C0NUQ8 (DAPB_AJECG) Reviewed, UniProtKB/Swiss-Prot
Last modified
June 13, 2012.
Version 20.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable dipeptidyl-aminopeptidase B Short name=DPAP B EC=3.4.14.5 | ||||
| Gene names |
| ||||
| Organism | Ajellomyces capsulata (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum) [Reference proteome] | ||||
| Taxonomic identifier | 447093 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces ›  |
Protein attributes
| Sequence length | 923 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity. |
| Catalytic activity | Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. |
| Subcellular location | Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity. |
| Sequence similarities | Belongs to the peptidase S9B family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane Vacuole |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Aminopeptidase Hydrolase Protease Serine protease |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 923 | 923 | Probable dipeptidyl-aminopeptidase B | PRO_0000412124 | |||||
Regions | |||||||||
| Topological domain | 1 – 99 | 99 | Cytoplasmic Potential | ||||||
| Transmembrane | 100 – 120 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
| Topological domain | 121 – 923 | 803 | Vacuolar Potential | ||||||
| Compositional bias | 64 – 83 | 20 | Asp-rich | ||||||
Sites | |||||||||
| Active site | 756 | 1 | Charge relay system By similarity | ||||||
| Active site | 833 | 1 | Charge relay system By similarity | ||||||
| Active site | 866 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 135 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 351 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 574 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 815 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 902 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome sequence of Ajellomyces capsulatus strain G186AR." Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.  Birren B.W.Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | GG663372 Genomic DNA. Translation: EEH04721.1. |
3D structure databases | |
| ProteinModelPortal | C0NUQ8. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S09.006. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| OrthoDB | EOG4Q885J. |
Family and domain databases | |
| InterPro | IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view] |
| Pfam | PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view] |
| PROSITE | PS00708. PRO_ENDOPEP_SER. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DAPB_AJECG | ||||||||
| Accession | Primary (citable) accession number: C0NUQ8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |