEGGNLCYTQ LDDISKYLNQ 400
    DAVMESLGAE VSSYESCNMD INRNFLFQGD WMQPYMRVVP TLLTQMPVLI 450
    YAGDADFICN WLGNKAWTEA LEYPGHDEFA AAEMKNLTSL NHEDMKVIGQ 500
    VKSAGNFTFM RLFGGGHMVP MDQPEASLEF FNRWLGGEWS AKSP 544
    Length:544
    Mass (Da):60,584
    Last modified:May 5, 2009 - v1
    Checksum:iB885B537E0B9C911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG663375 Genomic DNA. Translation: EEH03912.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG663375 Genomic DNA. Translation: EEH03912.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

    Entry informationi

    Entry nameiCBPYA_AJECG
    AccessioniPrimary (citable) accession number: C0NX46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3