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C0NUQ8

- DAPB_AJECG

UniProt

C0NUQ8 - DAPB_AJECG

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei756 – 7561Charge relay systemBy similarity
    Active sitei833 – 8331Charge relay systemBy similarity
    Active sitei866 – 8661Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:HCBG_06672
    OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri447093 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000001631: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 923923Probable dipeptidyl-aminopeptidase BPRO_0000412124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi815 – 8151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi902 – 9021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC0NUQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9999CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini121 – 923803VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei100 – 12021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 8320Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0NUQ8-1 [UniParc]FASTAAdd to Basket

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    MATEKGHGRD DEERVPLTRG STEFRNSIDS FDYSSSTASL SLAVIDRINN    50
    STQDAALGEK GPRDDDDDRY WDDDVEYDVE DADYIPSGGK PMHKSVKIAL 100
    WTLLFLSLGG WSLAFVLFIF RSHDTYETPI SSEDNISSGG LRGDRITLDD 150
    VLGEEWMPRH HFISWFPGPN GEDGLLLEKD GPGSTGYLRV EDIVSRKDTK 200
    SSKGSIVLMR KNTFTVGGET VICSQVWPSP DLKTVLVLSE KKQNWRHSFT 250
    GKYWLFDVDT QTGQPLDPAA QDQRIQLASW SPQSDAVVFT RDNNMFLRKL 300
    SSKEVTTITS DGGVDLFYGV PDWVYEEEVF SGNSATWWAH DGNYIAFLRT 350
    NESAVPEYPL QYFVSRPSGE DPNLGEENYP EVREIKYPKA GAPNPIVDLQ 400
    FYDVRKGEIF SVDVADRFPD DNRLIIEVLW ASNGKVLVRE TNRESDILII 450
    AAINVLSRTG KIVRKEDINA LDGGWVEPTQ STRFIPADPS NGRPEDGYID 500
    TVIHEGRDQL AYFTPLDNPE PLILTKGPSE VVNSPSGVDL KRGLVYFVVA 550
    GNEPWERHVY SVKFDGTALQ PVTNVSESSY YDVSFSDGAG YALLNFQGPK 600
    VPWQKVISTP ANENPFEEII EQNNHLSRKL RLFSLESKVF QYINIDGFSL 650
    PVLERRPPNF DPTKKYPVLF YLYGGPGSQT VDKKFRVDFQ SYVASTLGYI 700
    VVTVDGRGTG YIGRKSLSIV RGKLGHYEAR DQIEVAKKWA AKPYVDESRM 750
    AIWGWSYGGF MTLKTIEEDG GRTFQYGMAV APVTDWRYYD SIYAERYMHT 800
    PQHNPQGYDS SAISNTTALA NNVRFLVMHG TADDNVHIQN TLTLLDKLDL 850
    ANVDNYDVHV FPDSDHNINF HNAHKIVYTR LADWLVNAFN GQWLKTNNPT 900
    PNDSLFRRAA TWAGLSYNFK HLH 923
    Length:923
    Mass (Da):104,146
    Last modified:May 5, 2009 - v1
    Checksum:i5C27FFBC9F38335B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG663372 Genomic DNA. Translation: EEH04721.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG663372 Genomic DNA. Translation: EEH04721.1 .

    3D structure databases

    ProteinModelPortali C0NUQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

    Entry informationi

    Entry nameiDAPB_AJECG
    AccessioniPrimary (citable) accession number: C0NUQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3