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C0NX46

- CBPYA_AJECG

UniProt

C0NX46 - CBPYA_AJECG

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651PROSITE-ProRule annotation
Active sitei456 – 4561PROSITE-ProRule annotation
Active sitei517 – 5171PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:HCBG_08038
OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri447093 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000001631: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 124107By similarityPRO_0000407416Add
BLAST
Chaini125 – 544420Carboxypeptidase Y homolog APRO_0000407417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 417By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 326By similarity
Disulfide bondi336 ↔ 359By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi381 ↔ 387By similarity
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiC0NX46.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0NX46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLALALLV GGAIASGPQQ QVLREPVDDP QAAETPLQKI SDIFGHLSEQ
60 70 80 90 100
AGNVWEDVMD KFPDTLMDAI TQTPPPKKHN RRPDSQWDHI VRGSDVQAVW
110 120 130 140 150
VEGDAGEKHR KVGGRLDTYD LRVKAVDPSN LGIDTVKQYS GYLDDNENDK
160 170 180 190 200
HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFLELGP SSITKQLKVK
210 220 230 240 250
YNEFSWNSNA SVIFLDQPVN VGYSYSSSSV SNTQAAGKDV YALLTLFFEQ
260 270 280 290 300
FPEYSQQDFH IAGESYAGHY IPVFASEIMS HSHRNINLKS ILVGNGLTDP
310 320 330 340 350
LSQYPHYRPM ACGEGGYPAV LSSSSCQAMD NALPRCLAMI QACYNTESRW
360 370 380 390 400
SCVPASIYCN NALIGPYQRS GMNPYDVRSK CEGGNLCYTQ LDDISKYLNQ
410 420 430 440 450
DAVMESLGAE VSSYESCNMD INRNFLFQGD WMQPYMRVVP TLLTQMPVLI
460 470 480 490 500
YAGDADFICN WLGNKAWTEA LEYPGHDEFA AAEMKNLTSL NHEDMKVIGQ
510 520 530 540
VKSAGNFTFM RLFGGGHMVP MDQPEASLEF FNRWLGGEWS AKSP
Length:544
Mass (Da):60,584
Last modified:May 5, 2009 - v1
Checksum:iB885B537E0B9C911
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG663375 Genomic DNA. Translation: EEH03912.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG663375 Genomic DNA. Translation: EEH03912.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi C0NX46.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

Entry informationi

Entry nameiCBPYA_AJECG
AccessioniPrimary (citable) accession number: C0NX46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3