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Protein

Mitochondrial glycine transporter

Gene

HCBG_04074

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:HCBG_04074Imported
OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)Imported
Taxonomic identifieri447093 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
Proteomesi
  • UP000001631 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC0NMU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 101SolcarPROSITE-ProRule annotationAdd BLAST85
Repeati128 – 212SolcarPROSITE-ProRule annotationAdd BLAST85
Repeati244 – 328SolcarPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

InParanoidiC0NMU7
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

C0NMU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGSTNGAR LKISTSSKPK FHFVAGLASG LSSAILLQPA DLLKTRIQQA
60 70 80 90 100
HQTSALLFTI RKILASPQPI RGLWRGTLPS ALRTGFGSAL YFSSLNALRQ
110 120 130 140 150
CVANQGPLVP LHGDRDDKRT RTSALPKLSH TANLLTGAMA RTAAGFIMMP
160 170 180 190 200
VTVIKVRYES DYYAYRSIWG AGRDIVRSEG FRGLFSGFGA TAIRDAPYAG
210 220 230 240 250
LYVVFYEQSK KNLNALNFGG LTTARPLSDE PACKDNSEKQ LVTSSISVNF
260 270 280 290 300
VSGALAAGLA TSITNPFDVV KTRLQLMPNK YRNMAHAVRL MLREDGVRSL
310 320 330 340
FGGLGLRMGR KAISSALAWT VYEELILKAE KRWPDQDNIE QLAP
Length:344
Mass (Da):37,483
Last modified:May 5, 2009 - v1
Checksum:i020E10F8E04AE643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG663367 Genomic DNA Translation: EEH07195.1

Genome annotation databases

EnsemblFungiiEEH07195; EEH07195; HCBG_04074

Similar proteinsi

Entry informationi

Entry nameiC0NMU7_AJECG
AccessioniPrimary (citable) accession number: C0NMU7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 25, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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